Serotonin Syndrome After Alcohol and Methamphetamine Ingestion in a Patient on Escitalopram: Case Presentation

Year 2025, Volume: 1 Issue: 2, 100 - 102, 01.09.2025

Zeynep Saral Öztürk , Handan Özen Olcay , Yunsur Çevik

Abstract

Background: Serotonin syndrome is a rare but potentially life-threatening condition characterized by excessive serotonergic activity. This report describes a case of SS in a patient undergoing long-term escitalopram therapy who developed symptoms following the ingestion of methamphetamine and alcohol.
Case Presentation: A 42-year-old male on escitalopram presented with agitation, confusion, myoclonic movements, and a localized rash after methamphetamine and alcohol ingestion. Vital signs showed mild hypertension, low-grade fever, and hypoxemia; labs and ECG were normal. He improved rapidly with fluids, diazepam, and paracetamol, and was discharged after observation.
Conclusion: Clinical presentation included agitation, spontaneous clonus, and an unusual bullous skin lesion. Prompt supportive treatment led to symptom resolution, and the patient was discharged within six hours. This case underscores the importance of clinical vigilance for SS, particularly in patients with concurrent substance use and stable antidepressant therapy.

Keywords

serotonin syndrome , escitalopram , alcohol , methamphetamine

Ethical Statement

The patient informed consent form was obtained

Supporting Institution

There is no financial support of any person or institution in this research

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