Dark Urine in Pediatric Emergency Service

Year 2026, Volume: 7 Issue: 1, 34 - 37, 24.02.2026

Halime Yazar , Resul Yılmaz , Esra Kilim

https://doi.org/10.56766/ntms.1699907

https://izlik.org/JA48RR92NY

Abstract

Urine color varies depending on food, drugs and other compounds. Metronidazole is an antimicrobial, antiprotozoal agent widely used in the treatment of various infections and urine darkening is a rare side effect. When administered in toxic doses, side effects can occur in many systems. In this case report, dark urine that appeared after ingestion of unknown amount of metronidazole due to suicide in a patient who applied to the emergency department is mentioned. It was observed that the color of urine improved spontaneously upon discontinuation of the drug, and it should be kept in mind that cautions should be taken in terms of other side effects of the drug.

Keywords

dark urine , drug intoxication , metronidazole

References

• 1. Aycock RD, Kass DA. Abnormal urine color. South Med J. 2012;105(1):43-47.
• 2. Wald R. Urinalysis in the diagnosis of kidney disease. Curhan GC, editor. UpToDate; 2025 28 August. Available from: https://www.uptodate.com/contents/urinalysis-in-the-diagnosis-of-kidney-disease?search=Urinalysis%20in%20the%20diagnosis%20of%20kidney%20disease&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1.
• 3. Yılmaz R, Özçetin M, Karaarslan E, Esmeray H. Erken Tespit Edilen Alkaptonüri: Vaka Sunusu. Çocuk Dergisi 2011;11(2):78-80.
• 4. Kapoor K, Chandra M, Nag D, Paliwal JK, Gupta RC, Saxena RC. Evaluation of metronidazole toxicity: a prospective study. Int J Clin Pharmacol Res 1999;19(3):83-88.
• 5. Johnson M. Metronidazole: An overview. Hoope DC, editor. UptoDate; 2025 28 August. [Jan 08, 2025.]. Available from: https://www.uptodate.com/contents/metronidazole-an-overview?search=Metronidazole%3A%20An%20overview.%20&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1.
• 6. Revollo JY, Lowder JC, Pierce AS, Twilla JD. Urine discoloration associated with metronidazole: a rare occurrence. J Pharm Technol. 2014;30(2):54-56.
• 7. Bruce TA. Dark Urine Related to Metronidazole Therapy. JAMA. 1971;218(12):1832.
• 8. Geeting GK, Roberts JR. Urine discoloration secondary to metronidazole. Am J Emerg Med. 2001;19(4):322.
• 9. Lamp KC, Freeman CD, Klutman NE, Lacy MK. Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials. Clin Pharmacokinet. 1999;36(5):353-73.