The Relationship Between Newly Derived Inflammatory Biomarkers from Hemogram and Serum Vitamin D Concentration in Pediatric Intensive Care Patients

Yıl 2024, Cilt: 12 Sayı: 1, 14 - 19, 31.03.2024

Resul Yılmaz , Javidan Maqsudov , Fikret Akyürek , Sinem Çimen Mehmet Talha Bayram

https://doi.org/10.21765/pprjournal.1444137

Öz

Introduction: Besides classical disorders of bone metabolism, vitamin D may explain the pathogenesis of many diseases associated with inflammation and vitamin D deficiency. While numerous studies support vitamin D's relationship with inflammation, some studies do not confirm this relationship. Novel Hemogram-Derived Inflammatory Biomarkers are new and inexpensive markers of inflammation that can be tested in all centers. The aim of this study is to investigate the relationship between 25-hydroxyvitamin D (25(OH)D) and new inflammatory markers and inflammation.

Material and methods: This study was conducted prospectively and data from 77 patients treated in the Pediatric Intensive Care Unit were included. Simultaneous 25(OH)D3, calcium, phosphorus and complete blood count results were recorded. Novel hemogram-derived inflammatory biomarkers, systemic inflammatory response index (SIRI) and systemic immune inflammatory index (SII), were calculated.

Results: There was no significant difference in hemogram-derived new inflammatory biomarkers between groups with and without vitamin D deficiency (p>0.05 for all).
Conclusions: Our study did not reveal a statistical association between these inexpensive and universally available biomarkers and vitamin D levels and inflammation. The validity of the findings should be confirmed with a larger number of subjects.

Anahtar Kelimeler

systemic inflammatory index, systemic inflammatory response index, vitamin D, pediatric intensive care

Çocuk Yoğun Bakım Hastalarında Serum D Vitamini Konsantrasyonu ile Hemogramdan Türetilmiş Yeni İnflamatuar Biyobelirteçler Arasındaki İlişki

Öz

Giriş: Klasik kemik metabolizması bozukluklarının yanı sıra D vitamini, inflamasyon ve D vitamini eksikliği ile ilişkili birçok hastalığın patogenezini açıklayabilir. Çok sayıda araştırma D vitamininin iltihaplanma ile ilişkisini desteklerken, bazı araştırmalar bu ilişkiyi doğrulamamaktadır. Hemogramdan Türetilmiş Yeni İnflamatuar Biyobelirteçler, tüm merkezlerde çalışılabilecek yeni ve ucuz inflamasyon belirteçleridir. Bu çalışmanın amacı, 25-hidroksi D vitamini (25(OH)D) ile yeni inflamatuar belirteçler ile inflamasyon arasındaki ilişkiyi araştırmaktır.

Gereç ve yöntemler: Bu çalışma prospektif olarak yürütüldü ve Çocuk Yoğun bakım Ünitesinde tedavi gören 77 hastanın verileri dahil edildi. Eş zamanlı çalışılan 25(OH)D3, kalsiyum, fosfor ve tam kan sayımı sonuçları kaydedildi. Hemogramdan türetilmiş yeni inflamatuar biyobelirteçler, sistemik inflamatuar yanıt indeksi (SIRI) ve sistemik immün inflamatuar indeks (SII) hesaplandı.

Bulgular: D vitamini eksikliği olan ve olmayan gruplar arasında hemogramdan türetilmiş yeni inflamatuar biyobelirteçler açısından anlamlı fark bulunmadı (tümü için p>0,05).
Sonuçlar: Çalışmamız, bu ucuz ve evrensel olarak bulunabilen biyobelirteçler ile D vitamini düzeyleri ve inflamasyon arasında istatistiksel bir ilişki varlığını ortaya koymamıştır. Daha fazla sayıda denek ile bulguların geçerliği doğrulanmalıdır.

Anahtar Kelimeler

sistemik inflamatuar indeks, sistemik inflamatuar yanıt indeksi, D vitamini, çocuk yoğun bakım

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