Intervertebral disc degeneration, inflammation, and bioactive lipids

Abstract

Intervertebral disc degeneration, inflammation, and bioactive lipids Intervertebral disc degeneration Intervertebral disc (IVD) degeneration is a common condition that is associated with significant morbidity. There is no specific treatment available for IVD except for surgical intervention. IVD is an inflammatory condition. I propose that IVD can be prevented and managed by local administration of lipoxin A4 (LXA4), a potent anti-inflammatory, cytoprotective and anti-osteoporotic metabolite formed from arachidonic acid (AA). Keywords: intervertebral disc, degeneration, lipoxin A4, arachidonic acid, inflammation.

Keywords

• intervertebral disc
• degeneration
• lipoxin A4
• arachidonic acid
• inflammation

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