Salivary gland masses: analysis of 158 cases

Year 2011, Volume: 18 Issue: 3, 82 - 85, 30.09.2011

Banu Atalay

Abstract

Objective : To evaluate histopathological results with retrospective analysis of patients who came to our clinic with a salivary gland pathology. Material and methods: 158 patients (96 men, 62 women; mean age: 44.3; distribution 18-77) with parotid, submandibular and sublingual salivary gland pathology compliants (mass,pain) who came to our clinic between January 2000 and June 2009 had been included in this study. Data of salivary glands in which mass located and results of postoperative histopathological examinations were assessed. Results: 130 patients (82%) were operated because of parotid pathology , 26 of them(16%) because of submandibular gland pathology and 2 of them(1%) because of sublingual pathology.Histopathological results were 14(8,9%) malignant, 123(77.8%) benign and 21(13.3%) nonneoplastic. Of those who had been operated because of a parotid gland pathology 115(88.5%) were benign, 12(9.1%) malignant and 3(2.2%) nonneoplastic. Our submandibular gland results were 7(26.9%) benign, 18(69.2%) nonneoplastic and 1(3.9%) malignant. One of two cases who had been operated because of sublingual gland pathology was malignant and the other one was benign. Conclusion: Because of histopathological diversity; provisional diagnosis of salivary gland mass is important. Radiological techniques such as ultrasonography, computerized tomography and magnetic resonance and fine needle aspiration biopsi help us seperation of benign and malign histopathology. After diagnosing the salivary gland mass, the most appropriate surgical technique should be applied to the patient. 

Keywords

Salivary glands, mass, histopathology

TÜKÜRÜK BEZİ KİTLELERİNDE HİSTOPATOLOJİK ÇEŞİTLİLİK:158 OLGUNUN ANALİZİ

Abstract

Amaç: Tükürük bezi patolojisi nedeniyle kliniğimize başvuran hastaları retrospektif olarak inceleyerek; histopatolojik sonuçlarını değerlendirmek.
Hastalar ve yöntemler: Ocak 2000 ile Haziran 2009 tarihleri arasında parotis, submandibuler ve sublingual tükürük bezi patolojisi (şişlik, ağrı) şikayetleri ile kliniğimize başvuran 158 hasta (96 erkek, 62 kadın; ortalama yaş 44.3 ; dağılım 18-77) çalışmaya dahil edildi.Kitlelerin yerleştiği tükürük bezi ve postoperatif histopatolojik sonucları değerlendirildi..
Bulgular: Olgularımızın 130'u (% 82) parotis, 26'sı (% 16) submandibuler ve 2'si (% 1) sublingual tükürük bezi patolojisi nedeniyle opere edildi. Ameliyat sonrası vakalarımızın histopatolojik sonuçları toplamda 14'ü (% 8.8) habis , 123'ü (% 77.8) selim ve 21'i(% 13.3) ise nonneoplastikti. Bunlardan parotis bezi patolojisi ile opere olan hastaların 116'sı (% 88.5) selim, 12'si (% 9.1) malign, 3'ü (% 2.2) nonneoplastik karakterdeydi. Submandibuler bezde olgularımız arasında 7 (% 26.9 ) selim, 18 (% 69.2) nonneoplastik histopatolojik sonuç var iken ; 1(% 3.9) vakada malign patoloji mevcuttu. Sublingual bez patoloji nedeniyle opere edilen 2 olgumuzun 1'i selim 1'i habisti.
Sonuç: Histopatolojik olarak tükürük bezi tümörlerinin çeşitliliği, varyasyonları ve preoperatif tanı zorluğu, tükürük bezinde kitle ile gelen hastalara uygulanabilecek standart bir cerrahi protokolünü zorlaştırmaktadır.

