FASTING SERUM GHRELIN LEVELS IS NEGATIVELY ASSOCIATED WITH BODY MASS INDEX, CHOLESTEROL, TRIGLYCERIDE AND C-REACTIVE PROTEIN

Yıl 2019, Cilt: 26 Sayı: 2, 141 - 149, 01.06.2019

Defne Cebeci Eda Evgen Tülüceoğlu Taner Gonca Nilüfer Şahin Calapoğlu Önder Öztürk Mustafa Calapoğlu

https://doi.org/10.17343/sdutfd.422561

Cited By: 1

Öz

Objective The aim of this study is to evaluate the relationship of ghrelin hormone with body mass index (BMI) in cohort of adult men and women subsequently categorized from normal weight to morbidly obese based on BMI criteria. The relationship among the total ghrelin, serum lipids and C-reactive protein (CRP) was also evaluated. Materials and Methods Two-hundred sixty men (n=151) and women (n=109) between the ages of 20 and 59 years were recruited from Sleep Disorder Center of Medicine Faculty of Süleyman Demirel University and of Isparta Gülkent State Hospital. Fasting plasma total ghrelin, CRP, serum lipids and glucose levels were measured after overnight fasting. Results Ghrelin levels were found to be statistically significantly lower in obese subjects (P<0.001), Glucose levels were clinically higher in obese subjects but not statistically significant. Fasting plasma ghrelin was negatively correlated with BMI, cholesterol, triglyceride (TG) and CRP (r=-0,402, P<0,01; r=0,259, p=0,01; r=0,137, p=0,05; r=0,146, p=0,05), respectively). There was weak significant correlation between ghrelin and glucose (r=0,131, p=0,05). Conclusion Obese subjects have low fasting ghrelin levels that they are significantly related to glucose, CRP, Cholesterol, triglyceride and body mass index. More prospective studies are needed to establish the role of ghrelin in the pathogenesis of human obesity. 

Anahtar Kelimeler

Obesity, Serum lipids, Inflammation, Adults, Ghrelin

AÇLIK SERUM GRELİN DÜZEYLERİ VÜCUT KİTLE İNDEKSİ, KOLESTEROL, TRİGLİSERİT VE C- REAKTİF PROTEİN İLE NEGATİF İLİŞKİLİDİR

Öz

Amaç: Bu çalışmanın amacı, vücut kitle indeksi (VKİ)
kriterlerine göre normal ağırlıktan morbid obeze kadar gruplandırılan erişkin
erkek ve kadın kohortunda grelin hormonunun VKİ, serum lipitleri ve C-reaktif
protein (CRP) ile ilişkisini değerlendirmektir.

Gereç
ve Yöntem: Isparta Gülkent
Devlet Hastanesi Göğüs Hastalıkları Uyku Laboratuarı
ve Süleyman Demirel
Üniversitesi Tıp Fakültesi Uyku Hastalıkları Merkezine başvuran 20-59 yaş arası
toplam iki yüz altmış erkek (n = 151) ve kadın (n = 109) çalışmaya dahil
edildi. Toplam grelin, CRP, serum lipitleri ve glukoz seviyeleri gece
açlığından sonra ölçüldü.

Bulgular: Grelin düzeyleri obez olgularda istatistiksel
olarak anlamlı derecede düşük bulundu (P <0.001), Glikoz düzeyleri obez
olgularda klinik olarak daha yüksekti ancak istatistiksel olarak anlamlı
değildi. Açlık plazma grelin, VKİ, kolesterol, trigliserid ve CRP ile negatif
korelasyonlar gösterdi (sırasıyla, r = -0.402, P <0.01; 0,259, p = 0,01;
0,137, p = 0,05; r = 0,146, p = 0,05). Grelin ve glukoz arasında zayıf anlamlı
korelasyon vardı (r = 0,131, p = 0,05).

Sonuç: Obez bireylerin grelin düzeylerinin düşük olması
glikoz, CRP, kolesterol, trigliserid ve vücut kitle indeksi ile anlamlı
derecede ilişkilidir. Grelinin insan obezitesinin patogenezindeki rolünü
belirlemek için daha ileriye dönük çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

Obezite, Serum lipidleri, İnflamasyon, Yetişkin, Grelin

Kaynakça

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