Yıl 2020, Cilt 27 , Sayı 1, Sayfalar 113 - 118 2020-03-01

Frequency of Iron Deficiency and Iron Deficiency Anemia in Fibromyalgia Syndrome
Fibromiyalji Sendromunda Demir Eksikliği ve Demir Eksikliği Anemisi Görülme Sıklığı

Fatih BAYGUTALP [1] , Duygu ALTINTAŞ [2] , Ayhan KUL [3]


Objective

Fibromyalgia syndrome (FMS), which is a chronic pain condition of unknown etiology, is mainly characterized by widespread pain, sleep disturbances, memory problems, and fatigue, which seriously impair quality of life. Decreased production of biogenic amine neurotransmitters as a result of decreased iron levels in the blood may play a role in the pathophysiology of FMS. This study aimed to investigate the prevalence of iron-deficiency and iron-deficiency anemia in patients with FMS and to draw attention to the prevalence of iron deficiency in patients with FMS.

Material and Methods

The patients who applied to the physical medicine and rehabilitation outpatient clinic of our hospital in the last five years, who were diagnosed as FMS and whose serum ferritin, total iron-binding capacity (TDBK), vitamin B12 concentrations and plasma hemoglobin concentrations were determined were analyzed retrospectively. Data were analyzed by using SPSS 23 package program.

Results

In the independent group comparisons between female and male patients with FMS, both plasma hemoglobin and serum iron levels were significantly lower in female patients than in male patients (p =0.009 and p = 0.002, respectively). There were no statistically significant differences between serum vitamin B12 levels and serum ferritin levels between male and female patients with FMS (p= 0.344, p=0,093 respectively). Besides, iron deficiency and iron deficiency anemia were observed in 28% and 12% of all FMS patients, respectively.

Conclusion

Measuring serum ferritin levels in FMS patients and treating iron deficiency when necessary is recommended to increase the success of FMS treatment. 

Amaç

Etiyolojisi tam olarak bilinmeyen kronik bir ağrı durumu olan fibromiyalji sendromu (FMS) temel olarak yaygın ağrı, uyku bozuklukları, hafıza sorunları ve yaşam kalitesini ciddi şekilde bozan yorgunluk ile karakterizedir. Kandaki azalmış demir seviyelerinin bir sonucu olarak biyojenik amin nörotransmiterlerinin üretimindeki azalma FMS'nin patofizyolojisinde rol oynayabilir. Bu çalışmada FMS'li hastalarda demir eksikliği ve demir eksikliği anemisinin prevalansının araştırılması ve FMS'li hastalarda demir eksikliği prevalansına dikkat çekilmesi amaçlanmıştır.

Gereç ve yöntem

Hastanemiz fiziksel tip ve rehabilitasyon polikliniği’ne son beş yıl içinde  müracaat eden hastalardan FMS tanısı alan ve serum ferritin, total demir bağlama kapasitesi (TDBK),vitamin B12 konstantrasyonları ile plazma hemoglobin konstantrasyonları belirlenmiş olan hastalar retrospektif olarak analiz edilmiştir.  Veriler SPSS 23 paket programı kullanılarak analiz edilmiştir.

Bulgular

FMS'li kadın ve erkek hastalar arasındaki bağımsız grup karşılaştırmalarında, plazma hemoglobin ve serum demir düzeylerinin kadın hastalarda erkek hastalara göre anlamlı derecede düşük olduğu görülmüştür (sırasıyla, p = 0.009 ve p = 0.002). FMS'li erkek ve kadın hastalar arasında serum B12 düzeyleri ile serum ferritin düzeyleri arasında istatistiksel olarak anlamlı bir fark yoktu (sırasıyla p = 0.344, p = 0,093). Ayrıca, tüm FMS hastalarının % 28’inde demir eksikliği ve% 12'sinde demir eksikliği anemisi olduğu belirlenmiştir.

Sonuç

FMS tedavisinde başarının artırılması için FMS hastalarında serum ferritin seviyelerinin ölçülmesi ve gerektiğinde demir eksikliğinin tedavi edilmesi önerilmektedir. 

