GASTRIC METASTASIS OF RENAL CELL CARCINOMA: A CASE REPORT

Year 2021, Volume: 28 Issue: 4, 681 - 685, 30.12.2021

Gamze Erkılınç , Sema Bircan , Şirin Başpınar , Şehnaz Evrimler , Altuğ Şenol , Onur Ertunç , Bülent Çetin

https://doi.org/10.17343/sdutfd.871112

Abstract

Primary gastric tumors are encountered more frequently
than metastatic tumors. The gastric metastasis of clear
cell renal cell carcinoma (CCRC) is very rare. We
herein report a case of gastric metastasis of CCRC.
A sixty-year-old man patient underwent a radical
nephrectomy and received adjuvant chemotherapy.
Pulmonary metastasis occurred at the second-year
follow-up, and interferon alpha-2a was used for
relapse. The Computed Tomography examination of
the patient presented with dyspepsia two years after
pulmonary metastases revealed 11 mm thickness in
the (along) gastric wall. Endoscopic examination was
suggestive of a neuroendocrine tumor.
Histopathologic evaluation of endoscopic biopsies
showed tumoral cell groups in a solid pattern composed
of clear, vacuolated cytoplasm. These tumor cells
were positive for RCC, PAX8 CD-10, Vimentin, and
immunohistochemistry findings were similar to the
initial tumor at diagnosis. Finally, the patient was
diagnosed with CCRC's gastric metastasis and treated
with a multi-targeted receptor tyrosine kinase inhibitor.

Keywords

gastric metastasis, clear cell, renal carcinoma, immunohistochemistry

Supporting Institution

none

Project Number

-

Thanks

none

RENAL HÜCRELİ KARSİNOMUN MİDEYE METASTAZI: OLGU SUNUMU

Abstract

Primer mide tümörlerine, metastatik tümörlerinden
daha sık rastlanır. Berrak hücreli renal hücreli karsinomun
(BHRHK) mideye metastazı çok nadirdir. Bu yazıda
BHRHK’un mideye metastazı olgusunu sunduk.
Altmış yaşında erkek hasta radikal nefrektomi geçirdi
ve adjuvan kemoterapi aldı. Takibinde ikinci yılda
pulmoner metastaz izlendi ve relaps için interferon alfa-
2a kullanıldı. Akciğer metastazlarından iki yıl sonra
dispepsi ile başvuran hastanın bilgisayarlı tomografik
incelemesinde mide duvarında (boyunca) 11 mm
kalınlık saptandı. Endoskopik inceleme nöroendokrin
tümörü düşündürdü.
Histopatolojik incelemede berrak vakuolize sitoplazmalı
solid paternde tümöral hücre grupları gözlendi.
Tümör hücreleri RCC, PAX8, CD10, Vimentin ile pozitif
olup immünhistokimyasal sonuçlar ilk tümör ile
benzerdi. Sonuç olarak olguya BHRHK’un mide metastazı
tanısı verildi ve çok hedefli bir reseptör tirozin
kinaz inhibitörü ile tedavi edildi.

Keywords

mide metastazı, berrak hücre, renal karsinom, immünhistokimya

Project Number

-

References

• 1. Namikawa T, Hanazaki K. Clinicopathological features and treatment outcomes of metastatic tumors in the stomach. Surgery today. 2014;44(8):1392-9.
• 2. Sakurai K, Muguruma K, Yamazoe S, Kimura K, Toyokawa T, Amano R, et al. Gastric metastasis from renal cell carcinoma with gastrointestinal bleeding: a case report and review of the literature. International surgery. 2014;99(1):86-90.
• 3. Green LK. Hematogenous metastases to the stomach. A review of 67 cases. Cancer. 1990;65(7):1596-600.
• 4. Davis GH, Zollinger RW. Metastatic melanoma of the stomach. The American Journal of Surgery. 1960;99(1):94-6.
• 5. Gupta K, Miller JD, Li JZ, Russell MW, Charbonneau C. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer treatment reviews. 2008;34(3):193-205.
• 6. Zhou, Ming, et al. "Protocol for the Examination of Specimens from Patients with Carcinoma of the Ureter and Renal Pelvis." (2017).
• 7. Kobayashi O, Murakami H, Yoshida T, Cho H, Yoshikawa T, Tsuburaya A, et al. Clinical diagnosis of metastatic gastric tumors: clinicopathologic findings and prognosis of nine patients in a single cancer center. World Journal of Surgery. 2004;28(6):548-51.
• 8. Pollheimer MJ, Hinterleitner TA, Pollheimer VS, Schlemmer A, Langner C. Renal cell carcinoma metastatic to the stomach: single‐centre experience and literature review. BJU international. 2008;102(3):315-9.
• 9. Menuck LS, Amberg JR. Metastatic disease involving the stomach. The American Journal of digestive diseases. 1975;20(10):903-13.
• 10. Oda I, Kondo H, Yamao T, Saito D, Ono H, Gotoda T, et al. Metastatic tumors to the stomach: analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases. Endoscopy. 2001;33(06):507-10.
• 11. de Oliveira Campoli PM, Ejima FH, Cardoso DMM, da Silva OQ, Santana Filho JB, de Queiroz Barreto PA, et al. Metastatic cancer to the stomach. Gastric Cancer. 2006;9(1):19-25.
• 12. Eslick GD, Kalantar JS. Gastric metastasis in renal cell carcinoma: a case report and systematic review. Journal of gastrointestinal cancer. 2011;42(4):296-301.
• 13. Blake M, Owens A, O'Donoghue D, MacErlean D. Embolotherapy for massive upper gastrointestinal haemorrhage secondary to metastatic renal cell carcinoma: report of three cases. Gut. 1995;37(6):835-7.
• 14. Kim M-Y, Jung H-Y, Choi KD, Song HJ, Lee JH, Kim DH, et al. Solitary synchronous metastatic gastric cancer arising from t1b renal cell carcinoma: a case report and systematic review. Gut and Liver. 2012;6(3):388.
• 15. De Palma GD, Masone S, Rega M, Simeoli I, Donisi M, Addeo P, et al. Metastatic tumors to the stomach: clinical and endoscopic features. World journal of gastroenterology: WJG. 2006;12(45):7326.
• 16. Dassen A, Lips D, Hoekstra C, Pruijt J, Bosscha K. FDG-PET has no definite role in preoperative imaging in gastric cancer. European Journal of Surgical Oncology (EJSO). 2009;35(5):449-55.
• 17. Sakai Y, Kanomata N, Itami H, Kajimoto K, Sakuma T, Ohbayashi C. Signet-ring cell carcinoma of the stomach metastasizing to renal cell carcinoma: a case report and review of the literature. Kobe J Med Sci. 2010;55(6):E122-31.
• 18. Patel P, Chaganti R, Motzer R. Targeted therapy for metastatic renal cell carcinoma. British Journal of cancer. 2006;94(5):614-9.
• 19. Cohen H. McGovern fJ: Renal-cell carcinoma. N engl J Med. 2005;353:2477-90
• 20. SEER Stat Fact Sheets: Kidney and Renal Pelvis http://seer.cancer.gov/statfacts/html/kidrp.html.