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Probiyotik Kaynaklı, Muhtemel Prebiyotik Özelliğe Sahip Ekzopolisakkarit (EPS)’ lerin Biyolojik ve Fonksiyonel Özellikleri

Yıl 2018, Cilt: 25 Sayı: 4, 487 - 497, 01.12.2018
https://doi.org/10.17343/sdutfd.343111

Öz



Kanser, günümüzün en önemli sağlık
sorunlarından birisidir ve dünyada en çok ölüme neden olan hastalıklardan
biridir. Kanser tedavisinde kullanılan mevcut anti-kanser ilaçlar doza bağlı
olarak toksisite göstermekte ve güçlü yan etkilere (enfeksiyon, saç dökülmesi,
yorgunluk, dudak yaraları, mide bulantısı, kusma, diyare ve kanlı dışkılar)
neden olmaktadır.  Dolayısıyla kanserin
tedavisinde etkili ve daha az toksik olan anti-kaser ajanların geliştirilmesine
ihtiyaç duyulmaktadır.  Laktik asit
bakterileri (LAB) gibi güvenilir ve doğal kaynaklardan elde edilen ekzopolisakkarit
(EPS)’lerin, sentetik anti-kanser ajanlarına göre iyi bir alternatif
olabileceği düşünülmektedir. Çeşitli
EPS’lerin yararlılığı EPS’nin monosakkarit kompozisyonuna, bağların türüne,
dallanma derecelerine ve molekül ağırlığına bağlı olduğu için bu derleme EPS’lerin
yapısı ve biyolojik aktivitesi ve EPS’lerin anti-kanser etkileri ile ilgili
bilgiler içermektedir.



 




Kaynakça

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  • 2. Kanchana A, Balakrishna M. Anti-cancer effect of saponins isolated from solanum trilobatum leaf extract and induction of apoptosis in human larynx cancer cell lines. Int J Pharm Pharm Sci 2011; 3: 356-364.
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  • 6. Wagner AD, Grothe W, Haerting J, Kleber G, Grothey A, Fleig WE. Chemotherapy in advanced gastric cancer: A systematic review and meta-analysis based on aggregate data. J Clin Oncol 2006; 24, 2903−2909.
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  • 26. Kristo E, Miao Z, Corredig M. The role of exopolysaccharides produced by Lactococcus lactis subsp. cremoris in structure formation and recovery of acid milk gels. Int Dairy J 2011; 21: 656–662.
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Biological and Functional Properties of Possible Prebiotic Properties of Exopolysaccharides (EPSs) from Probiotics

Yıl 2018, Cilt: 25 Sayı: 4, 487 - 497, 01.12.2018
https://doi.org/10.17343/sdutfd.343111

Öz



Nowadays, cancer is one of the most
important health problems and is one of the diseases that causes the most
deaths in the world. Existing anti-cancer drugs used in cancer treatment show
toxicity dose dependent manner and cause strong side effects (infection, hair
loss, fatigue, lip sores, nausea, vomiting, diarrhea and bloody feces).
Therefore, there is a need to develop anti-cancer agents
that are effective and less toxic in the cancer treatment. Exopolysaccharides (EPSs)
obtained from safe and natural sources, such as lactic acid bacteria (LAB), are
thought to be a good alternative to synthetic anti-cancer agents. The
usefulness of the various EPSs is due to the fact that the EPS is dependent on
the monosaccharide composition, the ties of the bonds, the branching degrees
and the molecular weight, this review contains information on the structure and
biological activity of EPSs and the mechanism of anti-cancer action of EPSs.