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Birincil Dil en
Konular Tıp
Bölüm Araştırma Makaleleri
Yazarlar

Yazar: Fatih BAYGUTALP (Sorumlu Yazar)
Kurum: ATATÜRK ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR.
Ülke: Turkey


Yazar: Duygu ALTINTAŞ
Kurum: ATATÜRK ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR.
Ülke: Turkey


Yazar: Ayhan KUL
Kurum: ATATURK UNIVERSITY, FACULTY OF MEDICINE, MEDICINE PR.
Ülke: Turkey


Teşekkür We would like to express our gratitude to Dr. Hulki Aşır (MD) Head of Buhara Hospital for sharing data with us, and Professor Abdulbaki Bilgic from Department of Agricultural Economics, College of Agriculture, Atatürk University for analyzing the data for us.
Tarihler

Başvuru Tarihi : 17 Ekim 2019
Kabul Tarihi : 13 Şubat 2020
Yayımlanma Tarihi : 1 Mart 2020

Bibtex @araştırma makalesi { sdutfd634438, journal = {SDÜ Tıp Fakültesi Dergisi}, issn = {1300-7416}, eissn = {2602-2109}, address = {}, publisher = {Süleyman Demirel Üniversitesi}, year = {2020}, volume = {27}, pages = {113 - 118}, doi = {10.17343/sdutfd.634438}, title = {Frequency of Iron Deficiency and Iron Deficiency Anemia in Fibromyalgia Syndrome}, key = {cite}, author = {BAYGUTALP, Fatih and ALTINTAŞ, Duygu and KUL, Ayhan} }
APA BAYGUTALP, F , ALTINTAŞ, D , KUL, A . (2020). Frequency of Iron Deficiency and Iron Deficiency Anemia in Fibromyalgia Syndrome. SDÜ Tıp Fakültesi Dergisi , 27 (1) , 113-118 . DOI: 10.17343/sdutfd.634438
MLA BAYGUTALP, F , ALTINTAŞ, D , KUL, A . "Frequency of Iron Deficiency and Iron Deficiency Anemia in Fibromyalgia Syndrome". SDÜ Tıp Fakültesi Dergisi 27 (2020 ): 113-118 <https://dergipark.org.tr/tr/pub/sdutfd/issue/52788/634438>
Chicago BAYGUTALP, F , ALTINTAŞ, D , KUL, A . "Frequency of Iron Deficiency and Iron Deficiency Anemia in Fibromyalgia Syndrome". SDÜ Tıp Fakültesi Dergisi 27 (2020 ): 113-118
RIS TY - JOUR T1 - Frequency of Iron Deficiency and Iron Deficiency Anemia in Fibromyalgia Syndrome AU - Fatih BAYGUTALP , Duygu ALTINTAŞ , Ayhan KUL Y1 - 2020 PY - 2020 N1 - doi: 10.17343/sdutfd.634438 DO - 10.17343/sdutfd.634438 T2 - SDÜ Tıp Fakültesi Dergisi JF - Journal JO - JOR SP - 113 EP - 118 VL - 27 IS - 1 SN - 1300-7416-2602-2109 M3 - doi: 10.17343/sdutfd.634438 UR - https://doi.org/10.17343/sdutfd.634438 Y2 - 2020 ER -
EndNote %0 SDÜ Tıp Fakültesi Dergisi Frequency of Iron Deficiency and Iron Deficiency Anemia in Fibromyalgia Syndrome %A Fatih BAYGUTALP , Duygu ALTINTAŞ , Ayhan KUL %T Frequency of Iron Deficiency and Iron Deficiency Anemia in Fibromyalgia Syndrome %D 2020 %J SDÜ Tıp Fakültesi Dergisi %P 1300-7416-2602-2109 %V 27 %N 1 %R doi: 10.17343/sdutfd.634438 %U 10.17343/sdutfd.634438
ISNAD BAYGUTALP, Fatih , ALTINTAŞ, Duygu , KUL, Ayhan . "Frequency of Iron Deficiency and Iron Deficiency Anemia in Fibromyalgia Syndrome". SDÜ Tıp Fakültesi Dergisi 27 / 1 (Mart 2020): 113-118 . https://doi.org/10.17343/sdutfd.634438
AMA BAYGUTALP F , ALTINTAŞ D , KUL A . Frequency of Iron Deficiency and Iron Deficiency Anemia in Fibromyalgia Syndrome. SDÜ Tıp Fakültesi Dergisi. 2020; 27(1): 113-118.
Vancouver BAYGUTALP F , ALTINTAŞ D , KUL A . Frequency of Iron Deficiency and Iron Deficiency Anemia in Fibromyalgia Syndrome. SDÜ Tıp Fakültesi Dergisi. 2020; 27(1): 118-113.