Is there a relationship between Diffusion Weighted Imaging and Histopathological Type in Brain Metastases Due to Breast Cancer?

Abstract

Aim: The aim of this study is to evaluate the relationship between diffusion-weighted imaging (DWI) properties and apparent diffusion coefficient (ADC) values of metastases with the histological type of breast cancer in patients with breast cancer-related brain metastasis. Material and Methods: Between May 2008 - April 2011, 57 female patients who had been previously diagnosed with breast cancer in the radiology clinic were included in the study. Cases with invasive ductal carcinoma were considered group 1 (46 patients, 89 lesions) and cases with invasive lobular, comedo carcinoma and papillary cribriform carcinoma were considered group 2 ( 11 patients, 25 lesions). ADC values in both groups were compared by statistical analysis methods. Results: In group 1; 37 lesions (41.57%) and in group 2; 13 lesions (52%) included cystic component. In the group of invasive ductal carcinoma 48 lesions (53.92%) and 18 lesions (72%) of second group included peritumoral edema. The mean ADC value of the solid component of metastases (group1: 1.105x10-3mm2/ s, group2: 1.099x10-3mm2/ s) was higher than the average ADC value of normal brain parenchyma (group1: 0.790x10-3mm2/s, group2: 0.801x10-3mm2/s), and was statistically significant (p<0.001). In the comparison between the groups, no statistically significant difference was found between the mean ADC values of the solid components of metastases (p= 0.931). Conclusion: In our study, mean ADC values in brain metastases due to breast cancer were significantly higher than normal brain parenchyma. However, no statistically significant difference was found in the comparison of ADC values of the groups formed according to histopathological subtypes.

Keywords

• Breast Carcinoma
• diffusion-weighted imaging
• apparent diffusion coefficient

Meme Kanserine Bağlı Beyin Metastazlarında Difüzyon Ağırlıklı Görüntüleme ile Histopatolojik Tip Arasında Bir İlişki Var mı?

Abstract

Amaç: Bu çalışmanın amacı, meme kanserine bağlı beyin metastazı olan hastalarda meme kanserinin histolojik tipi ile metastazların difüzyon ağırlıklı görüntüleme (DAG) özellikleri ve görünür difüzyon katsayısı değerleri (ADC) arasındaki ilişkiyi değerlendirmektir. Gereç ve Yöntemler: Mayıs 2008-Nisan 2011 tarihleri arasında daha önce radyoloji kliniğinde meme kanseri tanısı almış 57 kadın hasta çalışmaya dahil edildi. İnvaziv duktal karsinomlu olgular grup 1 (46 hasta, 89 lezyon) ve invaziv lobüler, komedo karsinom ve papiller kribriform karsinomlu olgular grup 2 (11 hasta, 25 lezyon) olarak değerlendirildi. Her iki gruptaki ADC değerleri istatistiksel analiz yöntemleri ile karşılaştırıldı. Bulgular: Birinci grupta; 37 lezyon (%41,57) ve grup 2'de; 13 lezyon (%52) kistik komponent içeriyordu. İnvaziv duktal karsinom grubunda 48 lezyon (%53,92), ikinci grupta 18 lezyon (%72) peritümöral ödem içeriyordu. Solid metastazlarda ortalama ADC değeri (grup 1: 1,105x10-3mm2/s, grup2: 1,099 x10-3mm2/s normal beyin parankiminin ortalama ADC değerinden (grup 1: 0,790 x10-3mm2/s, grup2: 0,801 x10-3mm2/s) yüksekti ve fark istatistiksel olarak anlamlıydı (p<0.001). Gruplar arası karşılaştırmada solid metastazların ortalama ADC değerleri arasında istatistiksel olarak anlamlı fark bulunmadı (p=0,931). Sonuç: Çalışmamızda meme kanserine bağlı beyin metastazlarında ortalama ADC değerleri normal beyin parankimine göre anlamlı olarak yüksek bulundu. Ancak histopatolojik alt tiplere göre oluşturulan grupların ADC değerleri karşılaştırıldığında istatistiksel olarak anlamlı fark bulunmadı.

Keywords

• Meme Kanseri
• Difüzyon Ağırlıklı Görüntüleme
• Görünür Difüzyon Katsayısı

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