Yıl 2023,
Cilt: 27 Sayı: 2, 428 - 441, 30.04.2023
Cemil Örgev
,
Pınar Nazire Tanattı
,
Hülya Demirel
,
İsmail Ayhan Şengil
Destekleyen Kurum
Destekleyen kurum bulunmamaktadır.
Proje Numarası
Projeden veriler üeretilmemiştir.
Kaynakça
- [1] W. E. Elshorbagy, H. Abu-Qadais, M. K. Elsheamy, “Simulation of THM species in water distribution systems” Water Research, vol:34, issue 13, pp. 3431- 3439, 2000.
- [2] V. Uyak, K. Ozdemir, I. Toroz, “Multiple linear regression modeling of disinfection by-products formation in Istanbul drinking water reservoirs” Science of Total Environmental, vol: 378, pp. 269–280, 2007.
- [3] J. Zhang, J. Liu, C. S. He, C, Qian, Y. M, “Formation of iodo-trihalomethanes (I-THMs) during disinfection with chlorine or chloramine: Impact of UV/H2O2 pre-oxidation” Science of Total Environmental, pp. 640–641, 2018.
- [4] G. Hua, S. Yeats, “Control of trihalomethanes in wastewater treatment” Fla. Water Resource Journal, vol: 4, pp. 6-12, 2010.
- [5] A. Marcoux, G. Pelletier, C. Legay, C. Bouchard, M. J. Rodriguez, “Behavior of nonregulated disinfection by-products in water following multiple chlorination points during treatment” Science of Total Environmental, vol: 586, pp. 870–878, 2017.
- [6] A. M. Tugulea, R. Aranda-Rodriguez, D. Bérubé, M. Giddings, F. Lemieux, J. Hnatiw, F. Breton, “The influence of precursors and treatment process on the formation of Iodo-THMs in Canadian drinking water” Water Research, vol: 130, pp. 215-223, 2018.
- [7] T. Priya, P. Prakash, B. K. Mishra, “Understanding the coagulant activity of zirconium oxychloride to control THMs formation using response surface methodology” Ecotoxicology and Environmental Safety, vol:159, pp. 28-37, 2018.
- [8] E. M. Rodríguez, M. V. Gordillo, A. Rey, F. J. Beltrán, “Impact of TiO2/UVA photocatalysis on THM formation potential” Catalysis Today, vol: 313, pp.167-174, 2018.
- [9] S. K. Golfinopoulos, G. B. Arhonditsis, “Multiple regression models: a methodology for evaluating trihalomethane concentrations in drinking water from raw water characteristics” Chemosphere, vol: 47(9), pp.1007-1018, 2002.
- [10] V. Uyak, I. Toroz, S. Meric, “Monitoring and modeling of trihalomethanes (THMs) for a water treatment plant in Istanbul” Desalination, vol: 176(1-3), pp.91-101, 2005.
- [11] S. W. Krasner, M. J. McGuire, J. G. Jacangelo, N. L. Patania, K. M. Regan, A. E. Marco, “Occurrence of disinfection by-products in US drinking water” Journal Water Works Association, vol: 81, 8, pp. 41–53, 2001.
- [12] United States Environmental Protection Agency (USEPA). Guidelines for carcinogen risk assessment. Risk Assessment Forum. Washington DC. NCEA-F-0644 (Revised draft), 1999.
- [13] T. Priya, B. K. Mishra, “Enzyme mediated chloroform biotransformation and quantitative cancer risk analysis of trihalomethanes exposure in South East Asia” Exposure and Health, vol:9, 1, pp.61-75. 2017.
- [14] V. Uyak, “Multi-pathway risk assessment of trihalomethanes exposure in Istanbul drinking water supplies” Environmental International, vol: 32, 1, pp.12-21, 2006.
- [15] S. C. Lee, H. Guo, S. M. J. Lam, S. L. A. Lau, “Multipathway risk assessment on disinfection by-products of drinking water in Hong Kong” Environmental Research, vol: 94, 1, pp. 47-56, 2004.
