Meme Kanserinde Moleküler Alt Tiplerin Klinikopatolojik Özelliklerle İlişkisi

Year 2020, , 160 - 165, 01.06.2020

Kemal Kürşat Bozkurt , Özlem Durak İbrahim Metin Çiriş , Nilgün Kapucuoğlu , Tuba Devrim

https://doi.org/10.17343/sdutfd.605500

Abstract

Amaç: Meme
kanserinde, moleküler alt tiplerin, klinikopatolojik özellikler (tanı yaşı,
histolojik tip, histolojik derece, pT ve pN evreleri)  ile ilişkilerinin tespit edilmesi
amaçlanmıştır.

Gereç ve Yöntem: Çalışma grubu 194 kadın meme
kanseri içermekteydi. Süleyman Demirel Üniversitesi Tıp Fakültesi Tıbbi
Patoloji Anabilim Dalı arşivi taranarak 2010-2015 yılları arasında meme kanseri
tanısı verilmiş olgulara ait biyopsi ve radikal meme rezeksiyonu materyallerinin
preparatları tekrar incelendi. Olguların immünhistokimyasal ER, PgR, HER2 ve
Ki67 boyalı preparatları tekrar değerlendirilerek moleküler alt tiplendirme yapıldı.

Bulgular: Tümör
moleküler alt tipleri; %47,4 olguda Luminal A [ER ve/veya PgR(+)/HER2(-)/Ki67 ≤ %14], %25,8 olguda Luminal B [ER ve/veya PgR(+)/HER2(+) veya (-) /Ki67
> %14], %13,4 olguda HER2 overeksprese [ER(-)/PgR(-)/HER2(+)] ve %13,4 olguda ise üçlü negatif [ER(-)/PgR(-)/HER2(-)] idi. Tümör
derecesi ve aksiller lenf nodu metastazı; Luminal B, HER2 overeksprese ve üçlü
negatif tümörlerde Luminal A tümörlere göre daha yüksek izlendi. Luminal tip
tümörlerle karşılaştırıldığında, HER2 overeksprese ve üçlü negatif tümörlerde
lenfovasküler invazyon oranı anlamlı olarak daha fazla idi.

Sonuç: Heterojen
bir tümör grubu olan meme kanserlerinde evre ve diğer iyi bilinen klinikopatolojik
özelliklerin yanında moleküler alt tiplendirmenin de hasta yönetimi için
faydalı bilgiler verebileceği sonucuna varılmıştır.

Keywords

Meme, kanser, moleküler alt tip, immünhistokimya

The relationship of the molecular subtypes with the clinicopathological features in breast cancer

Abstract

Objective:
To determine the
relationship between the molecular subtypes and the clinicalopathological
features (age at the diagnosis, histological type, histological grade, pT and pN
stages) in breast cancer.

Materials and Methods: The study
population included 194 women with breast carcinoma, who were diagnosed between
2010 and 2015. The slides of the cases in the archive of the Süleyman Demirel
University Faculty of Medicine Department of Pathology were reevaluated.
Immunohistochemical ER, PgR, HER2 and Ki67 stained slides were used to perform the
molecular subtyping.

Results: Among the
cases molecular subtypes were; Luminal A [ER and/or PgR(+)/HER2(-)/Ki67 ≤
14%] in 47.4% of cases,  Luminal B [ER
and/or PgR(+)/HER2(+) or (-) /Ki67 > 14%] in 25.8% of cases, HER2
overexpressing [ER(-)/PgR(-)/HER2(+)] in 13.4% of cases, and triple
negative [ER(-)/PgR(-)/HER2(-)] in 13.4% of the cases, respectively.
Tumor grade and axillary lymph node metastasis in Luminal B, HER2
overexpressing and triple negative tumors were significantly higher than they
were in Luminal A tumors. Lymphovascular invasion rate was significantly higher
in HER2 overexpressing and triple negative tumors compared to Luminal type
tumors.

Conclusions: It was concluded that the molecular subtyping of the breast carcinoma, which
is a heterogeneous tumor group, can give important information for the
management of the cases along with the stage and other well-known clinicopathological
features.

Keywords

Breast, cancer, molecular subtype, immunohistochemistry

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