Parkinson Hastalığında Nöroinflamasyonun Rolü

Yıl 2019, Cilt: 26 Sayı: 3, 348 - 352, 01.09.2019

Elif Taşdemir

https://doi.org/10.17343/sdutfd.447542

Cited By: 1

Öz

Parkinson Hastalığı (PH), 65 yaş üzeri
kişilerde en sık görülen ikinci nörodejeneratif bozukluktur (1). Bu hastalık,
substantia nigra pars compacta’daki dopaminerjik nöronların progresif kaybı (2-4),
striatal dopamin seviyesinde azalma ve dopaminerjik liflerin kaybıyla
karakterizedir (5). PH’ndaki nöron dejenerasyon sürecinde; oksidatif stresin, aktive
edilmiş mikroglia hücrelerinin ve nöroinflamasyonun olduğu bilinmektedir (6).
PH, yoğun araştırma konusu olmasına rağmen hastalığın patogenezinde yatan
mekanizmalar tam olarak anlaşılamamıştır (7-8). Dolayısıyla, bu süreci tamamen
önleyen bir tedavi de bulunamamıştır. Bu derlemede, PH patogenezinde yer alan
nöroinflamasyon süreçleri incelenmiştir.

Anahtar Kelimeler

Parkinson hastalığı, nöroinflamasyon, mikroglia

Kaynakça

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