Herbisidlere maruz kalma ile koroner arter ektazisi arasındaki ilişki

Year 2007, Volume: 14 Issue: 3, 13 - 16, 06.05.2009

Mehmet Özaydın , Halil Kahraman Ercan Varol Süleyman Aslan Abdullah Doğan Ahmet Altınbaş

Abstract

Süleyman Demirel Üniversitesi
TIP FAKÜLTESİ DERGİSİ: 2007 Eylül; 14(3)



Herbisidlere maruz kalma ile koroner arter ektazisi arasındaki ilişki



Mehmet Özaydın*, Halil Kahraman*, Ercan Varol**, Süleyman M. Aslan*, Abdullah Doğan*, Ahmet Altınbaş*



*Süleyman Demirel Üniversitesi, Kardiyoloji AD, Isparta,

**Isparta Devlet Hastanesi, Isparta



Özet



Anjiyografik olarak, epikardiyal koroner arterlerde obstrüktif lezyon olmaksızın normal luminal çaptan 1.5-2 kat arasında genişleme koroner ektazi, 2 kattan fazla genişleme ise koroner anevrizma olarak tanımlanmaktadır. Çiftçilerin yaygın olarak kullandıkları herbisidlere uzun süre maruz kalınması asetilkolin konsantrasyonunu artırarak nitrik oksit üzerinden vasküler düz kaslarda relaksasyona neden olmaktadır. Fakat kronik relaksasyonun koroner arter ektazisine neden olup olmadığı bilinmemektedir. Çalışmamızın amacı, izole koroner arter ektazisi olan olgularda kontrol grubuna göre herbiside maruz kalma sıklığını araştırmaktı.



Anahtar kelimeler: Koroner arter ektazisi, herbisid



Abstract



The relationship between exposure to the herbicides and coronary artery ectasia



The dilatation of the epicardial coronary arteries 1.5-2 times that of normal adjacent segment is called coronary ectasia and >2 times that of normal adjacent segment is called coronary aneurysm. Longterm exposure to the herbicides, which are frequently used by farmers, cause relaxation in the vascular smooth muscles via nitric oxide by increasing acetilcholin concentrations. However, it is unknown whether chronic exposure to these substances causes coronary ectasia. Therefore, the aim of the present study was to compare the rate of exposure to these herbicides in patients with coronary ectasia and control group.



Key words: Coronary artery ectasia, herbicide

Keywords

Koroner arter ektazisi , herbisid

References

• Hartnell GG, Parnell BM, Pridie RB. Coronary artery ectasia, its prevalence and clinical significance in 4993 patients. Br Heart J 1985; 54: 392-95.
• Krüger D, Stierle U, Herrmann G, Simon R, Sheikhzadeh A. Exercise-Induced myocardial ischemia in isolated coronary artery ectasias and aneurysms (“Dilate coronaropathy”). Am J Cardiol 1999; 34: 461-70.
• Sayýn T, Döven O, Berkalp B, Akyürek Ö, Güleç S, Oral D. Exercise-induced myocardial ischemia in patients with coronary artery ectasia without obstructive coronary artery disease. Int J of Cardiol 2001; 78: 143-49.
• Markis JE, Joffe CD, Cohn PF, Feen DJ, Herman MV, Gorlin R. Clinical significance of coronary artery ectasia. Am J Cardiol 1976; 37: 217-22.
• Maehara A, Mintz GS, Ahmed JM, Fuchs S, Castagna MT, Pichard AD, Datler LF, Waksman R, Suddath WO, Kent KM, Weissman NJ. An ýntravascular ultrasound classification of angiographic coronary artery aneurysms. Am J Cardiol 2001; 88: 365-70.
• Sorrel VL, Davis MJ, Bove AA. Origins of coronary artery ectasia. Lancet 1996; 347: 136- 37.
• Kahraman H, Ozaydin M, Varol E, Aslan SM, Dogan A, Altinbas A, Demir M, Gedikli O, Acar G, Ergene O. The diameters of the aorta and its major branches in patients with isolated coronary artery ectasia. Tex Heart Inst J. 2006;33(4):463- 8.
• Williams MJA, Stewart RAH. Coronary artery ectasia, local pathology or diffuse disease. Cathet Cardiovasc Diagn 1994; 33: 116-19.
• Kajinami K, Kasashimas S, Oda Y, Koizumi J, Katsuda S, Mabuchi H. Coronary ectasia in familial hypercholesterolemia:histopathologic study regarding matrix metalloproteinases. Mod Pathol 1999; 12: 1174-80.