The relation of vitamin D with immune system, skin and cancer.

Öz

The relation of vitamin D with immune system, skin and cancer.In humans, approximately 95% of the total requirement for vitamin D is synthesized in the skin by the effectsof sunlight. The active vitamin D synthesis from 25 (OH) D takes place via the 1-alpha hydroxylase enzymeboth in renal and non-renal tissues. The effect of vitamin D on the receptor level is through active vitaminD. Vitamin D receptors are shown in more than 30 tissues. Non-classical effects of vitamin D are groupedunder three main headings: Regulation of hormone secretion, regulation of immune function, regulation ofcell proliferation and differentiation. The relationship immune system, skin diseases cancer and vitamin Dis the most widely researched topics

Anahtar Kelimeler

• Vitamin D
• immune system
• skin
• cancer

D VİTAMİNİNİN İMMÜN SİSTEM, DERİ VE KANSER İLE İLİŞKİSİ

Öz

İnsanlarda D vitamini ihtiyacının yaklaşık % 95'i güneş ışınlarının etkisiyle deride sentezlenmektedir. Böbrek dışı dokularda da 1-alfa hidroksilaz enzimi aracılığıyla aktif vitamin D sentezi gerçekleşmektedir. D vitamininin reseptör düzeyindeki etkisi aktif vitamin D sayesinde olur. Otuzdan fazla dokuda vitamin D reseptörleri gösterilmiştir. Vitamin D'nin iskelet sistemi dışındaki etkileri 3 ana başlık altında toplanmaktadır: Hormon sekresyonunun regülasyonu, immün fonksiyonların regülasyonu, hücre proliferasyon ve farklılaşmasının düzenlenmesi. İmmun sistem, cilt hastalıkları, kanser vitamin D ile ilişkisi en çok araştırılan konular arasındadır. Anahtar Kelimeler: D vitamini; kemik dışı etkiler; immün sistem; deri; kanser SUMMARY In humans, approximately 95% of the total requirement for vitamin D is synthesized in the skin by the effects of sunlight. The active vitamin D synthesis from 25 (OH) D takes place via the 1-alpha hydroxylase enzyme both in renal and non-renal tissues. The effect of vitamin D on the receptor level is through active vitamin D. Vitamin D receptors are shown in more than 30 tissues. Non-classical effects of vitamin D are grouped under three main headings: Regulation of hormone secretion, regulation of immune function, regulation of cell proliferation and differentiation. The relationship immune system, skin diseases and cancer between vitamin D is the most widely researched topics. Key words: Vitamin D; nonskeletal effects; immune system; skin; cancer

Anahtar Kelimeler

• D vitamini
• immün sistem
• deri
• kanser

Kaynakça

1. 1 . Bikle D. Nonclassic Actions of Vitamin D. J Clin Endocrinol Metab 2009; 94(1): 26–34
2. 2 . Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, et al. The Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement. Endocrine Reviews 2012; 33(3): 456–492
3. 3 . Özkan B, Döneray H. D vitamininin iskelet sistemi dýþý etkileri. Çocuk Saðlýðý ve Hastalýklarý Dergisi 2011; 54: 99-119
4. 4 . Chen S, Sims GP, Chen XX, Gu YY, Chen S, Lipsky PE. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol 2007; 179: 1634–1647
5. 5 . Penna G, Adorini L. 1a,25-Dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation. J Immunol 2000; 164: 2405–2411
6. 6 . Adorini L. Intervention in autoimmunity: the potential of vitamin D receptor agonists. Cell Immunol 2005; 233: 115–124
7. 7 . Deluca HF, Cantorna MT. Vitamin D: its role and uses in immunology. FASEB J 2001; 15: 2579–2585
8. 8 . Ponsonby AL, McMichael A, van der Mei I. Ultraviolet radiation and autoimmune disease: insights from epidemiological research. Toxicology 2002; 181–182: 71–78

