İleri Glikasyon Son Ürünlerinin Gebelik Üzerine Etkisi

Abstract

İleri glikasyon son ürünleri, çok çeşitli yapısal ve fonksiyonel özelliklere sahip, herhangi bir canlı organizmada oluşan ve enzimatik olmayan bileşiklerdir. İleri glikasyon son ürünleri reseptöre veya doğrudan hücre dışı matrikse bağlanır ve hücre dışı moleküllerin istenilen şekilde çalışmamasına yol açar. İleri glikasyon son ürünleri ve reseptör etkileşimleri inflamasyon, oksidatif stres, vasküler hiperpermeabilite ile sonuçlanarak vaskülatürde homeostatik bozulmaya neden olur. Oksidatif bozukluklar ve inflamasyon; gestasyonel diyabet, preeklemsi, erken doğum, erken membran rüptürü ve tekrarlayan gebelik kaybı gibi olumsuz gebelik sonuçları ile ilişkilidir. Literatüre bakıldığında inflamasyon fetal membranları zayıflatarak erken rüptüre ve erken doğuma sebep olabilmektedir. İleri glikasyon son ürünleri düzeyinin yüksek olması ve bozulmuş metabolik durumun gebelikte preeklemsinin fizyopatolojisine etki ettiği gestasyonel diabetes mellitus ve tekrarlayan gebelik kayıpları ile ilişkilendirildiği belirtilmektedir. Çalışmalar, gebelik ve AGE’lerin düzeyi arasında güçlü bir ilişki olduğunu göstermektedir. AGE’ler ve gebelik arasındaki nedensel ilişkiyi bulmak için daha iyi tasarlanmış çalışmalar yapılması literatür açısından önem taşımaktadır.

Keywords

• Gebelik
• gestasyonel diyabetes mellitus
• ileri glikasyon son ürünleri
• oksidatif stres
• preeklemsi

The Effect of Advanced Glycation End Products on Pregnancy

Abstract

Advanced glycation end products are non-enzymatic compounds which have a wide variety of structural and functional properties and which occur in any living organism. Advanced glycation end products bind to the receptor or directly to the extracellular matrix and cause the extracellular molecules to malfunction. Advanced glycation end products and receptor interactions result in inflammation, oxidative stress, and vascular hyper permeability, causing homeostatic deterioration in the vasculature. Oxidative disorders and inflammation; gestational diabetes is associated with adverse pregnancy outcomes such as preeclampsia, preterm birth, premature rupture of membranes, and recurrent pregnancy loss. Looking at the literature, inflammation may weaken fetal membranes and cause premature rupture and preterm delivery. It is stated that high levels of advanced glycation end products and impaired metabolic status affect the physiopathology of preeclampsia during pregnancy and are associated with gestational diabetes mellitus and recurrent pregnancy losses. Studies show a strong correlation between pregnancy and the level of AGEs. It is important for the literature to conduct better designed studies to find the causal relationship between AGEs and pregnancy.

Keywords

• Advanced glycation end-products
• gestational diabetes mellitus
• oxidative stress
• preeclampsia
• pregnancy

References

1. 1. Zhu JL, Cai YQ, Long SL, Chen Z, Mo ZC. The role of advanced glycation end products in human infertility. Life Science. 2020;255:117830. doi:10.1016/j.lfs.2020.117830
2. 2. Peyroux J, Sternberg M. Advanced glycation endproducts (AGEs): Pharmacological inhibition in diabetes. Pathologie Biologie (Paris). 2006;54:405-419.
3. 3. Uribarri J, Woodruff S, Goodman S, et al. Advanced glycation end products in foods and a practical guide to their reduction in the diet. Journal of the American Dietetic Association. 2010;110(6):911-16.e12. doi:10.1016/j.jada.2010.03.018
4. 4. Sisay M, Edessa D, Ali T, Mekuria AN, Gebrie A. The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis. PLoS One. 2020;15(10):e0240382. doi:10.1371/journal.pone.0240382
5. 5. Jud P, Sourij H. Therapeutic options to reduce advanced glycation end products in patients with diabetes mellitus: A review. Diabetes Research and Clinical Practice. 2019;148:54-63. doi:10.1016/j.diabres.2018.11.016
6. 6. Yılmaz B, Karabudak E. Besinlerdeki ileri glikasyon son ürünleri ve azaltma yöntemleri. Beslenme ve Diyet Dergisi. 2016;44(3):280-288.
7. 7. Sharma R, Agarwal A, Rohra VK, Assidi M, Abu-Elmagd M, Turki RF. Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring. Reproductive Biology and Endocrinology. 2015;13:35. doi:10.1186/s12958-015-0028-x
8. 8. Mericq V, Piccardo C, Cai W, et al. Maternally transmitted and food-derived glycotoxins: a factor preconditioning the young to diabetes? Diabetes Care. 2010;33(10):2232-2237. doi:10.2337/dc10-1058

