Salvage Treatment Option for Metastatic Colorectal Cancer:Regorafenib

Year 2020, Volume: 27 Issue: 4, 471 - 476, 25.12.2020

Havva Yesil Cinkir

https://doi.org/10.17343/sdutfd.581299

Abstract

Introduction: Colorectal
cancer (CRC) is an important cause of
cancer-related deaths. The aim of this study was to
evaluate the efficacy and toxicity profile of regorafenib treatment in metastatic
CRC patients.

Methods: This was a
retrospective study of 25 mCRC patients from a single center. All patients had
previously progressed fluorouracil, irinotecan, and oxaliplatin with or without
biologic agents such as epidermal growth factor receptör (anti-EGFR) or
vascular endothelial growth factor receptor (anti-VEGF).

Results: The median age
was 58 years
(range, 27 to 84 years), and there were 14 males and 11 females. Patients had received a median of 3 lines of systemic
therapy before regorafenib initiation. The most common grade 3 or 4
toxicities were fatigue 20%, daire 16% and mucositis 16%. Median PFS was 2.07
months (0.43-5.13) and median OS was 4.14 months (0.62-19.88). No factors were
significantly associated with PFS and OS 
in the univariate analysis.

                        Conclusion: Regorafenib shows a small but significant
survival benefit in patients with metastatic CRC who do not have any

                       further
treatment options after the failure over standard therapies. Its toxicity
profile along with the absence of predictive factors

                       suggest a careful
evaluation before its use in clinical practice

Keywords

colorectal cancer, regorafenib, toxicity

Supporting Institution

The author declared that this study received no financial support

Metastatik Kolorektal Kanserde Kurtarma Tedavisi:Regorafenib

Abstract

Giriş: Kolorektal
kanser (KRK), kanser ilişkili ölümlerin önemli nedenlerinden biridir. Bu çalışmanın amacı, metastatik KRK hastalarında
regorafenib tedavisinin etkinlik ve toksisite profilini değerlendirmektir.

Method:
Bu
çalışmada tek merkezde takip edilen 25 mKRK hastasının retrospektif verileri
incelenmiştir. Tüm hastalarda biyolojik ajanlar olan anti-epidermal büyüme
faktörü reseptörü (anti-EGFR) ve anti-vasküler endotelyal büyüme faktörü
(anti-VEGF) ile kombine olarak veya olmaksızın 5-fluorourasil, irinotekan ve okzaliplatin
ile progresyon saptanmıştı.

Bulgular: Ortanca yaş 58
(dağılım 27-84) idi, ve 14 erkek ve 11 kadın vardı. Hastalar regorafenib
başlangıcından önce ortanca 3 sıra sistemik tedavi aldılar. En sık görülen
derece 3. veya 4. derece toksisiteler yorgunluk %20, daire %16 ve mukozit %16
idi. Ortanca PFS 2.07 ay (0.43-5.13) ve ortanca OS 4.14 ay (0.62-19.88) idi. Tek
değişkenli analizde hiçbir faktör PFS ve OS ile ilişkili bulunmadı.

Sonuç: Regorafenib,
standart tedavilerdeki başarısızlıktan sonra başka tedavi seçeneği bulunmayan metastatik
KRK hastalarında küçük fakat önemli bir sağkalım yararı göstermektedir.
Prediktif faktörlerin olmamasıyla birlikte toksisite profili klinik uygulamada
kullanılmadan önce dikkatli bir değerlendirme yapılmasını önerir.

Keywords

kolorektal kanser, regorafenib, yan etki

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