SOLVOTHERMAL SYNTHESIS AND BIOLOGICAL ACTIVITY OF NI-DOPED ZINC OXIDE NANOPARTICLES

Year 2017, , 240 - 246, 30.06.2017

Samima Shahid Muhammad Mudassar Sher

https://doi.org/10.17261/Pressacademia.2017.595

Abstract

Metal oxide nanoparticles are
potential candidate for making future antimicrobials. Increased interest is due
to change in fundamental properties at nanoscale. Ni-doped zinc oxide nano-particles
were prepared for pharmacological studies. Co-precipitation and solvo-thermal
methods were employed which yielded Ni-doped zinc oxide nano-particles and
un-doped zinc oxide nano-particles were synthesized via solvo-thermal method.
All prepared nano-particles were characterized using X-ray diffraction studies
whereas doping was confirmed by Energy Dispersive X-ray analysis. Shape and
morphology of these nano-particles was assessed using Scanning Electron
Microscopy. The synthesized nano-particles have shown antibacterial activity
against both Gram-negative and Gram-positive bacteria designating these
nano-particles as future broad spectrum antibacterial. The optical properties
were also studied by measuring the energy band gap and were found 1.50 eV for un-doped zinc oxide
nano-particles, and it decreases to 1.47 eV
for Ni-doped zinc oxide. Ni-doped zinc oxide nanoparticles were proved to be
active future pharmaceutical and biomedical agents. 

Keywords

Antibacterials, morphology, nanoparticles, energy dispersive X-ray, doping

References

• Al-Harbi, T. (2011). Hydrothermal synthesis and optical properties of Ni doped ZnO hexagonal nanodiscs. J. Alloy. Compd. 509(2), 387-390.
• Ananda, S. (2014). Synthesis and Characterization of Se-doped ZnO Nanoparticles by Electrochemical Method: Photodegradation Kinetics of Indigo Carmine Dye and Study of Antimicrobial, Antimitotic Activities of Se-doped ZnO Nanoparticles. J. Am. Chem. Sci. 4(5), 616-637.
• Buzea, C., Pacheco, I. I., & Robbie, K. (2007). Nanomaterials and nanoparticles: sources and toxicity. Biointerphases, 2(4), MR17-MR71.
• Cai, A. J., Wang, Y. L., Xing, S. T., Du, L. Q., & Ma, Z. C. (2013). Tuned morphologies of DNA-assisted ZnO struggling against pH. Ceram. Int. 39(1), 605-609.
• Hewakuruppu, Y. L., Dombrovsky, L. A., Chen, C., Timchenko, V., Jiang, X., Baek, S., & Taylor, R. A. (2013). Plasmonic “pump–probe” method to study semi-transparent nanofluids. Appl. Opt., 52(24), 6041-6050.
• Hua, G., Zhang, Y., Ye, C., Wang, M., & Zhang, L. (2007). Controllable growth of ZnO nanoarrays in aqueous solution and their optical properties.Nanotechnology, 18(14), 145605.
• Hsu, H. C., Cheng, H. M., Wu, C. Y., Huang, H. S., Lee, Y. C., & Hsieh, W. F. (2006). Luminescence of selective area growth of epitaxial ZnO nanowires and random-growth-oriented nanobelts. Nanotechnology, 17(5), 1404.
• Khatoon, S., & Ahmad, T. (2012). Synthesis, optical and magnetic properties of Ni-doped ZnO nanoparticles. J. Mat. Sci. Engine. B, 2(6), 325-333.
• Leven, M., Berghe, D. A. V., Mertens, F., Vlietinck, A., & Lammens, E. (1979). Screening of higher plants for biological activities I. Antimicrobial activity. Planta Medica, 36(08), 311-321.
• Liewhiran, C., Seraphin, S., & Phanichphant, S. (2006). Synthesis of nano-sized ZnO powders by thermal decomposition of zinc acetate using Broussonetia papyrifera (L.) Vent pulp as a dispersant. Curr. Appl. Phy. 6(3), 499-502.
• Moriga, T., Y. Hayashi, Y,. Kondo, K., Nishimura, Y. (2004). Zinc oxide, tin oxide-based transparent conductive thin film of amorphous, J. Vac. Sci. and Technol A, 22, 705–1710.
• Raja, K., Ramesh, P. S., & Geetha, D. (2014). Synthesis, structural and optical properties of ZnO and Ni-doped ZnO hexagonal nanorods by Co-precipitation method. Spectrochimica Acta Part A. 120, 19-24.
• Sahoo, S. K., Parveen, S., & Panda, J. J. (2007). Clinical nanomedicine.The present and future of nanotechnology in human health care. Nanomed. Nanotechnol. Biol. Med. 3(1), 20-31.
• Siegel, R. W. (1994). What do we really know about the atomic-scale structures of nanophase materials?. J. Phy. Chem. Solids, 55(10), 1097-1106.
• Wang, Z. L. (2004). Zinc oxide nanostructures: growth, properties and applications. J. Physics: Condensed Matter, 16(25), R829.
• Xu, M., Fujita, D., Kajiwara, S., Minowa, T., Li, X., Takemura, T., ... & Hanagata, N. (2010). Contribution of physicochemical characteristics of nano-oxides to cytotoxicity. Biomaterials, 31(31), 8022-8031.
• Yan, H., Johnson, J., Law, M., He, R., Knutsen, K., McKinney, J. R., ... & Yang, P. (2003). ZnO nanoribbon microcavity lasers. Adv. Mat. 15(22), 1907-1911.
• Zhang, J., Wang, S., Xu, M., Wang, Y., Zhu, B., Zhang, S., ... & Wu, S. (2009). Hierarchically porous ZnO architectures for gas sensor application. Crys. Gro. Degn., 9(8), 3532-3537. Zhong, Q., & Matijević, E. (1996). Preparation of uniform zinc oxide colloids by controlled double-jet precipitation. J. Mat. Chem. 6(3), 443447.