9. 9. Palanissami G, Paul SFD. RAGE and its ligands: Molecular interplay between glycation, ınflammation, and hallmarks of cancer-a review. Horm Cancer. 2018;9(5):295-325. doi:10.1007/s12672-018-0342-9
10. 10. Chekir C, Nakatsuka M, Noguchi S, et al. Accumulation of advanced glycation end products in women with preeclampsia: possible involvement of placental oxidative and nitrative stress. Placenta. 2006;27(2-3): 225-233. doi:10.1016/j.placenta.2005.02.016
11. 11. Germanová A, Koucký M, Hájek Z, Parízek A, Zima T, Kalousová M. Soluble receptor for advanced glycation end products in physiological and pathological pregnancy. Clin Biochem. 2010;43(4-5):442-446. doi:10.1016/j.clinbiochem.2009.11.002
12. 12. Verma N, Manna SK. Advanced glycation end products (AGE) potently induce autophagy through activation of RAF protein kinase and nuclear factor κB (NF-κB). Journal of Biological Chemistry. 2016;291(3):1481-1491. doi:10.1074/jbc.M115.667576
13. 13. Parmaksız İ. Diyabet komplikasyonlarında ileri glikasyon son ürünleri. Marmara Medical Journal. 2011; 24(3). doi:10.5472/MMJ.2011.0.2037.1
14. 14. Harsem NK, Braekke K, Torjussen T, Hanssen K, Staff AC. Advanced glycation end products in pregnancies complicated with diabetes mellitus or preeclampsia. Hypertens Pregnancy. 2008;27(4):374-386. doi:10.1080/10641950802000968
15. 15. Aziz ZNE, Baban RS, Al-Habib MFM. Advanced Glycation End Products (AGEs) level and insulin resistance in women with gestational diabetes. International Journal of Advance Research. 2015;3(4):416-23.
16. 16. Belfiore A, Malaguarnera R, Vella V, et al. Insulin receptor ısoforms in physiology and disease: An updated view. Endocr Rev. 2017;38(5):379-431. doi:10.1210/er.2017-00073
17. 17. Luevano-Contreras C, Chapman-Novakofski K. Dietary advanced glycation end products and aging. Nutrients. 2010;2(12):1247–1265. doi:10.3390/nu2121247
18. 18. Edeas M, Attaf D, Mailfert AS, Joubet R. Maillard reaction, mitochondria and oxidative stress: Potential role of antioxidants. Pathologie Biologie (Paris). 2010;58(3):220–225. doi:10.1016/j.patbio.2009.09.011
19. 19. Hachiya H, Miura Y, Inoue K, Park KH, Takeuchi M, Kubota K. Advanced glycation end products impair glucose-induced insulin secretion from rat pancreatic beta-cells. J Hepatobiliary Pancreat Sci. 2014;21(2):134–141. doi:10.1002/jhbp.12
20. 20. Orr SK, Dachner N, Frank L, Tarasuk V. Relation between household food insecurity and breastfeeding in Canada. CMAJ. 2018;190(11):E312-E319. doi:10.1503/cmaj.170880
21. 21. Challis JR, Lockwood CJ, Myatt L, Norman JE, Strauss JF, Petraglia F. Inflammation and pregnancy. Reproductive Sciences. 2009;16(2):206–215. doi:10.1177/1933719108329095
22. 22. Cuffe JS, Xu ZC, Perkins AV. Biomarkers of oxidative stress in pregnancy complications. Biomarkers in Medicine. 2017;11(3):295-306. doi:10.2217/bmm-2016-0250
23. 23. Li S, Yang H. Relationship between advanced glycation end products and gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2019;32(17):2783-2789. doi:10.1080/14767058.2018.1449201
24. 24. American Diabetes Association. 2. Classification and diagnosis of diabetes: standards of medical care in diabetes. Diabetes car. 2018;41(1):S13-S27
25. 25. Perinatoloji Uzmanları Derneği. (2019) (PUDER). http://puder.org.tr/kilavuzlar/
