Development of electrochemistry-based biosensors in medical field

Year 2025, Volume: 5 Issue: 2, 71 - 74, 31.12.2025

Ergin Taşkın , Hülya Öztürk Doğan

https://izlik.org/JA45SU26ZC

Abstract

Electrochemistry, as a subdivision of chemistry, describes the kind of physical chemistry where one studies the reactions occurring chemically and expresses these as electrical processes, playing an important role in the diagnosis and therapeutic procedures of diseases in the health field, particularly modern medicine. This art of science stands equally important in diagnosis and treatment, while developing biosensors at a preliminary stage, with glucose biosensors developed first and, in later stages, have seen applications for widespread use in assessing biomarkers for cholesterol and cancer, and are still in use to date. Therefore, with the developments in nanotechnology in this century, the development and AI integration of electrochemistry-based biosensors have marginally placed and strongly act as a bright hope in diagnosis and treatment. Biosensors stand as big players regarding monitoring diseases in medicine while offering early diagnosis and therapeutic approaches, like controlled drug release, that need more precision and specificity. More than this, this process allows the construction of less heavy and highly portable personal health monitoring systems. The present work aims to analyze the development of electrochemistry in health, its current situation, and developments with promise for the future.

Keywords

Electrochemistry , Biosensor , Nanotechnology

References

• 1. Theyagarajan K, Kim YJ. Recent Developments in the Design and Fabrication of Electrochemical Biosensors Using Functional Materials and Molecules. Biosensors. 2023;13(4):424. doi:10.3390/bios13040424
• 2. Rackus DG, Shamsi MH, Wheeler AR. Electrochemistry, biosensors and microfluidics: a convergence of fields. Chem Soc Rev. 2015;44(15):5320-5340. doi:10.1039/C4CS00369A
• 3. Bard AJ, Murray RW. Electrochemistry - Introduction. In: Proceedings of the National Academy of Sciences of the United States of America. Vol 109. Natl Acad Sciences 2101 Constitution Ave NW, Washington, DC 20418 USA; 2012:11484-11486.
• 4. Cui H, Xin X, Su J, Song S. Research Progress of Electrochemical Biosensors for Diseases Detection in China: A Review. Biosensors. 2025;15(4):231. doi:10.3390/bios15040231
• 5. Clark L, Lyons C. Electrode systems for continuous monitoring in cardiovascular surgery. Ann NY Acad Sci. 1962;102:29-45.
• 6. Shoaib A, Darraj A, Khan ME, et al. A Nanotechnology-Based Approach to Biosensor Application in Current Diabetes Management Practices. Nanomaterials. 2023;13(5):867. doi:10.3390/nano13050867
• 7. Justino CIL, Freitas AC, Pereira R, Duarte AC, Rocha Santos TAP. Recent developments in recognition elements for chemical sensors and biosensors. TrAC Trends Anal Chem. 2015;68(5):2-17. doi:10.1016/j.trac.2015.03.006
• 8. Majdinasab M, Mitsubayashi K, Marty JL. Optical and Electrochemical Sensors and Biosensors for the Detection of Quinolones. Trends Biotechnol. 2019;37(8):898-915. doi:10.1016/j.tibtech.2019.01.004
• 9. Bordbar MM, Sheini A, Hashemi P, Hajian A, Bagheri H. Disposable Paper-Based Biosensors for the Point-of-Care Detection of Hazardous Contaminations—A Review. Biosensors. 2021;11(9):316. doi:10.3390/bios11090316
