2. TRİMESTER GENETİK TARAMA AMNİYOSENTEZ 1586 OLGUNUN DEĞERLENDİRİLMESİ

Yıl 2012, Cilt: 19 Sayı: 4, 144 - 147, 30.12.2012

Önder Kaplan Mehmet Güney Murat Yüksel

Öz

ÖZET
Amaç: Amniyosentez girişimlerindeki endikasyonların dağılımı, yaşa göre oranları, girişim işlemleri, hücre kültür sonuçları incelenmektedir.
Materyal ve method: Şubat 2003 - Aralık 2011 tarihleri arasında Süleyman Demirel Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum kliniğinde yüksek riskli gebeliklerde karyotip amaçlı yapılan amniyosentez sonuçları retrospektif olarak değerlendirilmiştir.
Bulgular: 1586 olgu incelendi. Hastaların yaş aralığı 19–24 yaş % 8 (132/1586), 25–30 yaş % 13 (217/1586), 31–35 yaş % 24 (389/1586), 36–40 yaş % 36 (574/1586), 41–44 yaş % 17 (274/1586) oranında saptandı. Amniyosentezin 15–22 haftalar (17,2±1,4) arasında yapıldığı görüldü. Kromozomal anomali % 3,65 (58/1586) hastada görüldü. Trizomi 21 (Down sendromu) % 1,1 (18/1586) olarak belirlendi. Down sendromu saptanan hastalar 32, 43 yaşları arasında idi. Amniyosentez sonrasında gebelik kaybı % 0,6 (11/1586) olarak saptandı.
Sonuçlar: Anomali saptanan olgulara genetik danışmanlık hizmeti verilmiştir.
Anahtar Kelimeler: Amniyosentez, Genetik, Kromozomal Anomali, Down Sendromu, Genetik Danışmanlık

ABSTRACT
Objective: The distribution of indications for amniocentesis attempts, rates by age, intervention methods, cell culture results are analyzed.
Material and Methods: Amniocentesis performed for karyotyping in high risk pregnancies in department of Obstetrics and Gynecology, Süleyman Demirel University between 2003 and 2011 are investigated retrospectively.
Results: 1586 cases are evaluated. Age of 19–24 8 % (132/1586), age of 25–30 13 % (217/1586), age of 31–35 % 24 (389/1586), age of 36–40 % 36 (574/1586), age of 41–44 % 17 (274/1586) was determined. 15-22 weeks of amniocentesis (17.2 ± 1.4) were made between. 3.65 % of chromosomal abnormalities (58/1586) of the patients had. Trisomy 21 (Down Syndrome) 1.1 % (18/1586) was determined. The patients with Down syndrome, 32 and 43years of age. 0,6 % (11/1586) pregnancy loss after amniocentesis
Conclusion: Genetic counseling is provided for all cases.
Key Words: Amniocentesis, Genetic, Chromosomal Abnormality, Genetic Counseling

Anahtar Kelimeler

Amniyosentez, Genetik, Kromozomal Anomali, Down Sendromu, Genetik Danýþmanlýk

Kaynakça

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