26. 26. Damm P, Houshmand-Oeregaard A, Kelstrup L, Lauenborg J, Mathiesen ER, Clausen TD. Gestational diabetes mellitus and long-term consequences for mother and offspring: a view from Denmark. Diabetologia. 2016;59(7):1396-1399. doi:10.1007/s00125-016-3985-5
27. 27. Plows JF, Stanley JL, Baker PN, Reynolds CM, Vickers MH. The pathophysiology of gestational diabetes mellitus. International Journal of Molecular Sciences. 2018;19(11):3342. doi:10.3390/ijms19113342
28. 28. Vargas-Terrones M, Nagpal TS, Barakat R. Impact of exercise during pregnancy on gestational weight gain and birth weight: An overview. Braz J Phys Ther. 2019;23(2):164–169. doi:10.1016/j.bjpt.2018.11.012
29. 29. Poprawski G, Pietryga M, Zawiejska A, Iciek R, Wender-Ozegowska E, Brazert J. Wpływ wyrównania metabolicznego na parametry krazenia maciczno-łozyskowego w ciazy powikłanej nadciśnieniem ciazowym i stanem przedrzucawkowym u ciezarnych z cukrzyca przedciazowa [The impact of metabolic control on uteroplacental circulation parameters in pregnancies complicated by gestational hypertension and/or preeclampsia in pregnant women with pregestational diabetes]. Ginekol Pol. 2015;86(11):811-820. doi:10.17772/gp/59271
30. 30. Guosheng L, Hongmei S, Chuan N, Haiying L, Xiaopeng Z, Xianqiong L. The relationship of serum AGE levels in diabetic mothers with adverse fetal outcome. J Perinatol. 2009;29(7):483-488. doi:10.1038/jp.2009.12
31. 31. Bernea EG, Antohe F, Mıhaı A, Ionescu-Tirgovıste C. Oxidative stress and gestational diabetes mellitus. The effects of supplements on oxidative stress. Proc Rom Acad Ser B. 2018;20(2):121-131.
32. 32. Perrone A, Giovino A, Benny J, Martinelli F. Advanced glycation end products (AGEs): Biochemistry, signaling, analytical methods, and epigenetic effects. Oxidative Medicine and Cellular Longevity. 2020;3818196:18. doi:10.1155/2020/3818196
33. 33. Wells JCK, Figueiroa JN, Alves JG. Maternal pelvic dimensions and neonatal size: Implications for growth plasticity in early life as adaptation. Evol Med Public Health. 2018;2017(1):191-200. doi: 10.1093/emph/eox016
34. 34. Bartakova V, Kollarova R, Kuricova K, Sebekova K, Belobradkova J, Kankova K. Serum carboxymethyl-lysine, a dominant advanced glycation end product, is increased in women with gestational diabetes mellitus. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016;160(1):70–75. doi:10.5507/bp.2015.045
35. 35. Boutzios G, Livadas S, Piperi C, et al. Polycystic ovary syndrome offspring display increased oxidative stress markers comparable to gestational diabetes offspring. Fertil Steril. 2013;99(3):943–950. doi:10.1016/j.fertnstert.2012.10.050
36. 36. Tang X, Qin Q, Xie X, He P. Protective effect of sRAGE on fetal development in pregnant rats with gestational diabetes mellitus. Cell Biochem Biophys. 2015;71(2):549–556. doi:10.1007/s12013-014-0233-9
37. 37. Assefa NE, Berhe H, Girma F, et al. Risk factors of premature rupture of membranes in public hospitals at Mekele city, Tigray, a case control study. BMC Pregnancy and Childbirth. 2018;18(1):1-7. doi:10.1186/s12884-018-2016-6
38. 38. Bouvier D, Forest JC, Blachon L, et al. Risk factors and outcomes of preterm premature rupture of membranes in a cohort of 6968 pregnant women prospectively recruited. Journal of Clinical Medicine. 2019;8(11):1987. doi:10.3390/jcm8111987