- [16] A. Siddique, S. Saied, M. Mumtaz, M. M. Hussain, H. A. Khwaja, “Multipathways human health risk assessment of trihalomethane exposure through drinking water” Ecotoxicology, and Environmental Safety, vol: 116, pp. 129-136, 2015.
- [17] S. E. Hrudey, L. C. Backer, A. R. Humpage, S. W. Krasner, D. S. Michaud, L. E. Moore, B. D. Stanford, “Evaluating evidence for association of human bladder cancer with drinking-water chlorination disinfection by-products” Journal of Toxicology and Environmental Health, Part B. vol:18, 5, pp. 213-241, 2015.
- [18] T. E. Arbuckle, S. E. Hrudey, S. W. Krasner, J. R. Nuckols, “Assessing exposure in epidemiologic studies to disinfection by-products in drinking water: Report from an international workshop” Environmental Health Perspective, vol:110, 1, pp. 53–60, 2002.
- [19] R. J. Bull, L. S. Birnbaum, K. P. Cantor, J. B. Rose, B.E. Butterworth, R. Pergram, J. Tuomisto, “Water chlorination: essential process or cancer hazard” Toxicology Science, vol: 28, pp.155–166, 1995.
- [20] K. S. Crump, H. A. Guess, “Drinking water and cancer review of recent epidemiological findings and assessment of risks” Annual Review Public Health, vol: 3, pp. 339–57, 1982.
- [21] R. L. Calderon, “The epidemiology of chemical contaminants of drinking water” Food Chemical Toxicology, vol: 38, 12, pp.13–20, 2000.
- [22] D. Baytak, A. Sofuoglu, F. Inal, S. C. Sofuoglu, “Seasonal variation in drinking water concentrations of disinfection by-products in Izmir and associated human health risks” Science of the Total Environmental, vol: 407, 1, pp: 286-296, 2008.
- [23] Y. Wang, G. Zhu, B. Engel, “Health risk assessment of trihalomethanes in water treatment plants in Jiangsu Province, China” Ecotoxicology and Environmental Safety, vol: 170, pp. 346-354, 2019.
- [24] W. Gan, W. Guo, J. Mo, Y. He, Y. Liu, W. Liu, X. Yang, “The occurrence of disinfection by-products in municipal drinking water in China's Pearl River Delta and a multi-pathway cancer risk assessment” Science of the Total Environmental, vol: 447, pp. 108-115, 2013.
- [25] C. P. Weisel, H. Kim, P. Haltmeier, J. B. Klotz, “Exposure estimates to disinfection by-products of chlorinated drinking water” Environmental Health Perspective, vol: 107, 2, pp. 103-110, 1999.
- [26] T. Sirivedhin, K. A. Gray, “Comparison of the disinfection by-product formation potentials between a wastewater effluent and surface waters, Water Research, vol: 39, 6, pp. 1025-1036, 2005.
- [27] D. Zheng, R. C. Andrews, S. A. Andrews, L. Taylor-Edmonds, “Effects of coagulation on the removal of natural organic matter, genotoxicity and precursors to halogenated furanone, Water Research, vol:70, pp. 118-129, 2015.
- [28] B. Bolto, D. Dixon, R. Eldridge, S. King, K. Linge, “Removal of natural organic matter by ion exchange, Water Research, vol: 36, 20, pp. 5057-5065, 2002.
- [29] M. M. T. Khan, Z. Lewandowski, S. Takizawa, K. Yamada, H. Katayama, K. Yamamoto, S. Ohgaki, “Continuous and efficient removal of THMs from river water using MF membrane combined with high dose of PAC, Desalination, vol: 249, 2, pp. 713-720, 2009.
- [30] United States Environmental Protection Agency (USEPA), Guidelines for carcinogen risk assessment, Risk assessment forum, Washington DC, 2005.
- [31] B. Tokmak, G. Capar, F. B. Dilek, U. Yetis, “Trihalomethanes and associated potential cancer risks in the water supply in Ankara, Turkey, Environmental Research, vol: 96, 3, pp. 345-352, 2004
- [32] G. S. Wang, Y. C. Deng, T. F. Lin, “Cancer risk assessment from trihalomethanes in drinking water, Science of Total Environment, vol: 387, 1-3, pp. 86-95, 2007.
