Effects Of Magnesium Oxide Treatment On Serum Electrolyte Levels In Constipated Children

Abstract

Background: Magnesium oxide (MgO) is a standard treatment for functional constipation. However, this medication has not been evaluated extensively for possible alterations of plasma magnesium (Mg) levels and other electrolytes. This retrospective study aimed to appraise the effects of serum magnesium with some other electrolyte levels after oral MgO treatment in children with functional constipation. Methodology: After the approval of the local ethical committee, archives of the patients who had been admitted to two different Pediatric Surgery outpatient clinics in different cities between 2014-2018 were evaluated. The demographic findings of the patients were recorded. For the diagnosis of chronic constipation, Rome-III classification criteria were used. After complete physical examinations, if there were no possible organic reasons other than chronic dietary problems, serum electrolyte levels were obtained and evaluated. Findings were evaluated statistically and discussed with the literature. Result: The magnesium value was significantly higher in the constipation group (p<0.05) compared to the control group. In generalized linear models (GLM) results, the effects of calcium, potassium, and sodium levels on serum magnesium levels were significant (p<0.05). The effect of calcium and potassium levels on serum magnesium was statistically significant in the constipation group (p<0.05). In the control group, only the effect of chlorine level on serum magnesium was statistically significant (p<0.05). Conclusion: MgO is a valuable treatment for constipation. However, especially by taking into account the dose adjustment, close follow-up of the patients for side effects is necessary to prevent patients from electrolyte imbalance.

Keywords

• Constipation
• magnesium
• magnesium oxide
• electrolyte

Kabızlıklı Çocuklarda Magnezyum Oksit Tedavisinin Serum Elektrolit Düzeyleri Üzerine Etkileri

Abstract

Giriş: Magnezyum oksit (MgO) fonksiyonel kabızlık için standart bir tedavidir. Ancak bu ilaç, plazma magnezyum (Mg) düzeyleri ve diğer elektrolitlerdeki olası değişiklikler açısından kapsamlı bir şekilde değerlendirilmemiştir. Bu retrospektif çalışma, fonksiyonel kabızlığı olan çocuklarda oral MgO tedavisi sonrası serum magnezyumunun diğer bazı elektrolit düzeyleriyle birlikte etkilerini değerlendirmeyi amaçladı. Yöntem: Yerel etik kurul onayı alındıktan sonra 2014-2018 yılları arasında farklı şehirlerdeki iki farklı Çocuk Cerrahisi polikliniğine başvuran hastaların arşivleri değerlendirildi. Hastaların demografik bulguları kaydedildi. Kronik kabızlığın tanısı için Roma-III sınıflandırma kriterleri kullanıldı. Tam fizik muayene sonrasında kronik beslenme sorunları dışında olası organik nedenler yoksa serum elektrolit düzeyleri elde edilerek değerlendirildi. Bulgular istatistiksel olarak değerlendirildi ve literatürle tartışıldı. Sonuç: Konstipasyon grubunda magnezyum değeri kontrol grubuna göre anlamlı derecede yüksekti (p<0,05). Genelleştirilmiş doğrusal model (GLM) sonuçlarında kalsiyum, potasyum ve sodyum düzeylerinin serum magnezyum düzeylerine etkisi anlamlıydı (p<0,05). Kabızlık grubunda kalsiyum ve potasyum düzeylerinin serum magnezyumu üzerindeki etkisi istatistiksel olarak anlamlıydı (p<0.05). Kontrol grubunda ise sadece klor düzeyinin serum magnezyumu üzerindeki etkisi istatistiksel olarak anlamlıydı (p<0.05). Sonuç: MgO kabızlık için değerli bir tedavi yöntemidir. Ancak özellikle doz ayarlaması dikkate alınarak hastaların elektrolit dengesizliğinin önlenmesi için yan etkiler açısından yakın takip edilmesi gerekmektedir.

Keywords

• Kabızlık
• magnezyum
• magnezyum oksit
• elektrolit

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