39. 39. Forde B, Mounira H. Unique considerations: Preterm prelabor rupture of membranes in the setting of fetal surgery and higher order pregnancies. Obstet Gynecol Clin North Am. 2020;47(4):653-669. doi:10.1016/j.ogc.2020.08.008
40. 40. Modi BP, Teves ME, Pearson LN, et al. Mutations in fetal genes involved in innate immunity and host defense against microbes increase risk of preterm premature rupture of membranes (PPROM). Molecular Genetics & Genomic Medicine. 2017;5(6):720-729. doi: 10.1002/mgg3.330
41. 41. Mishra S, Joshi M. Premature rupture of membrane-risk factors: A clinical study. Intrnational Journal of Contemporary Medical Research. 2017;4(1),146-148.
42. 42. Ramasamy R, Vannucci SJ, Yan SS, Herold K, Yan SF, Schmidt AM. Advanced glycation end products and RAGE: A common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology. 2005;15(7):16R–28R. doi:10.1093/glycob/cwi053
43. 43. Schmidt AM, Yan SD, Yan SF, Stern DM. The biology of the receptor for advanced glycation end products and its ligands. Biochim Biophsy Acta. 2000;1498(2–3):99–111. doi:10.1016/s0167-4889(00)00087-2
44. 44. Dutta EH, Behnia F, Boldogh I, et al. Oxidative stress damage-associated molecular signaling pathways differentiate spontaneous preterm birth and preterm premature rupture of the membranes. Mol Hum Reprod. 2016;22(2):143-157. doi:10.1093/molehr/gav074
45. 45. Menon R, Richardson LS. Preterm prelabor rupture of the membranes: A disease of the fetal membranes. Seminars in Perinatology. 2017;41(7):409-419. doi:10.1053/j.semperi.2017.07.012
46. 46. Park JW, Park KH, Jung EY. Clinical significance of histologic chorioamnionitis with a negative amniotic fluid culture in patients with preterm labor and premature membrane rupture. PloS One. 2017;12(3);e0173312. doi:10.1371/journal.pone.0173312
47. 47. Romero R, Miranda J, Chaemsaithong P, et al. Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2015;28(12):1394-1409. doi:10.3109/14767058.2014.958463
48. 48. Romero R, Miranda J, Chaiworapongsa T, et al. Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Reprod Immunol. 2014;72(5):458-474. doi:10.1111/aji.12296.
49. 49. D’Angelo G, Marseglia L, Granese R, et al. Different concentration of human cord blood HMGB1 according to delivery and labour: A pilot study. Cytokine. 2018;108:53-56. doi:10.1016/j.cyto.2018.03.019
50. 50. Naruse K, Sado T, Noguchi T, et al. Peripheral RAGE (receptor for advanced glycation endproducts)-ligands in normal pregnancy and preeclampsia: Novel markers of inflammatory response. J Reprod Immunol. 2012;93(2):69-74. doi:10.1016/j.jri.2011.12.003
51. 51. Rzepka R, Dołegowska B, Rajewska A, et al. Soluble and endogenous secretory receptors for advanced glycation end products in threatened preterm labor and preterm premature rupture of fetal membranes. Biomed Res Int. 2015;568042. doi:10.1155/2015/568042
52. 52. Bouvier D, Giguère Y, Blanchon L, et al. Study of sRAGE, HMGB1, AGE, and S100A8/A9 concentrations in plasma and in serum-extracted extracellular vesicles of pregnant women with preterm premature rupture of membranes. Front Physiol. 2020;11:609. doi:10.3389/fphys.2020.00609
