THE ROLE AND IMPORTANCE OF miRNA PROFILES IN PATIENTS WITH FIBROMYALGIA SYNDROME

Yıl 2021, Cilt: 28 Sayı: 3, 529 - 533, 13.09.2021

Khayala Rasulova Melek Pehlivan Banu Dilek Sefa Kızıldağ

https://doi.org/10.17343/sdutfd.792825

Öz

Fibromyalgia syndrome (FMS) is a chronic musculoskeletal
pain disorder associated with other symptoms.
It is mainly characterized by pain, fatigue, and sleep
disturbance. Many other genetic, immunological, and
hormonal factors play an important role in the etiology
of fibromyalgia. This pathological condition affects
approximately 3-10% of the population. The incidence
of the disease is more often in women. Women show
more severe symptoms and lower pain threshold than
men. Therefore, most of the research has focused on
female subjects.
MicroRNAs (miRNAs) regulate at least 30% of
human genes. In recent years, miRNAs have been
identified as important modulators of gene expression
in disease processes and physiological pathways.
However, each microRNA may be responsible for
regulation of hundreds of genes. miRNAs inhibit the
gene expression after transcription through inhibition
of translation or degradation of target messenger RNA.
The purpose of this review is to discuss the role of
miRNAs in FMS disease. According to the studies,
some miRNA expression levels were changed in FMS
patients. The presence of microRNAs in different
cellular compartments and their extracellular stability
make them interesting candidate biomarkers for better
understanding the etiology of complex diseases such
as FMS.

Anahtar Kelimeler

Fibromyalgia, miRNA, biomarkers

FİBROMİYALJİ SENDROMU OLAN HASTALARDA miRNA PROFİLLERİNİN ROLÜ VE ÖNEMİ

Öz

Fibromiyalji sendromu (FMS), diğer semptomlarla ilişkili
kronik kas-iskelet sistemi ağrı bozukluğudur. Esas
olarak ağrı, yorgunluk ve uyku bozukluğu ile karakterizedir.
Fibromiyaljinin etiyolojisinde genetik, immünolojik
ve hormonal birçok faktör önemli rol oynamaktadır.
Bu patolojik durum popülasyonun yaklaşık %3-10'unu
etkilemektedir. Görülme sıklığı açısından, kadınlarda
erkeklerden daha fazla görülmektedir. Kadınlar erkeklerden
daha şiddetli belirtiler ve daha düşük ağrı eşiği
göstermektedir. Bu yüzden araştırmaların çoğu kadın
deneklere odaklanmıştır.
MikroRNA'lar (miRNA), insan genlerinin en az %30'
unu düzenlemektedirler. Son yıllarda miRNA’lar hastalık
süreçlerinde ve fizyolojik yolaklarda gen ekspresyonunun
önemli modülatörleri olarak tanımlanmıştır.
Bununla birlikte her miRNA yüzlerce genin regülasyonundan
sorumlu olabilir. miRNA’lar translasyonun
engellenmesi veya hedef haberci RNA'nın yıkımı yoluyla
transkripsiyon sonrası gen ekspresyonunu inhibe
ederler.
Bu derlemenin amacı miRNA’ların FMS hastalığındaki
rolünü tartışmaktır. Yapılan çalışmalara göre, FMS
hastalarında bazı miRNA ekspresyon düzeylerinin
değiştiği saptanmıştır. Farklı hücresel bölmelerdeki
miRNA'ların varlığı ve hücre dışı ortamdaki kararlılıkları,
FMS gibi karmaşık hastalıkların etiyolojisini daha
iyi anlamak için onları ilgi çekici aday biyobelirteçler
yapmaktadır.

Anahtar Kelimeler

Fİbromyalji, miRNA, biyobelirteç

Kaynakça

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