GASTRIC METASTASIS OF RENAL CELL CARCINOMA: A CASE REPORT

Yıl 2021, Cilt: 28 Sayı: 4, 681 - 685, 30.12.2021

Gamze Erkılınç , Sema Bircan , Şirin Başpınar , Şehnaz Evrimler , Altuğ Şenol , Onur Ertunç , Bülent Çetin

https://doi.org/10.17343/sdutfd.871112

Öz

Primary gastric tumors are encountered more frequently
than metastatic tumors. The gastric metastasis of clear
cell renal cell carcinoma (CCRC) is very rare. We
herein report a case of gastric metastasis of CCRC.
A sixty-year-old man patient underwent a radical
nephrectomy and received adjuvant chemotherapy.
Pulmonary metastasis occurred at the second-year
follow-up, and interferon alpha-2a was used for
relapse. The Computed Tomography examination of
the patient presented with dyspepsia two years after
pulmonary metastases revealed 11 mm thickness in
the (along) gastric wall. Endoscopic examination was
suggestive of a neuroendocrine tumor.
Histopathologic evaluation of endoscopic biopsies
showed tumoral cell groups in a solid pattern composed
of clear, vacuolated cytoplasm. These tumor cells
were positive for RCC, PAX8 CD-10, Vimentin, and
immunohistochemistry findings were similar to the
initial tumor at diagnosis. Finally, the patient was
diagnosed with CCRC's gastric metastasis and treated
with a multi-targeted receptor tyrosine kinase inhibitor.

Anahtar Kelimeler

gastric metastasis, clear cell, renal carcinoma, immunohistochemistry

Destekleyen Kurum

none

Proje Numarası

-

Teşekkür

none

RENAL HÜCRELİ KARSİNOMUN MİDEYE METASTAZI: OLGU SUNUMU

Öz

Primer mide tümörlerine, metastatik tümörlerinden
daha sık rastlanır. Berrak hücreli renal hücreli karsinomun
(BHRHK) mideye metastazı çok nadirdir. Bu yazıda
BHRHK’un mideye metastazı olgusunu sunduk.
Altmış yaşında erkek hasta radikal nefrektomi geçirdi
ve adjuvan kemoterapi aldı. Takibinde ikinci yılda
pulmoner metastaz izlendi ve relaps için interferon alfa-
2a kullanıldı. Akciğer metastazlarından iki yıl sonra
dispepsi ile başvuran hastanın bilgisayarlı tomografik
incelemesinde mide duvarında (boyunca) 11 mm
kalınlık saptandı. Endoskopik inceleme nöroendokrin
tümörü düşündürdü.
Histopatolojik incelemede berrak vakuolize sitoplazmalı
solid paternde tümöral hücre grupları gözlendi.
Tümör hücreleri RCC, PAX8, CD10, Vimentin ile pozitif
olup immünhistokimyasal sonuçlar ilk tümör ile
benzerdi. Sonuç olarak olguya BHRHK’un mide metastazı
tanısı verildi ve çok hedefli bir reseptör tirozin
kinaz inhibitörü ile tedavi edildi.

Anahtar Kelimeler

mide metastazı, berrak hücre, renal karsinom, immünhistokimya

Proje Numarası

-

Kaynakça

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