Kaynakça

  • 1. Zandi K, Tajbakhsh S, Nabipour I, Rastian Z, Yousefi F, Sharafian S, Sartavi K. In vitro antitumor activity of Gracilaria corticata (a red alga) against jurkat and molt-4 human cancer cell lines. Afr J Biotechnol 2010; 9: 6787-6790.
  • 2. Kanchana A, Balakrishna M. Anti-cancer effect of saponins isolated from solanum trilobatum leaf extract and induction of apoptosis in human larynx cancer cell lines. Int J Pharm Pharm Sci 2011; 3: 356-364.
  • 3. Hemamalini K, Soujanya GL, Bhargav A, Vasireddy U. In-vivo anticancer activity of Tabebuia rosea (bertol) dc. leaves on Dalton’s ascetic lymphoma in mice. Int J Pharm Sci Res 2012; 3: 4496-4502.
  • 4. Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, Thun M. Cancer stat, 2006. CA Cancer J Clin 2006; 56: 106-130.
  • 5. Adamsen L, Quist M, Midtgaard J, Andersen C, Moller T, Knutsen L, Tveteras A, Rorth M. The effect of a multidimensional exercise intervention on physical capacity, well-being and quality of life in cancer patients undergoing chemotherapy. Support Care Cancer 2006, 14, 116−127.
  • 6. Wagner AD, Grothe W, Haerting J, Kleber G, Grothey A, Fleig WE. Chemotherapy in advanced gastric cancer: A systematic review and meta-analysis based on aggregate data. J Clin Oncol 2006; 24, 2903−2909.
  • 7. Abd El Ghany K, Hamouda R, Abd Elhafez E, Mahrous H, Salem-Bekhit M, Hamza HA. A potential role of Lactobacillus acidophilus LA1 and its exopolysaccharides on cancer cells in male albino mice. Biotechnol Biotechnol Equip 2015; 29 (5): 977-983.
  • 8. Li W, Xia X, Tang W, Ji J, Rui X, Chen X, Jiang M, Zhou J, Zhang Q, Dong M. Structural characterization and anticancer activity of cell-bound exopolysaccharide from Lactobacillus helveticus MB2-1. J Agric Food Chem 2015; 63 (13): 3454-3463.
  • 9. Salminen S, Bouley C, Boutron-Ruaultetal MC. Functional food science and gastrointestinal physiology and function. Br J Nutr 1998; 80 (1): 147–171.
  • 10. FAO/WHO. 2001. Reporton Joint FAO/WHO Expert Consultationon Evaluation of Health and Nutritional Properties of Probiotics in Food Including Powder Milk with Live Lactic Acid Bacteria.
  • 11. Hussein MDM, Ghaly MF, Osman MY, Al Shimaa GS, Helal MM. Production and prebiotic activity of exopolysaccharides derived from some probiotics. Egypt Pharmaceut J 2015; 14 (1): 1.
  • 12. Surayot U, Wang J, Seesuriyachan P, Kuntiya A, Tabarsa M, Lee, Y., Kim, JK., Park, W., You, S. Exopolysaccharides from lactic acid bacteria: structural analysis, molecular weight effect on immunomodulation. Int J Biol Macromol 2014; 68: 233-240.
  • 13. Van Calsteren, MR, Pau-Roblot C, Bégin A, Roy D. Structure determination of the exopolysaccharide produced by Lactobacillus rhamnosus strains RW-9595M and R. Biochemical Journal 2002; 363: 7-17.
  • 14. Doleyres Y, Schaub L, a Lacroix C. Comparison of the functionality of exopolysaccharides produced in situ or added as bioingredients on yogurt properties. J Dairy Sci 2005; 88: 4146-4156.
  • 15. Kim Y, Oh S, Yun HS, Kim SH. Cell‐bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells. Lett Appl Microbiol 2010; 51 (2): 123-130.
  • 16. Looijesteijn PJ, Trapet L, de Vries E, Abee T, Hugenholtz J. Physiological function of exopolysaccharides produced by Lactococcus lactis. Int J Food Microbiol 2001; 64: 71–80.
  • 17. Whitfield C, Valvano MA. Biosynthesis and expression of cell-surfaces polysaccharides in gram-negative bacteria. Adv Microb Physiol 1993; 35: 135–146.
