Treatment Of Gastroesophageal Reflux In Children With Lipid-Laden Macrophage
Yıl 2019,
Cilt: 7 Sayı: Ek - IRUPEC 2019 Kongresi Tam Metin Bildirileri, 621 - 625, 10.12.2019
Oğuz Eğil
,
Memduha Akçay
,
Pembe Oltulu
,
Sevgi Pekcan
Öz
In chronic cough, one of the etiologies is microaspirations due to gastroesophageal reflux diseases. “Lipid-laden macrophage” (LLM) the definition of lipid-containing macrophage after staining with Sudan 4 or Oil Red O. It is considered as a sign of gastroesophageal reflux in recurrent pneumonia.
Materials and Methods
In this study, we retrospectively evaluated the children undergoing bronchoscopy between 2016 and 2019 in our center. Patients’ medical records have been retrospectively analyzed and their parents were called for further information
Kaynakça
- Referances
1) Berquist WE, Rachelefsky GS, Kadden M, Siegel SC, Katz RM, Fonkalsrud EW et al. Gastroesophageal reflux-associated recurrent pneumonia and chronic asthma in children. Pediatrics. 1981 Jul;68(1):29-35.
2) Corwin RW, Irwin RS. The lipid-laden alveolar macrophage as a marker of aspiration in parenchymal lung disease. Am Rev Respir Dis. 1985 Sep;132(3):576-81.
3) Colombo JL, Hallberg TK. Recurrent aspiration in children: lipid-laden alveolar macrophage quantitation. Pediatr Pulmonol. 1987 Mar-Apr;3(2):86-9.
4) Bauer ML, Lyrene RK. Chronic aspiration in children: evaluation of the lipid-laden macrophage index. Pediatr Pulmonol. 1999 Aug;28(2):94-100.
5) Knauer-Fischer S, Ratjen F. Lipid-laden macrophages in bronchoalveolar lavage fluid as a marker for pulmonary aspiration. Pediatr Pulmonol. 1999 Jun;27(6):419-22.
6) Özdemir P, Erdinç M, Vardar R, et al. The role of microaspiration in the pathogenesis of gastroesophageal reflux-related chronic cough. J Neurogastroenterol Motil. 2017;23:41–48.
7) de Benedictis FM, Bush A. Respiratory manifestations of gastro-oesophageal reflux in children. Arch Dis Child. 2018 Mar;103(3):292-296. doi: 10.1136/archdischild-2017-312890. Epub 2017 Sep 7.
8) Villamil M, Casas C, Restrepo SM, Caceres J, Ramirez O, Ovalle NV. Experience of Lipid Laden Macrophage Index in Bronchoalveolar Lavage in Children at a Fourth Level Children's Hospital. Am J Respir Crit Care Med 2019;199:A1885.
9) Adams R, Ruffin R, Campbell D. The value of the lipid-laden macrophage index in the assessment of aspiration pneumonia. Aust N Z J Med 1997;27:550-553
10) Rosen R, Fritz J, Nurko A, Simon D, Nurko S. Lipid-laden macrophage index is not an indicator of gastroesophageal reflux-related respiratory disease in children. Pediatrics. 2008 Apr;121(4):e879-84. doi: 10.1542/peds.2007-0723. Epub 2008 Mar 24.
Yıl 2019,
Cilt: 7 Sayı: Ek - IRUPEC 2019 Kongresi Tam Metin Bildirileri, 621 - 625, 10.12.2019
Oğuz Eğil
,
Memduha Akçay
,
Pembe Oltulu
,
Sevgi Pekcan
Kaynakça
- Referances
1) Berquist WE, Rachelefsky GS, Kadden M, Siegel SC, Katz RM, Fonkalsrud EW et al. Gastroesophageal reflux-associated recurrent pneumonia and chronic asthma in children. Pediatrics. 1981 Jul;68(1):29-35.
2) Corwin RW, Irwin RS. The lipid-laden alveolar macrophage as a marker of aspiration in parenchymal lung disease. Am Rev Respir Dis. 1985 Sep;132(3):576-81.
3) Colombo JL, Hallberg TK. Recurrent aspiration in children: lipid-laden alveolar macrophage quantitation. Pediatr Pulmonol. 1987 Mar-Apr;3(2):86-9.
4) Bauer ML, Lyrene RK. Chronic aspiration in children: evaluation of the lipid-laden macrophage index. Pediatr Pulmonol. 1999 Aug;28(2):94-100.
5) Knauer-Fischer S, Ratjen F. Lipid-laden macrophages in bronchoalveolar lavage fluid as a marker for pulmonary aspiration. Pediatr Pulmonol. 1999 Jun;27(6):419-22.
6) Özdemir P, Erdinç M, Vardar R, et al. The role of microaspiration in the pathogenesis of gastroesophageal reflux-related chronic cough. J Neurogastroenterol Motil. 2017;23:41–48.
7) de Benedictis FM, Bush A. Respiratory manifestations of gastro-oesophageal reflux in children. Arch Dis Child. 2018 Mar;103(3):292-296. doi: 10.1136/archdischild-2017-312890. Epub 2017 Sep 7.
8) Villamil M, Casas C, Restrepo SM, Caceres J, Ramirez O, Ovalle NV. Experience of Lipid Laden Macrophage Index in Bronchoalveolar Lavage in Children at a Fourth Level Children's Hospital. Am J Respir Crit Care Med 2019;199:A1885.
9) Adams R, Ruffin R, Campbell D. The value of the lipid-laden macrophage index in the assessment of aspiration pneumonia. Aust N Z J Med 1997;27:550-553
10) Rosen R, Fritz J, Nurko A, Simon D, Nurko S. Lipid-laden macrophage index is not an indicator of gastroesophageal reflux-related respiratory disease in children. Pediatrics. 2008 Apr;121(4):e879-84. doi: 10.1542/peds.2007-0723. Epub 2008 Mar 24.