MOLECULAR PATHOGENESIS OF PROSTATE CANCER

Yıl 2022, Cilt: 29 Sayı: 4, 697 - 706, 27.12.2022

Onur Ertunç Burçin Tuna

https://doi.org/10.17343/sdutfd.1120510

Öz

Prostate cancer is the second most common cause
of death in men worldwide, after lung carcinoma.
Although early treatment and preventive medicine
practices came to the fore in the era of PSA followup,
and subsequent needle biopsies made it easier
to detect the tumor development of the patients, but
we did not have much chance in terms of determining
the behavior of the tumor especially before, during
and after the treatment, except for risk scoring
schemes. Today, the molecular signature and
molecular biology of the disease, which we can use to
determine individual treatment models and to predict
the prognosis of the disease, are important. For all
these reasons, medical professional's knowledge of
the molecular pathogenesis and biological attitude of
prostate cancer will help to understand the disease
and its course.

Anahtar Kelimeler

Advanced disease, Biology of prostate, ETS positive and negative PCa, Molecular pathogenesis, Prostate cancer, ETS pozitif ve negatif PCa, İleri evre hastalık, Moleküler patogenez, Prostat biyolojisi, Prostat kanseri

PROSTAT KANSERİ MOLEKÜLER PATOGENEZİ

Öz

Prostat kanseri dünya genelinde erkeklerde akciğer
karsinomundan sonra 2. en sık ölüme yol açan
kanserlerdir. Her ne kadar erken tedavi ve koruyucu
hekimlik uygulamalarının PSA takibi şeklinde ön plana
çıkmasıyla, devamında iğne biyopsilerle hastaların
tümör gelişiminin saptanması kolaylaşmış olsa
da tümörün özellikle tedavi öncesinde, sırasında ve
sonrasındaki davranışlarının belirlenmesi anlamında
elimizde risk skorlama şemaları dışında pek bir şansımız
yoktu. Günümüzde kişiye özgü tedavi modellerini
belirlemede ve hastalığın ileri evre olmadan prognozunu
tahmin etmede kullanabileceğimiz moleküler imzası
ve moleküler biyolojisi önem arz etmektedir. Tüm
bu nedenlerle prostat kanserinin moleküler patogenezi
ve biyolojik davranışının medikal profesyoneller tarafından
bilinmesi hastalığı ve seyrini anlamada bize
yardımcı olacaktır.

Anahtar Kelimeler

ETS pozitif ve negatif PCa, İleri evre hastalık, Moleküler patogenez, Prostat biyolojisi, Prostat kanseri

Kaynakça

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