Araştırma Makalesi
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The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats

Yıl 2020, Cilt: 24 Sayı: 2, 312 - 323, 01.04.2020
https://doi.org/10.16984/saufenbilder.638725

Öz

Cisplatin, an anticancer drug used in chemotherapy, has made considerable progress recently; particularly in the treatment of testicular cancer. However, the side effects of this treatment, limit its use. Grape Seed and Skin Extract (GSSE) and Ulva rigida (U. rigida) marine seaweeds are giving compounds with high antioxidant capacity. This work aims to develop a model in vivo to evaluate the protective effect of extracts of GSSE or U. rigida against the oxidative stress induced by cisplatin. This stress occurring in healthy cells is one of the major causes of the adverse effects of chemotherapy. Healthy male rats received an intraperitoneal injection of cisplatin only or cisplatin and GSSE or U. rigida extract. At the end of the treatment, the rats were sacrificed and from the crushed testicles; the supernatant was recovered for biochemical assays. The data showed that the dose of cisplatin induces testicular toxicity, and a pro-oxidant state characterized by increased levels of malondialdehyde, carbonyl proteins, superoxide anion, calcium and iron. Besides, treatment with cisplatin increases the activity of superoxide dismutase and inhibits the activity of catalase. GSSE or U. rigida extract exerts a protective effect on the testes of cisplatin-treated rats, or they protect against the adverse effects of oxidative stress induced by cisplatin to restore levels near control. This study demonstrated that GSSE and U. rigida can protect against cisplatin-induced cytotoxicity.

Destekleyen Kurum

Higher Institute of Medical Technologies, University of Tunis El Manar

Kaynakça

  • Sonia Hamlaoui
  • Sana mezghani
Yıl 2020, Cilt: 24 Sayı: 2, 312 - 323, 01.04.2020
https://doi.org/10.16984/saufenbilder.638725

Öz

Kaynakça

  • Sonia Hamlaoui
  • Sana mezghani
Toplam 2 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji
Bölüm Araştırma Makalesi
Yazarlar

Rihab Ksouri 0000-0002-6241-2989

Souha Rabah Bu kişi benim 0000-0002-6241-2989

Sana Mezghani 0000-0002-6241-2989

Sonia Hamlaoui 0000-0002-6241-2989

Yayımlanma Tarihi 1 Nisan 2020
Gönderilme Tarihi 27 Ekim 2019
Kabul Tarihi 7 Ocak 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 24 Sayı: 2

Kaynak Göster

APA Ksouri, R., Rabah, S., Mezghani, S., Hamlaoui, S. (2020). The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats. Sakarya University Journal of Science, 24(2), 312-323. https://doi.org/10.16984/saufenbilder.638725
AMA Ksouri R, Rabah S, Mezghani S, Hamlaoui S. The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats. SAUJS. Nisan 2020;24(2):312-323. doi:10.16984/saufenbilder.638725
Chicago Ksouri, Rihab, Souha Rabah, Sana Mezghani, ve Sonia Hamlaoui. “The Protective Effect of Grape Seed and Skin Extract and Ulva Rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats”. Sakarya University Journal of Science 24, sy. 2 (Nisan 2020): 312-23. https://doi.org/10.16984/saufenbilder.638725.
EndNote Ksouri R, Rabah S, Mezghani S, Hamlaoui S (01 Nisan 2020) The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats. Sakarya University Journal of Science 24 2 312–323.
IEEE R. Ksouri, S. Rabah, S. Mezghani, ve S. Hamlaoui, “The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats”, SAUJS, c. 24, sy. 2, ss. 312–323, 2020, doi: 10.16984/saufenbilder.638725.
ISNAD Ksouri, Rihab vd. “The Protective Effect of Grape Seed and Skin Extract and Ulva Rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats”. Sakarya University Journal of Science 24/2 (Nisan 2020), 312-323. https://doi.org/10.16984/saufenbilder.638725.
JAMA Ksouri R, Rabah S, Mezghani S, Hamlaoui S. The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats. SAUJS. 2020;24:312–323.
MLA Ksouri, Rihab vd. “The Protective Effect of Grape Seed and Skin Extract and Ulva Rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats”. Sakarya University Journal of Science, c. 24, sy. 2, 2020, ss. 312-23, doi:10.16984/saufenbilder.638725.
Vancouver Ksouri R, Rabah S, Mezghani S, Hamlaoui S. The Protective Effect of Grape Seed and Skin Extract and Ulva rigida Against Oxidative Stress Induced by Cisplatin on The Testis of Rats. SAUJS. 2020;24(2):312-23.

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