- [33] S. Liu, Z. Zhu, C. Fan, Y. Qiu, J. Zhao, “Seasonal variation effects on the formation of trihalomethane during chlorination of water from Yangtze River and associated cancer risk assessment, Journal Environmental Science, vol:23, 9, pp. 1503–1511, 2011.
- [34] N. Wang, Y. Zhu, “Empirical analysis of the factors affecting life expectancy in China” Commercial Economy, vol: 3, pp. 21–23, 2014.
- [35] Turkey Statistical Institute (TUIK), New Bulletin 2017, 22 June 2020 [Online], available:http://www.tuik.gov.tr/PreHaberBultenleri.do;jsessionid=DVvxhxqb321PZgscMkXhNKCT7yvnTnWYC2LJSgLGBlkr5WLqFxGp!1247757447?id=24640.
- [36] L. B. Gratt, Air toxic risk assessment and management, New York, NY’ Van Nostrand Reinhold, 1996.
- [37] X. Xu, T. M. Mariano, J. D. Laskin, C. P. Weisel, “Percutaneous absorption of trihalomethanes, haloacetic acids, and haloketones” Toxicology and Applied Pharmacology, vol:184, 1, pp.19-26, 2002.
- [38] C. Legay, M. J. Rodriguez, R. Sadiq, J. B. Sérodes, P. Levallois, F. Proulx, “Spatial variations of human health risk associated with exposure to chlorination by-products occurring in drinking water” Journal of Environmental Management, vol. 92, 3, pp. 892-901, 2011.
- [39] H. Amjad, I. Hashmi, M. S. U. Rehman, M. A. Awan, S. Ghaffar, Z. Khan, “Cancer and non-cancer risk assessment of trihalomethanes in urban drinking water supplies of Pakistan” Ecotoxicology and Environmental Safety, vol:91, pp: 25-31, 2013.
- [40] J. Lee, E. S. Kim, B. S. Roh, S. W. Eom, K. D. Zoh, “Occurrence of disinfection by-products in tap water distribution systems and their associated health risk” Environmental Monitoring and Assessment, vol:185, 9, pp. 7675-7691, 2013.
- [41] M. Okamoto, M. Sato, Y. Shodai, M. Kamijo, “Identifying the physical properties of showers that influence user satisfaction to aid in developing water-saving showers” Water Research, vol:7, 8, pp. 4054-4062, 2015.
- [42] The United States Environmental Protection Agency (USEPA), Edition of the drinking water standards and health advisories, Office of water U.S. Environ. Protect. Agency. Washington, DC, 2011.
- [43] J. S. Hammonds, F. O. Hoffman, S. M. Bartell, “Environmental restoration program, An introductory guide to uncertainty analysis in environmental and health risk assessment” Senes Oak Ridge, Inc. TN. USA, 1994.
- [44] United States Environmental Protection Agency (USEPA). Risk assessment guidance for superfund—Vol. I, Human health evaluation manual (Part D, Standardized planning, reporting and review of superfund risk assessments), Office of emergency and remedial response. Washington, DC, 2001.
- [45] C. H. Hsu, W. L. Jeng, R. M. Chang, L. C. Chieng, B. C. Han, “Estimation of potential lifetime cancer risks for trihalomethanes from consuming chlorinated drinking water in Taiwan” Environmental Research, vol: 85, pp.77–82, 2001.
- [46] M. Kumari, S. K. Gupta, B. K. Mishra, “Multi-exposure cancer and non-cancer risk assessment of trihalomethanes in drinking water supplies–a case study of Eastern region of India” Ecotoxicology and Environmental Safety, vol: 113, pp. 433-438, 2015.
- [47] M. Basu, S. K. Gupta, G. Singh, U. Mukhopadhyay, “Multi-route risk assessment from trihalomethanes in drinking water supplies” Environmental Monitoring and Assessment, vol: 178, 1-4, pp.121-134, 2011.
- [48] Z. Karim, M. Mumtaz, T. Kamal, “Health risk assessment of trihalomethanes of tap water in Karachi, Pakistan” Journal Chemical Society, vol:33, pp. 215–219, 2011.