9. 9 . Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001; 358: 1500–1503
10. 1 0 . Bikle DD, Oda Y, Xie Z. Calcium and 1,25(OH)2D: interacting drivers of epidermal differentiation. J Steroid Biochem Mol Biol 2004; 89–90: 355–360
11. 11 . Skorija K, Cox M, Sisk JM, Dowd DR, MacDonald PN, Thompson CC, et al. Ligand-independent actions of the vitamin D receptor maintain hair follicle homeostasis. Mol Endocrinol 2005; 19: 855–862
12. 1 2 . Xie Z, Komuves L, Yu QC, Elalieh H, Ng DC, Leary C, et al. Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol 2002; 118: 11–16
13. 1 3 . Ozkan B. Nutritional rickets. J Clin Res Pediatr Endocrinol 2010; 4: 137-143.
14. 1 4 . Holick MF. Vitamin D: extraskeletal health. Endocrinol Metab Clin North Am 2010; 39: 381-400.
15. 1 5 . Teichert AE, Elalieh H, Elias PM, Welsh J, Bikle DD. Overexpression of hedgehog signaling is associated with epidermal tumor formation in vitamin D receptor null mice. J Invest Dermatol 2011; 131: 2289–2297
16. 1 6 . Ellison TI, Smith MK, Gilliam AC, MacDonald PN. Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis. J Invest Dermatol 2008; 128: 2508–2517
17. 1 7 . Zinser GM, Sundberg JP, Welsh J. Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis. Carcinogenesis 2002; 23: 2103–2109
18. 1 8 . Manson JE, Mayne ST, Clinton SK. Vitamin D and prevention of cancer—ready for prime time? (perspective). N Engl J Med 2011; 364: 1385–1387
19. 1 9 . Krishnan AV, Feldman D. Mechanisms of the anticancer and anti-inflammatory actions of vitamin D. Annu Rev Pharmacol Toxicol 2011; 51: 311–336
20. 2 0 . Deeb KK, Trump DL, Johnson CS. Vitamin D signaling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 2007; 7: 684–700
21. 2 1 .Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the
22. Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 2011; 96: 53–58
23. 2 2 . Trivedi DP, Doll R, Khaw KT. Effect of four-monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003; 326: 469
24. 2 3 . Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 2007; 85: 1586–1591
25. 2 4 . Gross C, Stamey T, Hancock S, Feldman D. Treatment of early recurrent prostate cancer with 1,25- dihydroxyvitamin D3 (calcitriol). J Urol 1998; 159: 2035–2039; discussion 2039–2040
26. 2 5 . Rossi M, McLaughlin JK, Lagiou P, Bosetti C, Talamini R, Lipworth L, et al. Vitamin D intake and breast cancer risk: a case-control study in Italy. Ann Oncol 2009; 20: 374–378
27. 2 6 . Anderson LN, Cotterchio M, Vieth R, Knight JA. Vitamin D and calcium intakes and breast cancer risk in pre- and postmenopausal women. Am J Clin Nutr 2010; 91: 1699–1707
28. 2 7 . Tangpricha V, Spina C, Yao M, Chen TC, Wolfe MM, Holick MF. Vitamin D deficiency enhances the growth of MC-26 colon cancer xenografts in Balb/c mice. J Nutr 2005; 135: 2350–2354
29. 2 8 . Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S. Plasma vitamin D and risk of colorectal cancer: the Japan Public Health Center-Based Prospective Study. Br J Cancer 2007; 97: 446-451
30. 2 9 . Chung M, Lee J, Terasawa T, Lau J, Trikalinos TA. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta- analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2011; 155: 827–838
31. 3 0 . Washington MN, Weigel NL. 1a,25-Dihydroxyvitamin D3 inhibits growth of VCaP prostate cancer cells despite inducing the growth-promoting TMPRSS2:ERG gene fusion. Endocrinology 2010; 151: 1409–1417
32. 3 1 . Helzlsouer KJ, VDPP Steering Committee. Overview of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol 2010; 172: 4–9