  • 18. Freitas F, Alves VD, Reis MA. Advances in bacterial exopolysaccharides: from production to biotechnological applications. Trends Biotechnol 2011; 29: 388-398.
  • 19. Patel S, Majumder A, Goyal A. Potentials of Exopolysaccharides from Lactic Acid Bacteria. Indian J Microbiol 2012; 52: 3-12.
  • 20. Degeest B, Mozzi F, De Vuyst L. Effect of medium composition and temperature and pH changes on exopolysaccharide yields and stability during Streptococcus thermophilus LY03 fermentations. Int J Food Microbiol 2002; 79: 161-174.
  • 21. Cragg GM, Newman DJ, Snader KM. Natural products in drug discovery and development. J Nat Prod 1997; 60: 52-60.
  • 22. Madhuri KV, Vidya Prabhakar K. Microbial exopolysaccharides: biosynthesis and potential applications. Oriental J Chem 2014; 30: 14011410.
  • 23. Ramana KV, Xavier JR., Sharma RK. Recent Trends in Pharmaceutical Biotechnology. Pharmaceutical Biotechnology: Current Research 2017; 1 (1): 5.
  • 24. Mende S, Rohm H, Jaros D. Unfluence of exopolysaccharides on the structure, texture, stability and sensory properties of yoghurt and related products. Int Dairy J, 2016; 52: 57-71.
  • 25. Laws A, Gu Y, Marshall V. Biosynthesis, characterisation, and design of bacterial exopolysaccharides from lactic acid bacteria. Biotechnol Adv 2001; 19: 597–625.
  • 26. Kristo E, Miao Z, Corredig M. The role of exopolysaccharides produced by Lactococcus lactis subsp. cremoris in structure formation and recovery of acid milk gels. Int Dairy J 2011; 21: 656–662.
  • 27. Yang Z, Li S, Zhang X, Zeng X, Li D, Zhao Y, Zhang J. Capsular and slime-polysaccharide production by Lactobacillus rhamnosus JAAS8 isolated from Chinese sauerkraut: Potential application in fermented milk products. J Biosci Bioeng 2010; 110: 53-57.
  • 28. Kleerebezem M, Hugenholtz J. Metabolic pathway engineering in lactic acid bacteria. Curr Opin Biotechnol 2003; 14: 232-237.
  • 29. Welman AD, Maddox S. Exopolysaccharides from lactic acid bacteria: perspectives and challenges. Trends Biotechnol 2003; 21: 269-274.
  • 30. Kleerebezem M, Boels IC, Groot MN, Mierau I, Sybesma W, Hugenholtz J. Metabolic engineering of Lactococcus lactis: the impact of genomics and metabolic modelling. J Biotechnol 2002; 98: 199-213.
  • 31. Yang J, Zhang W, Shi P, Chen J, Han X, Wang Y. Effects of exopolysaccharide fraction (EPSF) from a cultivated Cordyceps sinensis fungus on c-Myc, c-Fos, and VEGF expression in B16 melanoma-bearing mice. Pathol Res Prac 2005; 201: 745–750.
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  • 33. Kitazawa H, Itoh T, Tomioka Y, Mizugaki M, Yamaguchi T. Induction of IFNγ and IL-1α production in macrophages stimulated with phosphopolysaccharide produced by Lactococcus lactis ssp. cremoris. Int J Food Microbiol 1996; 31: 99–106.
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Toplam 86 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Derlemeler
Yazarlar

Ümmügülsüm TÜKENMEZ

Belma ASLIM

Yayımlanma Tarihi 1 Aralık 2018
Gönderilme Tarihi 12 Ekim 2017
Kabul Tarihi 15 Şubat 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 25 Sayı: 4

Kaynak Göster

Vancouver TÜKENMEZ Ü, ASLIM B. Probiyotik Kaynaklı, Muhtemel Prebiyotik Özelliğe Sahip Ekzopolisakkarit (EPS)’ lerin Biyolojik ve Fonksiyonel Özellikleri. Med J SDU. 2018;25(4):487-9.