- [49] J. K. Mahato, S. K. Gupta, “Advanced oxidation of Trihalomethane (THMs) precursors and season-wise multi-pathway human carcinogenic risk assessment in Indian drinking water supplies” Process Safety and Environmental Protection, vol:159, pp. 996-1007, 2022
- [50] E. S. I. Mishaqa, E. K. Radwan, M. B. M.Ibrahim, T. A. Hegazy, M. S. Ibrahim, “Multi-exposure human health risks assessment of trihalomethanes in drinking water of Egypt” Environmental Research, vol:207, 2022.
- [51] M. Mosaferi, M. Asadi, H. Aslani, A. Mohammadi, S. Abedi, S. Nemati Mansour, S. Maleki, “Temporospatial variation and health risk assessment of trihalomethanes (THMs) in drinking water (northwest Iran)” Environmental Science and Pollution Research, vol:28-7, pp. 8168-8180. 2021
- [52] A. Mohammadi, M. Faraji, A. Ebrahimi, S. Nemati, A. Abdolahnejad, M. Miri, “Comparing THMs level in old and new water distribution systems; seasonal variation and probabilistic risk assessment” Ecotoxicology and Environmental Safety, vol:192, 2020.
- [53] M. Kumari, S. K. Gupta, “Cumulative human health risk analysis of trihalomethanes exposure in drinking water systems” Journal of Environmental Management, vol:321, 2022.
Cancer Risk Analysis in Untreated and Photocatalytic Treated Water Containing THM
Yıl 2023,
Cilt: 27 Sayı: 2, 428 - 441, 30.04.2023
Cemil Örgev
,
Pınar Nazire Tanattı
,
Hülya Demirel
,
İsmail Ayhan Şengil
Öz
In this study, cancer risk analysis was investigated in untreated trihalomethanes (THMs) containing water using synthetic THM solution and after photocatalytic treatment with TiO2 and ZnO of this water. Trace amounts of disinfection by-products remain in the water. In this study, cancer risk assessment was investigated water containing trihalomethanes (THMs) constituted with synthetic THM solution and after the photocatalytic treatment of this water, the cancer risk was determined depending on the presence of THM in the water. With the photocatalytic treatment method using ZnO and nano TiO2 particles, THM removal was studied with synthetic water with an initial concentration of 300 µg/L. In the ZnO-catalyzed process chloroform 25 µg/L, BDCM 2.4 µg/L and DBCM 35 µg/L were found. However, in the TiO2-catalyzed process, chloroform 49 µg/L and DBCM 28 µg/L were obtained. The cancer risk analysis and the hazard index of THMs through oral, dermal and inhalation ingestion from these waters were evaluated. Comparing the three different pathways, humans have a higher risk of cancer through oral ingestion than dermal and inhalation pathways. It has been determined that the cancer risk for ZnO treated water was reduced by 62% and for TiO2 treated water by 69% when THMs by oral ingestion have examined compared to untreated water in cancer risk analysis. The cancer risks of oral ingestion are determined as acceptable low risk, but the cancer risk of THMs through dermal ingestion from dibromochloromethane plays an essential role in this study.
Proje Numarası
Projeden veriler üeretilmemiştir.
Kaynakça
- [1] W. E. Elshorbagy, H. Abu-Qadais, M. K. Elsheamy, “Simulation of THM species in water distribution systems” Water Research, vol:34, issue 13, pp. 3431- 3439, 2000.
- [2] V. Uyak, K. Ozdemir, I. Toroz, “Multiple linear regression modeling of disinfection by-products formation in Istanbul drinking water reservoirs” Science of Total Environmental, vol: 378, pp. 269–280, 2007.
- [3] J. Zhang, J. Liu, C. S. He, C, Qian, Y. M, “Formation of iodo-trihalomethanes (I-THMs) during disinfection with chlorine or chloramine: Impact of UV/H2O2 pre-oxidation” Science of Total Environmental, pp. 640–641, 2018.
- [4] G. Hua, S. Yeats, “Control of trihalomethanes in wastewater treatment” Fla. Water Resource Journal, vol: 4, pp. 6-12, 2010.
