Yıl 2018, Cilt 25 , Sayı 4, Sayfalar 487 - 497 2018-12-01

Biological and Functional Properties of Possible Prebiotic Properties of Exopolysaccharides (EPSs) from Probiotics
Probiyotik Kaynaklı, Muhtemel Prebiyotik Özelliğe Sahip Ekzopolisakkarit (EPS)’ lerin Biyolojik ve Fonksiyonel Özellikleri

Ümmügülsüm TÜKENMEZ [1] , Belma ASLIM [2]


Nowadays, cancer is one of the most important health problems and is one of the diseases that causes the most deaths in the world. Existing anti-cancer drugs used in cancer treatment show toxicity dose dependent manner and cause strong side effects (infection, hair loss, fatigue, lip sores, nausea, vomiting, diarrhea and bloody feces). Therefore, there is a need to develop anti-cancer agents that are effective and less toxic in the cancer treatment. Exopolysaccharides (EPSs) obtained from safe and natural sources, such as lactic acid bacteria (LAB), are thought to be a good alternative to synthetic anti-cancer agents. The usefulness of the various EPSs is due to the fact that the EPS is dependent on the monosaccharide composition, the ties of the bonds, the branching degrees and the molecular weight, this review contains information on the structure and biological activity of EPSs and the mechanism of anti-cancer action of EPSs.


Kanser, günümüzün en önemli sağlık sorunlarından birisidir ve dünyada en çok ölüme neden olan hastalıklardan biridir. Kanser tedavisinde kullanılan mevcut anti-kanser ilaçlar doza bağlı olarak toksisite göstermekte ve güçlü yan etkilere (enfeksiyon, saç dökülmesi, yorgunluk, dudak yaraları, mide bulantısı, kusma, diyare ve kanlı dışkılar) neden olmaktadır.  Dolayısıyla kanserin tedavisinde etkili ve daha az toksik olan anti-kaser ajanların geliştirilmesine ihtiyaç duyulmaktadır.  Laktik asit bakterileri (LAB) gibi güvenilir ve doğal kaynaklardan elde edilen ekzopolisakkarit (EPS)’lerin, sentetik anti-kanser ajanlarına göre iyi bir alternatif olabileceği düşünülmektedir. Çeşitli EPS’lerin yararlılığı EPS’nin monosakkarit kompozisyonuna, bağların türüne, dallanma derecelerine ve molekül ağırlığına bağlı olduğu için bu derleme EPS’lerin yapısı ve biyolojik aktivitesi ve EPS’lerin anti-kanser etkileri ile ilgili bilgiler içermektedir.

 


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Birincil Dil tr
Konular Tıp
Bölüm Derlemeler
Yazarlar

Yazar: Ümmügülsüm TÜKENMEZ
Kurum: GAZİ ÜNİVERSİTESİ
Ülke: Turkey


Yazar: Belma ASLIM
Kurum: GAZİ ÜNİVERSİTESİ
Ülke: Turkey


Tarihler

Başvuru Tarihi : 12 Ekim 2017
Kabul Tarihi : 15 Şubat 2018
Yayımlanma Tarihi : 1 Aralık 2018

Vancouver Tükenmez Ü , Aslım B . Probiyotik Kaynaklı, Muhtemel Prebiyotik Özelliğe Sahip Ekzopolisakkarit (EPS)’ lerin Biyolojik ve Fonksiyonel Özellikleri. SDÜ Tıp Fakültesi Dergisi. 2018; 25(4): 487-497.