GENETICS OF OBESITY

Year 2023, , 754 - 762, 30.12.2023

Melda Şahin , Uğur Şahin , Mustafa Calapoğlu

https://doi.org/10.17343/sdutfd.1319203

Abstract

Obesity is associated with many chronic diseases
that involve genetic and environmental factors
and are governed by their complex interactions.
Genetics is estimated to play an important role in
the predisposition to obesity and may contribute up
to 70% risk for the disease. Genetic studies have
confirmed that genes are contributory factors for
obesity. Anomalies in genes are directly responsible
for obesity-related disorders such as Bardet-Biedl
and Prader-Willi syndromes. Genetic epidemiological
approaches, particularly genome-wide association
studies, have identified numerous genes which play
important roles in human obesity. In the future, further
investigation of obesity genetics may help to develop
useful diagnostic and predictive tests for obesity
treatment. In this review, information supported by
the current literature about the genetics of obesity has
been conveyed.

Keywords

Obesity, Genetics, Gene, Heritability

OBEZİTENİN GENETİĞİ

Abstract

Obezite, genetik, çevresel faktörler ve bunların karmaşık
etkileşimleri tarafından yönetilen birçok kronik
hastalık ile ilişkilidir. Genetiğin obeziteye yatkınlıkta
önemli rol oynadığı ve hastalık riskine %70'e kadar
katkıda bulunabileceği tahmin edilmektedir. Yapılan
genetik çalışmalar, genlerin obeziteye katkıda bulunduğunu
doğrulamıştır. Genlerdeki anomaliler, Bardet-
Biedl ve Prader-Willi sendromları gibi obezite ile
ilişkili bozukluklardan doğrudan sorumludur. Genetik
epidemiyolojik yaklaşımlar, özellikle genom çapında
ilişkilendirme çalışmaları, insan obezitesinde önemli
rol oynayan çok sayıda geni tanımlamıştır. Gelecekte,
obezite genetiğinin daha fazla araştırılması,
obezite tedavisi için yararlı teşhis testleri geliştirmeye
yardımcı olabilir. Bu derleme ile obezite genetiği hakkında
güncel literatür ile desteklenmiş bilgiler aktarılmıştır.

Keywords

Obezite, Genetik, Gen, Kalıtım

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