KUPROPTOZ; BAKIR İLİŞKİLİ HÜCRE ÖLÜM YOLAĞI

Year 2023, , 764 - 770, 30.12.2023

Ebru Nur Aksu , Esin Sakallı

https://doi.org/10.17343/sdutfd.1371727

Abstract

Farklı organlarda ve metabolik süreçlerde yer alan enzimler için bir kofaktör olan bakır (Cu), hücresel ve fizyolojik insan sağlığı için gerekli olan önemli mikro besinlerden biridir. Son yıllarda hücrelerde biriken bakırın mitokondriyal solunum ve lipoik asit (LA) yolu ile ilişkili ve proteotoksik stres ile karakterize, “kuproptoz” olarak adlandırılan yeni bir programlı ölüm şekli tanımlanmıştır. Kuproptoz mekanizmasının daha iyi anlaşılmasına yönelik çalışmalar devam etmekle birlikte birçok araştırmacı da kuproptoz ve kanserin farklı özellikleri arasındaki ilişkiyi ortaya koymak amacıyla araştırmalarını sürdürmektedir. Bu derleme hücresel ve fizyolojik Cu metabolizmasına, kuproptoz mekanizmasına ve çeşitli kanser türleri ile olan ilişkisine odaklanmaktadır.

Keywords

Bakır, Kanser, Kuproptoz, Programlı Hücre Ölümü

Ethical Statement

Bu makale, insan veya hayvanlar üzerinde herhangi bir çalışma içermemektedir.

Supporting Institution

Bu araştırma, kamu, ticari veya kar amacı gütmeyen sektörlerdeki finansman kuruluşlarından herhangi bir finansal destek almamıştır.

CUPROPTOSIS; COPPER ASSOCIATED CELL DEATH PATHWAY

Abstract

Copper (Cu) is an essential micronutrient for human cellular and physiological health since it acts as a cofactor for enzymes involved in various metabolic processes throughout different organs in the body. Recently, a new type of programmed cell death, known as "cuproptosis," has been discovered and linked to mitochondrial respiration and the lipoic acid (LA) pathway. Cuproptosis is characterised by proteotoxic stress resulting from the gradual accumulation of copper in cells. Although researchers continue to study the mechanism of cuproptosis, the relationship between cuproptosis and different features of cancer is still being explored. This review examines cellular and physiological copper metabolism, the cuproptosis mechanism, and its associations with various types of cancer.

Keywords

Cancer, Copper, Cuproptosis, Programmed cell death

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