Immunodeficiency In The Human Newborn

Year 2019, Volume: 7 Issue: Ek - IRUPEC 2019 Kongresi Tam Metin Bildirileri, 14 - 18, 10.12.2019

Öner Özdemir

Abstract

Abstract
The normal neonate’s immune system is anatomically intact, antigenically naive, and shows somewhat decreased role of a number of immunological pathways. Aside from anatomic characteristics (eg, thin skin and mucosal barriers) of newborn, weakened proinflammatory and T helper cell type 1 (Th1) cytokine release and lessened cell-mediated immunity predispose the neonate more susceptible to all types of infections. However, most of the newborn stand this period without sickness due to intact innate immunity with other adaptive defense mechanisms, and maternally transferred immunoglobulin G (IgG).
Besides unique immunity of the premature baby and normal newborn; risk factors, clinical features and laboratory evaluation of primary immunodeficiency diseases (PIDs) are told in this presentation. Moreover, most important PIDs of the newborn including antibody deficiencies, cellular/combined immunodeficiencies, phagocytic diseases, complemento-pathies and innate immune system disorders are briefly mentioned here as well.

Keywords

Immunodeficiency

References

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