- [5] A. Marcoux, G. Pelletier, C. Legay, C. Bouchard, M. J. Rodriguez, “Behavior of nonregulated disinfection by-products in water following multiple chlorination points during treatment” Science of Total Environmental, vol: 586, pp. 870–878, 2017.
- [6] A. M. Tugulea, R. Aranda-Rodriguez, D. Bérubé, M. Giddings, F. Lemieux, J. Hnatiw, F. Breton, “The influence of precursors and treatment process on the formation of Iodo-THMs in Canadian drinking water” Water Research, vol: 130, pp. 215-223, 2018.
- [7] T. Priya, P. Prakash, B. K. Mishra, “Understanding the coagulant activity of zirconium oxychloride to control THMs formation using response surface methodology” Ecotoxicology and Environmental Safety, vol:159, pp. 28-37, 2018.
- [8] E. M. Rodríguez, M. V. Gordillo, A. Rey, F. J. Beltrán, “Impact of TiO2/UVA photocatalysis on THM formation potential” Catalysis Today, vol: 313, pp.167-174, 2018.
- [9] S. K. Golfinopoulos, G. B. Arhonditsis, “Multiple regression models: a methodology for evaluating trihalomethane concentrations in drinking water from raw water characteristics” Chemosphere, vol: 47(9), pp.1007-1018, 2002.
- [10] V. Uyak, I. Toroz, S. Meric, “Monitoring and modeling of trihalomethanes (THMs) for a water treatment plant in Istanbul” Desalination, vol: 176(1-3), pp.91-101, 2005.
- [11] S. W. Krasner, M. J. McGuire, J. G. Jacangelo, N. L. Patania, K. M. Regan, A. E. Marco, “Occurrence of disinfection by-products in US drinking water” Journal Water Works Association, vol: 81, 8, pp. 41–53, 2001.
- [12] United States Environmental Protection Agency (USEPA). Guidelines for carcinogen risk assessment. Risk Assessment Forum. Washington DC. NCEA-F-0644 (Revised draft), 1999.
- [13] T. Priya, B. K. Mishra, “Enzyme mediated chloroform biotransformation and quantitative cancer risk analysis of trihalomethanes exposure in South East Asia” Exposure and Health, vol:9, 1, pp.61-75. 2017.
- [14] V. Uyak, “Multi-pathway risk assessment of trihalomethanes exposure in Istanbul drinking water supplies” Environmental International, vol: 32, 1, pp.12-21, 2006.
- [15] S. C. Lee, H. Guo, S. M. J. Lam, S. L. A. Lau, “Multipathway risk assessment on disinfection by-products of drinking water in Hong Kong” Environmental Research, vol: 94, 1, pp. 47-56, 2004.
- [16] A. Siddique, S. Saied, M. Mumtaz, M. M. Hussain, H. A. Khwaja, “Multipathways human health risk assessment of trihalomethane exposure through drinking water” Ecotoxicology, and Environmental Safety, vol: 116, pp. 129-136, 2015.
- [17] S. E. Hrudey, L. C. Backer, A. R. Humpage, S. W. Krasner, D. S. Michaud, L. E. Moore, B. D. Stanford, “Evaluating evidence for association of human bladder cancer with drinking-water chlorination disinfection by-products” Journal of Toxicology and Environmental Health, Part B. vol:18, 5, pp. 213-241, 2015.
- [18] T. E. Arbuckle, S. E. Hrudey, S. W. Krasner, J. R. Nuckols, “Assessing exposure in epidemiologic studies to disinfection by-products in drinking water: Report from an international workshop” Environmental Health Perspective, vol:110, 1, pp. 53–60, 2002.
- [19] R. J. Bull, L. S. Birnbaum, K. P. Cantor, J. B. Rose, B.E. Butterworth, R. Pergram, J. Tuomisto, “Water chlorination: essential process or cancer hazard” Toxicology Science, vol: 28, pp.155–166, 1995.
- [20] K. S. Crump, H. A. Guess, “Drinking water and cancer review of recent epidemiological findings and assessment of risks” Annual Review Public Health, vol: 3, pp. 339–57, 1982.
- [21] R. L. Calderon, “The epidemiology of chemical contaminants of drinking water” Food Chemical Toxicology, vol: 38, 12, pp.13–20, 2000.
