HUZUREVİNDE YAŞAYAN YAŞLILARDAKİ İLAÇ PROFİLİNİN DEĞERLENDİRİLMESİ: İLAÇ-İLAÇ ETKİLEŞİMİ ANALİZİ

Yıl 2018, Cilt: 25 Sayı: 4, 361 - 369, 01.12.2018

Mehtap Savran Halil Aşcı

https://doi.org/10.17343/sdutfd.403187

Öz

Giriş: Günümüzde hastalıkların
önlenmesi ve/veya erken dönemde teşhis/tedavi edilmesi ile ortalama yaşam
süresi artmıştır. Artan yaşam süresi kronik hastalıklar nedeniyle polifarmasiyi
beraberinde getirmekte bu nedenle yaşlı bakımında kalitenin azalmasına ve yaşlı
hizmet maliyetinin artışına yol açmaktadır.

Amaç: Bu çalışma Isparta Özel Huzurevi
ve Yaşlı Bakım Merkezi’nde yaşayan yaşlılardaki polifarmasi varlığı, pDDI’ların
sıklığı ve bunların tiplerinin değerlendirilmesini amaçlamaktadır.

Materyal
- Metod: Bu çalışma Isparta Özel Huzurevi ve Yaşlı Bakım
Merkezi’nde kesitsel tanımlayıcı nitelikte planlandı. Çalışma için Ağustos 2017
tarihinde huzurevinde yaşayan yaşlıların hasta dosyaları tarandı. Veriler
Lexi-Interact programı ile değerlendirildi.

Bulgular: Huzurevinde
yaşayan 61 yaşlının yaş ortalaması 79,16 
± 7,57 (65-94) yıl iken, yaşlıların 24’ü (% 39,3) kadın, 37’si erkek (%
60,7) idi. Huzurevi sakinlerinin huzurevinde kalma süresi ortalama 6,65  ± 8,53 (1- 35 yıl) yıl idi.

Huzurevinde kalan yaşlılarda kronik
hastalık olarak en sık hipertansiyon, gastroözefagial reflu, benign prostat
hipertrofisi ve diabetes mellitus saptandı.

Huzurevinde yaşayan 65 yaş üzeri
yaşlıların kullandıkları ilaçlar değerlendirildiğinde kişi başı ortalama ilaç
sayısı 3,14 ± 2,99 (0-12 adet) olarak bulundu. Polifarmasi ve pDDI arasında
istatistiksel olarak anlamlı bir ilişki tespit edildi (p<0.05)

Tartışma:
Yaşla birlikte artan ko-morbid hastalıklara bağlı polifarmasi ve yaşla birlikte
ortaya çıkan farmakokinetik ve farmakodinamik değişiklikler, yaşlıları advers
ilaç reaksiyonlarına yatkın hale getirir. Bu nedenle huzurevinde kalan
yaşlıların ilaç profilleri değerlendirilirken ilaçların potansiyel etkileşimler
yönünden değerlendirilmesinin uygun olacağı kanaatindeyiz.

‘Evaluation of Drug Profiles in
Elderly Living in Nursing Homes: Drug-Drug Interaction Analysis’

Summary

Introduction: Today, the average life span has
increased with the prevention of diseases and / or early diagnosis / treatment.
Increased life span brings polypharmacy due to chronic diseases, which leads to
decrease of quality in elderly care and increase of elderly service cost.

Objective: This study aims to
evaluate the prevalence of polypharmacy, pDDIs and their types in elderly
living in Isparta Private Nursing Home and Elderly Care Center.

Materials
and methods:
This study was planned as a cross-sectional descriptive feature in Isparta
Private Nursing Home and Elderly Care Center. The patient files of the elderly
living in the nursing home were screened on August 2017 for the study. The data
was evaluated using the Lexi-Interact program.

Findings: The mean age of 61 elderly
living in nursing homes was 79,16 ± 7,57 (65-94) years whereas 24 (39,3%) of
the elderly were female and 37 were male (60,7%). The average length of stay in
nursing home residents was 6.65 ± 8.53 (1- 35 years). Hypertension,
gastroesophageal reflux, benign prostatic hypertrophy and diabetes mellitus
were the most common chronic diseases. The average number of medicines per
person was 3.14 ± 2.99 (0-12). A statistically significant relationship was
found between polypharmacy and pDDI (p = 0,000)

Conclusion: Pharmacokinetic and
pharmacodynamic changes associated with polypharmacy and age associated with
increasing co-morbid diseases with age make the elderly susceptible to adverse
drug reactions. For this reason, we think that it would be appropriate to
evaluate drugs in terms of potential interactions when evaluating medication profiles of elderly
people living in nursing homes.

Anahtar Kelimeler

Yaşlı, Huzurevi, Polifarmasi

Kaynakça

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