• 10. Ronkainen NJ, Halsall HB, Heineman WR. Electrochemical biosensors. Chem Soc Rev. 2010;39(5):1747. doi:10.1039/b714449k
• 11. Perumal V, Hashim U. Advances in biosensors: Principle, architecture and applications. J Appl Biomed. 2014;12(1):1-15. doi:10.1016/j.jab.2013.02.001
• 12. Kilic NM, Singh S, Keles G, Cinti S, Kurbanoglu S, Odaci D. Novel Approaches to Enzyme-Based Electrochemical Nanobiosensors. Biosensors. 2023;13(6):622. doi:10.3390/bios13060622
• 13. Lee JE, Pack SP. Recent Progress in DNA Biosensors: Target-Specific and Structure-Guided Signal Amplification. Biosensors. 2025;15(8):476. doi:10.3390/bios15080476
• 14. Bastos-Soares EA, Sousa RMO, Gómez AF, et al. Single domain antibodies in the development of immunosensors for diagnostics. Int J Biol Macromol. 2020;165:2244-2252. doi:10.1016/j.ijbiomac.2020.10.031
• 15. Wang W, He Y, He S, et al. A Brief Review of Aptamer-Based Biosensors in Recent Years. Biosensors. 2025;15(2):120. doi:10.3390/bios15020120
• 16. Bagotsky VS. Elektrokimyanın Temelleri. 2nd ed. (Tapan NA, Aksu ML, eds.). Nobel Akademik Yayıncılık; 2015. 17. Kissinger PT, Bott AW. Electrochemistry for the non-electrochemist. Curr Sep. 2002;20(2):51-54.
• 18. Keskin M, Arslan F. Biyosensörler. Gazi Üniversitesi Fen Fakültesi Derg. 2020;1(1-2):51-60.
• 19. Özbek Z. Kolesterol Tayini için Biyosensör Geliştirilmesi. Afyon Kocatepe Üniversitesi Uluslararası Mühendislik Teknol ve Uygulamalı Bilim Derg. 2023;6(1):63-74. doi:10.53448/akuumubd.1296685
• 20. Watson CJ, Ledwidge MT, Phelan D, et al. Proteomic Analysis of Coronary Sinus Serum Reveals Leucine-Rich α2-Glycoprotein as a Novel Biomarker of Ventricular Dysfunction and Heart Failure. Circ Hear Fail. 2011;4(2):188-197. doi:10.1161/CIRCHEARTFAILURE.110.952200
• 21. Maurer M, Burri S, de Marchi S, et al. Plasma homocysteine and cardiovascular risk in heart failure with and without cardiorenal syndrome. Int J Cardiol. 2010;141(1):32-38. doi:10.1016/j.ijcard.2008.11.131
• 22. Turgut B. Biosensors and Healthcare. J Acad Soc Resour. 2023;8(47):2492-2498. doi:10.29228/ASRJOURNAL.68930
• 23. Cunha DR, Segundo MA, Quinaz MB. Electrochemical methods for evaluation of therapeutic monoclonal antibodies: A review. Biosens Bioelectron. 2025;271:116988. doi:10.1016/j.bios.2024.116988
• 24. Özçelik E, Erdal M, Özsoy Erginer Y. Recent Technologies in Controlled Release Drug Delivery. J Adv Res Heal Sci. 2022;5(2):122-129. doi:10.26650/JARHS2022-1122852
• 25. Sunal KS. Amperometrik ve İmpedimetrik Biyosensörler Ile Farklı Tip Kanserlerin Biyobelirteci Olan CD-105 (Endoglin) Tayini. Erciyes University; 2021.
• 26. Özoğlu Ö, Ünal MA, Altuntaş EG. Biosensors: Lactate Biosensors in Food and Health Field. Turkish J Life Sci. 2017;2(2):180-193.
• 27. Eabd Alrida S, Obed O, Taha E, Abdullah T, Hathal M, Somogyi V. Applications of artificial intelligence in nanotechnology. Eng Technol J. 2024;42(9):1193-1209. doi:10.30684/etj.2024.148957.1736
• 28. Chugh V, Basu A, Kaushik A, Manshu, Bhansali S, Basu AK. Employing nano-enabled artificial intelligence (AI)-based smart technologies for prediction, screening, and detection of cancer. Nanoscale. 2024;16(11):5458-5486. doi:10.1039/D3NR05648A