Oksidatif stres durumunda antioksidan enzimlerin rolü - Süperoksit dismutaz (SOD), katalaz (CAT) ve glutatyon peroksidaz (GPX)

Yıl 2019, Cilt: 26 Sayı: 3, 362 - 369, 01.09.2019

Rahime Aslankoç Deniz Demirci Ümmahan İnan Mahmut Yıldız Ahmet Öztürk Mevlüt Çetin Ecem Şirin Savran Burak Yılmaz

https://doi.org/10.17343/sdutfd.566969

Cited By: 11

Öz

Vücut enzimatik ve enzimatik olmayan karmaşık bir antioksidan savunma
sistemine sahiptir. Antioksidan mekanizmalar vücut dokuları için zararlı
etkilere sahip olan serbest radikallere karşı savunma sistemi geliştirirler.
Süperoksit dismutaz (SOD), katalaz (CAT) ve glutatyon peroksidaz (GPX) hücrede
serbest radikallere karşı temel savunma hattını oluştururlar. Serbest
radikaller özellikle mitokondriyal enerji üretim yoluyla sürekli olarak
üretilir.  

Serbest radikallerin hücrede birikmesi oksidatif strese ve hücresel
hasara neden olur. Hücre reaktif oksijen türlerinde artışın nörodejeneratif,
kardiyovasküler, diyebet ve böbrek hastalıkları gibi bir çok hastalıkların
patogenezinde rol oynadığı ifade edilmektedir. 
SOD, CAT ve GPx’in hücresel hasarı önlemedeki rolü sürekli olarak
araştırılmaktadır. 

Bu derleme makalesi, SOD, CAT ve GPX antioksidan enzimlerinin oksidatif
stresi önlemedeki rolünü açıklamak için yazılmıştır. 

Anahtar Kelimeler

Süperoksit dismutaz, Katalaz, Glutatyon peroksidaz, Oksidatif stres

Kaynakça

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