- [22] D. Baytak, A. Sofuoglu, F. Inal, S. C. Sofuoglu, “Seasonal variation in drinking water concentrations of disinfection by-products in Izmir and associated human health risks” Science of the Total Environmental, vol: 407, 1, pp: 286-296, 2008.
- [23] Y. Wang, G. Zhu, B. Engel, “Health risk assessment of trihalomethanes in water treatment plants in Jiangsu Province, China” Ecotoxicology and Environmental Safety, vol: 170, pp. 346-354, 2019.
- [24] W. Gan, W. Guo, J. Mo, Y. He, Y. Liu, W. Liu, X. Yang, “The occurrence of disinfection by-products in municipal drinking water in China's Pearl River Delta and a multi-pathway cancer risk assessment” Science of the Total Environmental, vol: 447, pp. 108-115, 2013.
- [25] C. P. Weisel, H. Kim, P. Haltmeier, J. B. Klotz, “Exposure estimates to disinfection by-products of chlorinated drinking water” Environmental Health Perspective, vol: 107, 2, pp. 103-110, 1999.
- [26] T. Sirivedhin, K. A. Gray, “Comparison of the disinfection by-product formation potentials between a wastewater effluent and surface waters, Water Research, vol: 39, 6, pp. 1025-1036, 2005.
- [27] D. Zheng, R. C. Andrews, S. A. Andrews, L. Taylor-Edmonds, “Effects of coagulation on the removal of natural organic matter, genotoxicity and precursors to halogenated furanone, Water Research, vol:70, pp. 118-129, 2015.
- [28] B. Bolto, D. Dixon, R. Eldridge, S. King, K. Linge, “Removal of natural organic matter by ion exchange, Water Research, vol: 36, 20, pp. 5057-5065, 2002.
- [29] M. M. T. Khan, Z. Lewandowski, S. Takizawa, K. Yamada, H. Katayama, K. Yamamoto, S. Ohgaki, “Continuous and efficient removal of THMs from river water using MF membrane combined with high dose of PAC, Desalination, vol: 249, 2, pp. 713-720, 2009.
- [30] United States Environmental Protection Agency (USEPA), Guidelines for carcinogen risk assessment, Risk assessment forum, Washington DC, 2005.
- [31] B. Tokmak, G. Capar, F. B. Dilek, U. Yetis, “Trihalomethanes and associated potential cancer risks in the water supply in Ankara, Turkey, Environmental Research, vol: 96, 3, pp. 345-352, 2004
- [32] G. S. Wang, Y. C. Deng, T. F. Lin, “Cancer risk assessment from trihalomethanes in drinking water, Science of Total Environment, vol: 387, 1-3, pp. 86-95, 2007.
- [33] S. Liu, Z. Zhu, C. Fan, Y. Qiu, J. Zhao, “Seasonal variation effects on the formation of trihalomethane during chlorination of water from Yangtze River and associated cancer risk assessment, Journal Environmental Science, vol:23, 9, pp. 1503–1511, 2011.
- [34] N. Wang, Y. Zhu, “Empirical analysis of the factors affecting life expectancy in China” Commercial Economy, vol: 3, pp. 21–23, 2014.
- [35] Turkey Statistical Institute (TUIK), New Bulletin 2017, 22 June 2020 [Online], available:http://www.tuik.gov.tr/PreHaberBultenleri.do;jsessionid=DVvxhxqb321PZgscMkXhNKCT7yvnTnWYC2LJSgLGBlkr5WLqFxGp!1247757447?id=24640.
- [36] L. B. Gratt, Air toxic risk assessment and management, New York, NY’ Van Nostrand Reinhold, 1996.
- [37] X. Xu, T. M. Mariano, J. D. Laskin, C. P. Weisel, “Percutaneous absorption of trihalomethanes, haloacetic acids, and haloketones” Toxicology and Applied Pharmacology, vol:184, 1, pp.19-26, 2002.
- [38] C. Legay, M. J. Rodriguez, R. Sadiq, J. B. Sérodes, P. Levallois, F. Proulx, “Spatial variations of human health risk associated with exposure to chlorination by-products occurring in drinking water” Journal of Environmental Management, vol. 92, 3, pp. 892-901, 2011.