Keywords

Tükrük bezleri, kitle, histopatoloji

References

• Yaðýz C, Karaman E. Tükürük bezlerinin selim tümörleri. Türkiye Klinikleri.J Surg Med Sci (Özel sayýlar) Kulak Burun Boðaz Dergisi 2007;3(36):22-6.
• Spiro IJ, Wang CC, Montgomery WW. Carcinoma of the parotid gland. Analysis of treatment results and patterns of failure after combined surgery and radiation therapy. Cancer 1993; 71(9): 2699-705. PMID:8467451
• Kane WJ, McCaffrey TV, Olsen KD, Lewis JE. Primary parotid malignancies. A clinical and pathologic review. Arch Otolaryngol Head Neck Surg 1991; 117(3): 307- 15. PMID:1998571
• Armstrong JG, Harrison LB, Thaler HT et al. The indications for elective treatment of the neck in cancer of the major salivary glands. Cancer 1992; 69(3): 615- 9. PMID:1730113
• Rice DH. Nonneoplastic diseases of the salivary glands. Otolaryngology’de. Ed. Paparella MM. 3th ed. Volume 3.Philadelphia, Saunders Comp 1993; 475-86.
• Cuhruk Ç, Yýlmaz O. Parotis bezi kitlelerinde taný yöntemleri. Kulak Burun Boðaz ve Baþ Boyun Cerrahisi Dergisi 1993; 1(3): 155-8
• Seifert G, Miehlke A, Haubrich J ve ark. Diseases of the Salivary Glands. Stuttgart, Georg Thieme Verlag, 1986; 171-82.
• Duck SW, McConnel FM. Malignant degeneration of pleomorphic adenoma-clinical implications. Am J Otolaryngol. 1993;14(3):175-8. PMID:8393306
• Hicks J, Flaitz C. Mucoepidermoid carcinoma of salivary glands in children and adolescents: assessment of proliferation markers. Oral Oncol 2000; 36(5): 454- 60. PMID:10964053
• Seifert G, Sobin LH. The World Health Organization's Histological Classification of salivary gland tumors. A commentary on the second edition. Cancer 1992; 70(2): 379-85. PMID:1617588
• Matsuba HM, Mauney M, Simpson JR, Thawley SE, Pikul FJ. Adenocarcinomas of major and minor gland origin:a histopathologic review of treatment patterns.Laryngoscope 1988; 98(7): 784-8. PMID:3386387
• Koka VN, Tiwari RM, Van der Waal I ve ark. Adenoid cystic carcinoma of salivary glands: clinicopathological survey of 51 patients. J Laryngol Otol 1989; 103(7): 675-9. PMID:2547888
• Yazýcý MF, Devge KC, Yücel Z, Erdibil H. 122 parotis tümöründe tedavi yöntemlerimiz ve sonuçlarý. Türk ORL Arþivi 1996; 34(1): 19-22.
• Hodgkinson DJ. Woods JE. The Influence of Facial Nerve Sacrifice in Surgery Of Malignant Parotid Tumors. J Surg Oncol 1976; 8: 425-33.
• Ball A, Thomas JM. Malignant Tumours of The Major Salivary Glands. In: Normon JED. Mcgurk (Eds). Salivary Glands Diseases, Disorders And Surgery. Mosby-Wolfe. Barcelona. 1995; 173-196.
• Buchman C, Stringer SP, Mendenhall WM, Parsons JT, Jordon JR, Cassisi NJ. Pleomorfic adenoma: effect of tumor spill and inadequate resection on tumor recurrence. Laryngoscope 1994;104(110): 1231-4. PMID:7934593
• Altar B, Özkul MD, Tatar A, Uður O, Kaptaner S, Ceylan S. Parotis kitlelerinde cerrahi prensipleri. Türk ORL Arþivi 1995; 33(2):85-7.
• Akbas Y, Tuna EU, Demireller A, Ozcan H, Ekinci C. Ultrasonography guided fine needle aspiration biopsy of parotid gland masses. Kulak Burun Bogaz Ihtis Derg. 2004;13:(1-2):15-8. PMID: 16027486
• Kechagias N, Ntomouchtsis A, Valeri R, Patrikidou A, Kitikidou K, Xirou P et al. Fine-needle aspiration cytology of salivary gland tumours: a 10-year retrospective analysis. Oral Maxillofac Surg. 2011 Sep 6. [Epub ahead of print] PMID: 21894513
• Lincoln GL Tan, Mark LC Khoo. Accuracy of Fine
• Needle Aspiration Cytology and Frozen Section Histopathology for Lesions of the Major Salivary Glands. Ann Acad Med Singapore 2006;35:242-8. PMID:16710494