Cell Therapies in Kidney Transplantation

Year 2020, Volume: 27 Issue: 3, 413 - 420, 01.09.2020

Özgür Şenol , Egemen Kaya , Volkan Karakuş

https://doi.org/10.17343/sdutfd.561701

Abstract

At
the present time, with the development of medicine, surgery and the use of
technologically advanced modern drugs, many diseases, including kidney
diseases, have  become treatable. Kidney
transplantation has become a treatment option for kidney diseases and kidney
transplant rates have increased as well as life expectancy has been prolonged
by means of obtained success. Immunosuppressive drugs are used in the
posttransplant treatment process of renal transplant patients. With the new
treatment options, it is aimed to increase the success rate of kidney
transplantation and also to eliminate the side effects which are caused by the
use of immunosuppressive drugs. Cellular therapies are one of the treatment
options that are studied for use in kidney transplantation. Regulator T cells,
regulator B cells, regulator macrophages, dendritic cells, mesenchymal stem
cells are cell sources that are searched and experimented for use in organ
transplantation. It has been shown that successful results have been obtained
by using cell therapies in studies carried out with experimental animal models
for transplantation. In this review, cell therapies used in and candidate
for  renal transplantation are discussed.

Keywords

Renal transplantation, cell therapy, regulatory T cell therapy, dendritic cell therapy, mesenchymal stem cell therapy

Böbrek Naklinde Hücresel Tedavilerin Kullanımı

Abstract

Günümüzde,
tıp, cerrahi alanında görülen gelişmeler ve teknolojik olarak geliştirilen
modern ilaçların kullanımıyla beraber, geçtiğimiz yüzyılda böbrek hastalıkları
da dahil olmak üzere, ölümcül olan birçok hastalık artık tedavi edilebilir
konuma gelmiştir. Böbrek nakli, elde edilen başarılar ile beraber,  hem böbrek hastalıkları için bir tedavi
seçeneği haline gelmiş ve böbrek nakil oranları artış göstermiş, hem de
beklenen yaşam süresi uzamıştır. Böbrek nakli yapılan hastaların cerrahi
sonrası tedavi süreçlerinde immünsüpresif ilaçlar kullanılmaktadır. Yeni
geliştirilmeye çalışılan tedavi seçenekleri ile hem böbrek naklinde elde edilen
başarı oranı arttırılmaya çalışılmakta hem de immünsüpresif ilaçların
kullanımının yol açtığı yan etkilerin giderilmesi amaçlanmaktadır. Hücresel
tedaviler de böbrek naklinde kullanılması için üzerinde çalışılan tedavi
seçeneklerinden bir tanesidir. Regülatör T hücreler, regülatör B hücreler, regülatör
makrofajlar, dendritik hücreler, mezenkimal kök hücreler, organ nakillerinde
kullanılması için araştırma ve deneme yapılan hücre kaynaklarındandır. Deney
hayvanlarında nakil modellerinde yapılan çalışmalarda, hücre tedavileri ile
başarılı sonuçlar alındığı gösterilmiştir. Bu derlemede böbrek naklinde
kullanılan ve de kullanılmaya aday olan hücre tedavileri tartışılmıştır.

Keywords

Böbrek Nakli, hücre tedavisi, regülatör T hücre tedavisi, dendritik hücre tedavisi, mezenkimal kök hücre tedavisi

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