Abstract
SüleymanDemirel Üniversitesi
TIP FAKÜLTESİ DERGİSİ: 1999 Eylül; 6(3)
Administration ofAnticonvulsant Drugs by the Intraperitoneal Route
Ruşen Dündaröz, Tuncer Değim, Ali Sızlan, Mehmet Yaşar, Metin Denli, Uğur Tamer
Abstract
Status epilepticus or seizures cause serious brain damages and irreversible cerebral injury if it prolongs and it is essential to terminate seizure rapidly. Antiepileptic drugs can be introduced to the patients intravenously (IV), hut it is almost impossible to achieve IV access during the seizure. Intraperitoneal (IP) route can be accessible but, IP route of administration of antiepileptic drugs has not been used so far. Therefore the possibility of IP administration of anti epileptic drugs was investigated in this study. Antiepileptic drug (diazepam, phenytoin or phenobarbital) was introduced rabbits and dogs by IV and IP routes and blood samples were collected by the time during the period of 60 to 120 minutes. Blood samples vere analyzed and drug contents -were determined. The plasma profiles of antiepileptic drugs were obtained and compared. The plasma profiles of antiepileptic drugs were found to be low when they were administered by IP route. It was concluded that the IP administration of antiepileptic drugs could not be an alternative route to IV administration.
Key Words: Convulsion, anticonvulsant drugs, Intraperitoneal route
Antikonvülzon İlaçların İntraperitonal Yoldan Verilmeleri
Özet
Epilepsi veya epilepsi nöbeti ciddi beyin hasarlarına neden olabilir, ve eğer fazla uzun sürerse geri dönüşsüz beyin harabiyetine neden olabilir, bu nedenle nöbetin süratle durdurulması oldukça önemlidir. Antiepileptik ilaçlar hastalara intravenöz(IV) yolla verilebilir ancak nöbetler esnasında hastaya IV ulaşım hemen hemen imkansızdır ancak intraperitonal(IP)yol ile ilaç verilmesi mümkündür.
Keywords
Details
| Primary Language | English |
|---|---|
| Journal Section | Research Articles |
| Authors | |
| Publication Date | March 12, 2009 |
| Submission Date | March 12, 2009 |
| Published in Issue | Year 1999 Volume: 6 Issue: 3 |
Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi/Medical Journal of Süleyman Demirel University is licensed under Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International.