Investi̇Gation of Serum Vitamin D Levels in Term Newborns and Their Mothers

Abstract

Vitamin D has effects on a large number of organs and systems, starting from the intrauterine period. Its severe deficiency during the neonatal and childhood period leads to a disease called the Rickets. Therefore, in this report we review the topic of Vitamin D deficiency among pregnant women and neonates, which we believe represents a significant public health issue. Material and Method: In this study, we prospectively investigated healthy mothers, who gave birth vaginally or by cesarean section during the 37th to 42nd weeks of gestation and their term babies at the Duzce University Medical Faculty Hospital. We investigated the correlation between the serum vitamin D levels of the mother and the baby and the baby’s percentiles, and the reflections of this deficiency on the babies from the mothers with vitamin D deficiency. Results: Serum vitamin D levels of 45 mothers and 45 babies were investigated. The mean vitamin D level was 13.4 ng/mL among the participating mothers, among babies was 8.6 ng/mL. There was a statistically significant correlation between the vitamin D levels of the mothers and babies. Conclusion: If applicable, D vitamin level should be investigated in mothers prior to planning of pregnancy and treatment initiated in case of deficiency; if this is not applicable, vitamin D level should be evaluated as a routine control parameter during pregnancy. We believe that timely diagnosis and treatment of vitamin D deficiency of the mother could prevent potential vitamin D deficiency in the baby.

Keywords

• D vitamini,, gebelik,, kord kanı yenidoğan

References

1. References 1- Cantorna MT. Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease. Progress in biophysics and molecular biology. 2006;92(1):60-4. 2- Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics. 2008;122(2):398-417. 3- Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM. Maternal vitamin D deficiency increases the risk of preeclampsia. The Journal of Clinical Endocrinology & Metabolism. 2007;92(9):3517-22. 4- Brunvand L, Quigstad E, Urdal P, Haug E. Vitamin D deficiency and fetal growth. Early human development. 1996;45(1):27-33. 5- Féron F, Burne THJ, Brown J, Smith E, McGrath JJ, Mackay-Sim A, et al. Developmental Vitamin D 3 deficiency alters the adult rat brain. Brain research bulletin. 2005;65(2):141-8. 6- Hollis BW, Wagner CL. Vitamin D requirements during lactation: high-dose maternal supplementation as therapy to prevent hypovitaminosis D for both the mother and the nursing infant. The American journal of clinical nutrition. 2004;80(6):1752S-8S. 7- Wagner CL, Greer FR. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008;122(5):1142-52. 8- Hatun Ş, Bereket A, Çalıkoğlu AS, Özkan B. Günümüzde D vitamini yetersizliği ve nutrisyonel rikets. Çocuk Sağlığı ve Hastalıkları Dergisi. 2003;46:224-41. 9- Specker BL, Valanis B, Hertzberg V, Edwards N, Tsang RC. Sunshine exposure and serum 25-hydroxyvitamin D concentrations in exclusively breast-fed infants. The Journal of pediatrics. 1985;107(3):372-6. 10- Bebeklerde D Vitamini Yetersizliğinin Önlenmesi Ve Kemik Sağlığının Korunması Projesi Ankara: T.C. Sağlık bakanlığı Ana Çocuk Sağlığı ve Aile Planlaması Genel Müdürlüğü; 2015 [updated 29.04.2015; cited 2015 03.09.2015]. Available from: www.mersinsaglik.gov.tr/Download%5C83_8_d%20vit%20genelgesi.doc. 11- Gebelere D Vitamini Destek Programi Rehberi Ankara: T.C. Sağlık Bakanlığı; 2011 [updated 25.04.2011; cited 2015 03.09.2015]. Available from: http://www.saglik.gov.tr/TR/belge/1-12659/gebelere-d-vitamini-destek- programi-rehberi.html. 12- Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30. 13- Mannion CA, Gray-Donald K, Koski KG. Association of low intake of milk and vitamin D during pregnancy with decreased birth weight. Canadian Medical Association Journal. 2006;174(9):1273-7. 14- Bowyer L, Catling‐Paull C, Diamond T, Homer C, Davis G, Craig ME. Vitamin D, PTH and calcium levels in pregnant women and their neonates. Clinical endocrinology. 2009;70(3):372-7.