DEVELOPMENT OF A HYBRID MODEL TO QUANTIFY THE SINGLE AND DOUBLE STRAND BREAKS FOLLOWING THE IRON 57 DE-EXCITATION

Year 2017, , 143 - 152, 30.06.2017

H. Oudira D: Lotfi A. Safi

https://doi.org/10.17261/Pressacademia.2017.583

Abstract

The
therapeutic utility of certain Auger emitters such as iodine-125 depends on
their position within the cell nucleus. Or diagnostically, and to maintain as
low as possible cell damage, it is preferable to have radionuclide localized
outside the cell or at least the core. One solution to this problem is to
consider markers capable of conveying anticancer drugs to the tumor site
regardless of their location within the human body. The objective of this study
is to simulate the impact of a complex such as bleomycin on single and double
strand breaks in the DNA molecule. Indeed, this simulation consists of the
following transactions: Construction of BLM -Fe- DNA complex, simulation of the
electron’s transport from the metastable state excitation of Fe 57 by the Monte
Carlo method, treatment of chemical reactions in the considered environment by
the diffusion equation. For physical, physico-chemical and finally chemical
steps, the geometry of the complex is considered as a sphere of 50 nm centered
on the binding site , and the mathematical method used is called  step by step based on Monte Carlo codes. 

Keywords

hybrid model

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