Probiyotik Kaynaklı, Muhtemel Prebiyotik Özelliğe Sahip Ekzopolisakkarit (EPS)’ lerin Biyolojik ve Fonksiyonel Özellikleri

Year 2018, Volume: 25 Issue: 4, 487 - 497, 01.12.2018

Ümmügülsüm Tükenmez , Belma Aslım

https://doi.org/10.17343/sdutfd.343111

Abstract

Kanser, günümüzün en önemli sağlık
sorunlarından birisidir ve dünyada en çok ölüme neden olan hastalıklardan
biridir. Kanser tedavisinde kullanılan mevcut anti-kanser ilaçlar doza bağlı
olarak toksisite göstermekte ve güçlü yan etkilere (enfeksiyon, saç dökülmesi,
yorgunluk, dudak yaraları, mide bulantısı, kusma, diyare ve kanlı dışkılar)
neden olmaktadır.  Dolayısıyla kanserin
tedavisinde etkili ve daha az toksik olan anti-kaser ajanların geliştirilmesine
ihtiyaç duyulmaktadır.  Laktik asit
bakterileri (LAB) gibi güvenilir ve doğal kaynaklardan elde edilen ekzopolisakkarit
(EPS)’lerin, sentetik anti-kanser ajanlarına göre iyi bir alternatif
olabileceği düşünülmektedir. Çeşitli
EPS’lerin yararlılığı EPS’nin monosakkarit kompozisyonuna, bağların türüne,
dallanma derecelerine ve molekül ağırlığına bağlı olduğu için bu derleme EPS’lerin
yapısı ve biyolojik aktivitesi ve EPS’lerin anti-kanser etkileri ile ilgili
bilgiler içermektedir.

 

Keywords

Anti-kanser, antioksidan, ekzopolisakkarit, laktik asit bakterileri, prebiyotik, probiyotik

Biological and Functional Properties of Possible Prebiotic Properties of Exopolysaccharides (EPSs) from Probiotics

Abstract

Nowadays, cancer is one of the most
important health problems and is one of the diseases that causes the most
deaths in the world. Existing anti-cancer drugs used in cancer treatment show
toxicity dose dependent manner and cause strong side effects (infection, hair
loss, fatigue, lip sores, nausea, vomiting, diarrhea and bloody feces). Therefore, there is a need to develop anti-cancer agents
that are effective and less toxic in the cancer treatment. Exopolysaccharides (EPSs)
obtained from safe and natural sources, such as lactic acid bacteria (LAB), are
thought to be a good alternative to synthetic anti-cancer agents. The
usefulness of the various EPSs is due to the fact that the EPS is dependent on
the monosaccharide composition, the ties of the bonds, the branching degrees
and the molecular weight, this review contains information on the structure and
biological activity of EPSs and the mechanism of anti-cancer action of EPSs.

Keywords

Anti-cancer, antioxidant, exopolyasccharide, lactic acid bacteria, prebiotic, probiotic

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