Ultrasonographic Measurement of the Thyroid Isthmus Thickness in Healthy Turkish Infants, Children, and Adolescents

Year 2021, Volume: 9 Issue: 3, 126 - 129, 31.12.2021

Edis Çolak , Behzat Özkan , Burak Polat , Sinan Genç

https://doi.org/10.21765/pprjournal.1008354

Abstract

Aim: The importance of establishing reference ranges for thyroid volume is a worldwide trend, however, to date, limited data are available regarding thyroid isthmus thickness (TIT) in healthy children. The present study aimed to report the reference values for TIT in children aged between 0 and 18 years from Turkey.

Material and Method: The TIT was measured by ultrasonography in 447 subjects between December 2018 and September 2020. The 3rd, 10th, 25th, 50th, 75th, and 95th percentiles of the TIT according to age and gender were determined and compared with published data. The TIT values were compared with children’s age, gender, and Z-score data for weight, height, and body mass index (BMI).

Results: The median [interquartile range (IQR) 25 - 75] values for TIT were 1.5 (1.3-2.0) mm. The TI was thicker in females than in males and this gender difference was statistically significant (1.6mm vs. 1.5mm, p=0.023, respectively). The TIT was highly significantly associated with age, and Z-scores for weight, height, and BMI (r=0.461, r=0.457, r=0.448, and r=0.434, respectively; p<0.0001 for all). Z-score for weight was the strongest predictor of the TIT in the multivariate regression model.

Conclusion: This study is the first to report the normative data for TIT in healthy Turkish infants, children, and adolescents. The present results will provide valuable scientific input for developing reference standards for TIT on a national and international level.

Keywords

Thyroid isthmus, thyroid isthmus thickness, ultrasound

Sağlıklı Türk İnfant, Çocukluk ve Adolesan Yaş Grubunda Tiroid İstmus Kalınlığının Ultrasonografik Ölçümü

Abstract

Amaç: Tiroid bez hacmi için referans aralıklarının oluşturulması dünya çapında bir trend olmasına rağmen bugüne kadar sağlıklı çocuklarda tiroid istmus kalınlığı (TİK) ile ilgili sınırlı veri mevcuttur. Bu çalışmanın amacı 0-18 yaş arası Türk çocuklarda TİK'nın referans değerlerini belirlemektir.

Gereç ve Yöntem: Aralık 2018 - Eylül 2020 tarihleri arasında 447 kişide TİK ultrasonografi ile ölçüldü. TİK için 3., 10., 25., 50., 75. ve 95. persentil değerleri yaş ve cinsiyete göre hesaplandı ve yayınlanan verilerle karşılaştırıldı. TİK değerleri, çocukların yaş, cinsiyet ve ağırlık, boy, vücut kitle indeksi (VKİ) Z-skorları ile karşılaştırıldı.

Bulgular: TİK medyan [çeyrekler arası aralık (IQR) 25 - 75] değerleri 1.5 (1.3-2.0) mm idi. Tiroid istmus kadınlarda erkeklere göre daha kalındı ve bu cinsiyet farkı istatistiksel açıdan anlamlıydı (sırasıyla 1.6mm, 1.5mm ve p=0.023). TİK ve yaş, ağırlık, boy, VKİ Z-skor değerleri arasında belirgin fark gözlendi (sırasıyla r=0.461, r=0.457, r=0.448 ve r=0.434; p<0.0001). Ağırlık Z-skoru, çok değişkenli regresyon modelinde, TİK'nın en güçlü belirleyicisiydi.

Sonuç: Bu çalışma, sağlıklı Türk infant, çocukluk ve adolesan yaş grubunda TİK'nın normatif verileri bildiren ilk çalışmadır. Mevcut sonuçlar, ulusal ve uluslararası düzeyde TİK referans standartlarının geliştirilmesi için önemli bilimsel katkı sağlayacaktır.

Keywords

Tiroid istmus, tiroid istmus kalınlığı, ultrason

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