Investigation on Photon Interaction Properties of Some Polymers Used in Production of Hydrogels

Year 2018, Volume: 13 Issue: 2, 97 - 107, 30.11.2018

Esra Kavaz

https://doi.org/10.29233/sdufeffd.453522

Cited By: 1

Abstract

Due to their excellent features and applications, hydrogels become so popular and are
used for fabricating contact lenses, cancer treatment, hygiene products, tissue engineering, drug
and delivery systems. Simultaneously use of hydrogels with radiotherapy is known to be effective
in protecting the healthy cells from high radiation. From this point on, it is necessary to know
radiation attenuation properties of compounds used in production of hydrogel. In the present
study, half value layer (HVL), effective atomic number (Zeff), effective electron density (Nel) and
energy absorption and exposure buildup factors (EABF and EBF) of eight hydrogel samples
(hyaluronic acid, chitosan, fibrin, dextran sulfate, pectin, alginic acid, chondroitin sulfate and
carrageenan) have been investigated. From the obtained results, it might be concluded that these
parameters depend on the elemental composition of the samples. It is seen that dextran sulfate has
most superior radiation absorption capacity while fibrin has the lowest when compared to other
samples.

Keywords

Hydrogel, Radiation, HVL, Effective atomic number, Buildup factor

Hidrojel Üretiminde Kullanılan Bazı Polimerlerin Foton Etkileşim Özelliklerinin İncelenmesi

Abstract

Mükemmel özellikleri ve uygulamaları nedeniyle, hidrojeller son derece popülerdir ve
kontakt lenslerin üretimi, kanser tedavisi, hijyen ürünleri, doku mühendisliği ve ilaç verme
sistemleri için kullanılır. Hidrojellerin radyoterapi ile eş zamanlı kullanımının, sağlıklı hücrelerin
yüksek radyasyondan korunmasında etkili olduğu bilinmektedir. Bu noktadan hareketle, hidrojel
üretiminde kullanılan bileşikerin radyasyon azaltma özelliklerini bilmek gereklidir. Bu çalışmada,
sekiz hidrojel örneğinin (aljinik asit, hiyalüronik asit, kitosan, fibrin, carrageenan, pektin,
kondroitin sülfat ve dekstran sülfat ) yarı değer kalınlığı (HVL), etkin atom numarası (Zeff), etkin
elektron yoğunluğu (Nel) ve enerji absorpsiyon ve maruz kalma kuvvetlendirme faktörleri (EABF
ve EBF) incelendi. Elde edilen sonuçlara göre, bu parametreler, numunelerin elementel
kompozisyonuna bağlı olup, diğer örnekler ile kıyaslandığında dekstran sülfatın daha üstün
radyasyon soğurma kapasitesine sahipken fibrinin en az olduğu görülebilir. 

Keywords

HVL, Hidrojel, Radyasyon, Etkin atom numarası, Kuvvetlendirme faktörü

References

• R. Korsmeyer, R. Gurny, E. Doelker, P. Buri and N. Peppas, “Mechanisms of solute release from porous hydrophilic polymers,” International Journal of Pharmaceutics, vol. 15(1), pp.25-35, May. 1983.
• A. D. Rao, E. J. Shin, S. E. Beck, C. Garrett, S.-H. Kim, N. J. Lee, E. Liapi, J. Wong, J. Herman, A. Narang, and K. Ding, “Demonstration of Safety and Feasibility of Hydrogel Marking of the Pancreas–Duodenum Interface for Image Guided Radiation Therapy (IGRT) in a Porcine Model: Implications in IGRT for Pancreatic Cancer Patients,” International Journal of Radiation Oncology*Biology*Physics, vol. 101, no. 3, pp. 640–645, 2018.
• N. Mariados, J. Sylvester, D. Shah, L. Karsh, R. Hudes, D. Beyer, S. Kurtzman, J. Bogart, R. A. Hsi, M. Kos, R. Ellis, M. Logsdon, S. Zimberg, K. Forsythe, H. Zhang, E. Soffen, P. Francke, C. Mantz, P. Rossi, T. Deweese, D. A. Hamstra, W. Bosch, H. Gay, and J. Michalski, “Hydrogel Spacer Prospective Multicenter Randomized Controlled Pivotal Trial: Dosimetric and Clinical Effects of Perirectal Spacer Application in Men Undergoing Prostate Image Guided Intensity Modulated Radiation Therapy,” International Journal of Radiation Oncology*Biology*Physics, vol. 92, no. 5, pp. 971–977, 2015.
• D. Y. Song, K. K. Herfarth, M. Uhl, M. J. Eble, M. Pinkawa, B. V. Triest, R. Kalisvaart, D. C. Weber, R. Miralbell, T. L. Deweese, and E. C. Ford, “A Multi-institutional Clinical Trial of Rectal Dose Reduction via Injected Polyethylene-Glycol Hydrogel During Intensity Modulated Radiation Therapy for Prostate Cancer: Analysis of Dosimetric Outcomes,” International Journal of Radiation Oncology*Biology*Physics, vol. 87, no. 1, pp. 81–87, 2013.
• G. Hatiboglu, M. Pinkawa, J.-P. Vallée, B. Hadaschik, and M. Hohenfellner, “Application technique: placement of a prostate-rectum spacer in men undergoing prostate radiation therapy,” BJU International, vol. 110, no. 11b, Dec. 2012.
• L. Racine, I. Texier, and R. Auzély-Velty, “Chitosan-based hydrogels: recent design concepts to tailor properties and functions,” Polymer International, vol. 66, no. 7, pp. 981–998, 2017.
• Y. Li, H. Meng, Y. Liu, and B. P. Lee, “Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue Engineering,” The Scientific World Journal, vol. 2015, pp. 1–10, 2015.
• J. Xu, J. Bartley, and R. Johnson, “Preparation and characterization of alginate–carrageenan hydrogel films crosslinked using a water-soluble carbodiimide (WSC),” Journal of Membrane Science, vol. 218, no. 1-2, pp. 131–146, Jan. 2003.
• C. Y. Falco, P. Falkman, J. Risbo, M. Cárdenas, and B. Medronho, “Chitosan-dextran sulfate hydrogels as a potential carrier for probiotics,” Carbohydrate Polymers, vol. 172, pp. 175–183, 2017.
• M. Dong, X. Xue, Z. Li, H. Yang, M. Sayyed, and B. Elbashir, “Preparation, shielding properties and mechanism of a novel neutron shielding material made from natural Szaibelyite resource,” Progress in Nuclear Energy, vol. 106, pp. 140–145, 2018.
• D. Yılmaz, E. Boydaş, and E. Cömert, “Determination of mass attenuation coefficients and effective atomic numbers for compounds of the 3d transition elements,” Radiation Physics and Chemistry, vol. 125, pp. 65–68, 2016.
• S. R. Manohara, S. M. Hanagodimath, and L. Gerward, “Studies on effective atomic number, electron density and kerma for some fatty acids and carbohydrates,” Physics in Medicine and Biology, vol. 53, no. 20, 2008.
• L. Shamshad, G. Rooh, P. Limkitjaroenporn, N. Srisittipokakun, W. Chaiphaksa, H. Kim, and J. Kaewkhao, “A comparative study of gadolinium based oxide and oxyfluoride glasses as low energy radiation shielding materials,” Progress in Nuclear Energy, vol. 97, pp. 53–59, 2017.
• P. Singh, T. Singh and P. Kaur, "Variation of energy absorption buildup factors with incident photon energy and penetration depth for some commonly used solvents", Annals of Nuclear Energy, vol. 35, no. 6, pp. 1093-1097, 2008.