Yıl 2020, Cilt 3 , Sayı S1, Sayfalar 53 - 62 2020-05-15

COVID-19 ve Koagülopati
COVID-19 and Coagulopathy

Ayşegül ÜNÜVAR [1]


Ağır Akut Solunum Sendromu Coronavirus 2’nin (SARS-CoV2) etken patojen olduğu SARS-CoV2 enfeksiyonu (COVID-19) yeni bir enfeksiyon hastalığıdır. Akciğerler COVID-19 için hedef organdır; akut akciğer hasarı solunum yetmezliğine ilerleyebilir ve çoklu organ yetersizliği de gelişebilir. COVID-19; inflamasyon artışı, trombosit aktivasyonu, endotel disfonksiyonu ve kan akımında stazın etkisiyle hem venöz hem de arteriyel sistemde tromboz gelişimine neden olabilir. Bu derleme, COVID-19 pandemisinin ilk aylarındaki mevcut güncel bilgiler ışığı altında hazırlandı. Ancak, trombotik komplikasyonla ilgili çalışmalar da dahil mevcut kanıtlar çok sınırlıdır, başlıca az sayıda hastaların olduğu retrospektif analizlere dayalıdır, daha güçlü ve yüksek kalitede yeni çalışmalara ihtiyaç vardır.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is the causative pathogen of a new infectious disease, COVID-19. The lungs are the target organ for COVID-19; acute lung injury can progress to respiratory failure, and multiorgan failure can also occur. COVID-19 may predispose to both venous and arterial thromboembolic disease due to coagulation activation caused by a combination of excessive inflammation, platelet activation, endothelial dysfunction, and stasis in blood flow. This review was prepared in the light of the current information available in the first months of the COVID-19 pandemic. However, the existing evidence, including studies on thrombotic complications, is very limited and derived primarily from small and retrospective analyses, and more strong and high quality new studies are required.
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Birincil Dil tr
Konular Diş Hekimliği, Eczacılık, Farmakoloji ve Eczacılık, Toksikoloji, Temel Bilimler, Tıp
Bölüm Derleme
Yazarlar

Orcid: 0000-0002-4730-7697
Yazar: Ayşegül ÜNÜVAR (Sorumlu Yazar)
Kurum: İSTANBUL ÜNİVERSİTESİ
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 15 Mayıs 2020

APA ÜNÜVAR, A . (2020). COVID-19 ve Koagülopati. Sağlık Bilimlerinde İleri Araştırmalar Dergisi , 3 (S1) , 53-62 . Retrieved from https://dergipark.org.tr/tr/pub/sabiad/issue/54344/738110