53. 53. Kansu-Celik H, Tasci Y, Karakaya BK, Cinar M, Candar T, Caglar GS. Maternal serum advanced glycation end products level as an early marker for predicting preterm labor/PPROM: A prospective preliminary study. J Matern Fetal Neonatal Med. 2019;32(16):2758-2762. doi:10.1080/14767058.2018.1449202
54. 54. Warrington JP, George EM, Palei AC, Spradley FT, Granger JP. Recent advances in the understanding of the pathophysiology of preeclampsia. Hypertension. 2013;62:666‐673. doi:10.1161/HYPERTENSIONAHA.113.00588
55. 55. Freeman DJ, McManus F, Brown EA, et al. Short- and long-term changes in plasma inflammatory markers associated with preeclampsia. Hypertension. 2004;44(5):708-714. doi:10.1161/01.HYP.0000143849.67254.ca
56. 56. Von Versen-Hoeynck FM, Powers RW. Maternal-fetal metabolism in normal pregnancy and preeclampsia. Front Biosci. 2007;12:2457-2470. doi:10.2741/2247
57. 57. Guedes-Martins L, Matos L, Soares A, Silva E, Almeida H. AGEs, contributors to placental bed vascular changes leading to preeclampsia. Free Radic Res. 2013;47(1):70-80. doi:10.3109/10715762.2013.815347
58. 58. Chen W, Zhang Y, Yue C, et al. Accumulation of advanced glycation end products involved in inflammation and contributing to severe preeclampsia, in maternal blood, umbilical blood and placental tissues. Gynecol Obstet Invest. 2017;82(4):388–397. doi:10.1159/000448141
59. 59. García-Gómez E, Bobadilla-Bravo M, Díaz-Díaz E, et al. High plasmatic levels of advanced glycation end products are associated with metabolic alterations and ınsulin resistance in preeclamptic women. Curr Mol Med. 2020;20(9):751-759. doi:10.2174/1566524020666200220141414
60. 60. Xian N, Chen W, Zhang Y, Li J, Zhang N, Ye Y. Correlation of the expressions of advanced glycation end products and its receptor in serum and placenta with the pathogenesis of preeclampsia. Zhonghua Fu Chan Ke Za Zhi. 2015;50(7):493-499.
61. 61. Cooke CL, Brockelsby JC, Baker PN, Davidge ST. The receptor for advanced glycation end products (RAGE) is elevated in women with preeclampsia. Hypertens Pregnancy 2003;22:173–84. doi:10.1081/PRG-120021068.
62. 62. Royal College of Obstetricians and Gynaecologists. The investigation and treatment of couples with recurrent first-trimester and second-trimester miscarriage. 2011. https://www.rcog.org.uk/globalassets/documents/guidelines/gtg_17.pdf (Erişim tarihi: 23 Ağustos 2021).
63. 63. Shahine L, Lathi R. Recurrent pregnancy loss: Evaluation and treatment. Obstet Gynecol Clin North Am. 2015;42(1):117–34. doi:10.1016/j.ogc.2014.10.002
64. 64. Agarwal A, Aponte-Mellado A, Premkumar BJ, Shaman A, Gupta S. The effects of oxidative stress on female reproduction: A review. Reprod Biol Endocrinol. 2012;10:49. doi:10.1186/1477-7827-10-49
65. 65. Kwak-Kim J, Yang KM, Gilman-Sachs A. Recurrent pregnancy loss: A disease of inflammation and coagulation. Journal of Obstetrics and Gynaecology Research. 2009;35(4):609–622. doi:10.1111/j.1447-0756.2009.01079.x
66. 66. Ota K, Yamagishi S, Kim M, et al. Elevation of soluble form of receptor for advanced glycation end products (sRAGE) in recurrent pregnancy losses (RPL): Possible participation of RAGE in RPL. Fertility and Sterility. 2014;102(3):782-789. doi:10.1016/j.fertnstert.2014.06.010