CASTLEMAN HASTALIĞI: İKİ OLGU SUNUMU VE LİTERATÜRÜN GÖZDEN GEÇİRİLMESİ

Yıl 2012, Cilt: 19 Sayı: 4, 151 - 155, 30.12.2012

Mustafa Yıldız Mustafa Yıldırım Cem Parlak Nurullah Bülbüller Ramazan Eryılmaz Cem Sezer Müjgan Yaz Dinç Süren Çetin Kaya

Öz

Castleman hastalığı (CH) anjiofoliküler displazi olarak da adlandırılan lenfoproliferatif bir hastalıktır. Multisentrik ve unisentrik olmak üzere farklı prognozlara sahip iki farklı hastalığı içermektedir.
CH lenf nodunun yapısını koruyarak büyümesi ile karakterize bir hastalıktır. Hyalin vasküler, plazma hücreli ve mikst tip olmak üzere üç temel varyant tanımlanmıştır.
CH'nin patogenezine yönelik çalışmalar daha çok multisentrik CH (MCH) HHV 8 (+) hastalığa yönelik yapılmıştır. Unisentrik CH (UCH) ve HHV8 (-) MCH' lı hastalarda patogenez net değildir.
CH malign seyirli lezyonlarla karışabilmektedir. Bu yazıda biri unisentrik hyalin vasküler varyant ve diğeri multisentrik plazma hücreli varyantlı iki olgumuz güncel literatür ışığında tartışılmıştır.

Anahtar Kelimeler

Castleman hastalýðý, Olgu sunumu, Literatür derlemesi

Kaynakça

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