- [39] H. Amjad, I. Hashmi, M. S. U. Rehman, M. A. Awan, S. Ghaffar, Z. Khan, “Cancer and non-cancer risk assessment of trihalomethanes in urban drinking water supplies of Pakistan” Ecotoxicology and Environmental Safety, vol:91, pp: 25-31, 2013.
- [40] J. Lee, E. S. Kim, B. S. Roh, S. W. Eom, K. D. Zoh, “Occurrence of disinfection by-products in tap water distribution systems and their associated health risk” Environmental Monitoring and Assessment, vol:185, 9, pp. 7675-7691, 2013.
- [41] M. Okamoto, M. Sato, Y. Shodai, M. Kamijo, “Identifying the physical properties of showers that influence user satisfaction to aid in developing water-saving showers” Water Research, vol:7, 8, pp. 4054-4062, 2015.
- [42] The United States Environmental Protection Agency (USEPA), Edition of the drinking water standards and health advisories, Office of water U.S. Environ. Protect. Agency. Washington, DC, 2011.
- [43] J. S. Hammonds, F. O. Hoffman, S. M. Bartell, “Environmental restoration program, An introductory guide to uncertainty analysis in environmental and health risk assessment” Senes Oak Ridge, Inc. TN. USA, 1994.
- [44] United States Environmental Protection Agency (USEPA). Risk assessment guidance for superfund—Vol. I, Human health evaluation manual (Part D, Standardized planning, reporting and review of superfund risk assessments), Office of emergency and remedial response. Washington, DC, 2001.
- [45] C. H. Hsu, W. L. Jeng, R. M. Chang, L. C. Chieng, B. C. Han, “Estimation of potential lifetime cancer risks for trihalomethanes from consuming chlorinated drinking water in Taiwan” Environmental Research, vol: 85, pp.77–82, 2001.
- [46] M. Kumari, S. K. Gupta, B. K. Mishra, “Multi-exposure cancer and non-cancer risk assessment of trihalomethanes in drinking water supplies–a case study of Eastern region of India” Ecotoxicology and Environmental Safety, vol: 113, pp. 433-438, 2015.
- [47] M. Basu, S. K. Gupta, G. Singh, U. Mukhopadhyay, “Multi-route risk assessment from trihalomethanes in drinking water supplies” Environmental Monitoring and Assessment, vol: 178, 1-4, pp.121-134, 2011.
- [48] Z. Karim, M. Mumtaz, T. Kamal, “Health risk assessment of trihalomethanes of tap water in Karachi, Pakistan” Journal Chemical Society, vol:33, pp. 215–219, 2011.
- [49] J. K. Mahato, S. K. Gupta, “Advanced oxidation of Trihalomethane (THMs) precursors and season-wise multi-pathway human carcinogenic risk assessment in Indian drinking water supplies” Process Safety and Environmental Protection, vol:159, pp. 996-1007, 2022
- [50] E. S. I. Mishaqa, E. K. Radwan, M. B. M.Ibrahim, T. A. Hegazy, M. S. Ibrahim, “Multi-exposure human health risks assessment of trihalomethanes in drinking water of Egypt” Environmental Research, vol:207, 2022.
- [51] M. Mosaferi, M. Asadi, H. Aslani, A. Mohammadi, S. Abedi, S. Nemati Mansour, S. Maleki, “Temporospatial variation and health risk assessment of trihalomethanes (THMs) in drinking water (northwest Iran)” Environmental Science and Pollution Research, vol:28-7, pp. 8168-8180. 2021
- [52] A. Mohammadi, M. Faraji, A. Ebrahimi, S. Nemati, A. Abdolahnejad, M. Miri, “Comparing THMs level in old and new water distribution systems; seasonal variation and probabilistic risk assessment” Ecotoxicology and Environmental Safety, vol:192, 2020.
- [53] M. Kumari, S. K. Gupta, “Cumulative human health risk analysis of trihalomethanes exposure in drinking water systems” Journal of Environmental Management, vol:321, 2022.