Elucidating Ionization Behavior: Potentiometric Titration for Precise Determination of pKa Values in Medicinal Chemistry

Year 2024, Volume: 4 Issue: 2, 46 - 50, 23.04.2024

Safiye Nihal Aydoğdu , Durişehvar Ünal

Abstract

The determination of pKa values holds paramount importance in the field of medicinal chemistry, serving as a critical parameter for understanding the ionization behavior of pharmaceutical compounds. This study employs potentiometric titration as a precise method to elucidate the pKa values of diverse molecules. The experimental methodology involved a carefully controlled titration setup, utilizing a pH meter to monitor the titration curve and identify inflection points corresponding to the dissociation of acidic or basic functional groups.

Keywords

pKa values, potentiometric titration, medicinal chemistry, pharmacokinetics, drug discovery.

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