Effect of Cornus Mas L. Extract on Organs in Rats Given Nicotine

Abstract

Nicotine plays an important role in oxidative stress formation. For this purpose, to reveal the antioxidant effect of cornelian cherry plant, the effects of nicotine-induced oxidative stress. 28 adult Wistar Albino (180-220 g) male rats were used in the study. Rats were divided into four groups as control group (n = 6), cornelian cherry group (n = 7), nicotine group (n = 7) and nicotine + cornelian cherry group (n = 8). While nicotine extract was applied to the experimental group, cornelian cherry extract was applied to the treatment group as well as nicotine. TBARS, SOD, GSH, GSSG, TOS, TAS, Redox potential values were measured by spectrophotometric analysis in lung, brain, kidney, heart and liver tissues. OSI and GSH / GSSG values were calculated as TOS / TAS and GSH / GSSG rates, respectively. When the experimental groups are examined, it is seen that there is a significant difference between the nicotine-treated group and the other groups (p <0.05). Its effect on lung, brain, kidney, heart and liver tissues is seen biochemically. Especially when the TAS value is examined, a significant difference is observed in the Nicotine group compared to other groups (p <0.05). Cornelian cherry is understood to be an important plant with antioxidant properties against nicotine by increasing TAS level against oxidative stress formation.

Keywords

• Oxidative stress,Cornus mas L,Nicotine,Cornelian cherry

References

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