THE RELATION BETWEEN MODIFIED SYSTEMIC INFLAMMATION SCORE AND PROGNOSTIC MARKERS OF GASTROINTESTINAL STROMAL TUMORS

Year 2023, Volume: 30 Issue: 4, 698 - 702, 30.12.2023

Fırat Canlıkarakaya , Serhat Ocaklı , Cengiz Ceylan , Abidin Göktaş , İlkay Güler , Serdar Gökay Terzioğlu

https://doi.org/10.17343/sdutfd.1382872

Abstract

Objective
Gastrointestinal stromal tumours are tumours of
mesenchymal origin that can be located along
the gastrointestinal tract. In this study, the role of
Modified systemic inflammation score in predicting
the prognosis of these tumours was investigated.
Material and Method
115 patients diagnosed with Gastrointestinal Stromal
Tumor (GIST) who underwent surgery at Ankara City
Hospital between June 1, 2019 and December 1,
2022 were examined. Tumor location, size, presence
of rupture-bleeding-necrosis, Ki-67 level, mitotic index
and preoperative albumin, lymphocyte and monocyte
levels were evaluated. mSIS score was grouped as
0, 1 and 2. The relationship between mSIS and Ki-
67 index and the presence of rupture, necrosis and
bleeding was investigated.
Results
Out of 115 patients, 68 (59 %) were male, 47 (41 %)
were female, with an average age of 62.5 (± 12.67)
years. Tumor locations: stomach (64.3 %), small
intestine (26 %), colon (5.2 %), esophagus (1.8 %),
pancreas (1.8 %), and ovary (0.9 %). Necrosis was
in 25 (30.7 %), hemorrhage in 67 (58.7 %), rupture
in 19 (16.8 %), and the mean Ki-67 level was 9.09 (±
10.64). 63 (54.8 %) patients had mSIS 0, 29 (25.2 %)
had mSIS 1, and 23 (20 %) had mSIS 2. Statistical
analysis found a significant correlation between mSIS
and necrosis, but not with other parameters.
Conclusion
The mSIS score is a valuable score showing
inflammation in the body and has been shown to be
associated with the prognosis of many malignancies.
In our study, the presence of necrosis in the tumour
was found to be associated with the mSIS score.
Although this result alone is not sufficient to predict
the prognosis, it is thought to be an issue that may
open the door to new studies.

Keywords

Gastrointestinal stromal tumour, Modified systemic inflammation score, Prognosis, Tumour necrosis

MODİFİYE SİSTEMİK İNFLAMASYON SKORU İLE GASTROİNTESTİNAL STROMAL TÜMÖRLERİN PROGNOSTİK GÖSTERGELERİ ARASINDAKİ İLİŞKİ

Abstract

Amaç
Gastrointestinal stromal tümörler, gastrointestinal sistem
boyunca yerleşebilen mezenkimal kökenli tümörlerdir.
Bu çalışmada Modifiye sistemik inflamasyon
skorunun (mSIS) bu tümörlerin prognozunu öngörmedeki
rolü araştırıldı.
Gereç ve Yöntem
1 Haziran 2019 ile 1 Aralık 2022 tarihleri arasında
Ankara Şehir Hastanesi'nde ameliyat edilen Gastrointestinal
Stromal Tümör (GIST) tanısı alan 115 hasta
incelendi. Tümörün lokalizasyonu, boyutu, rüptür-kanama-
nekroz varlığı, ki-67 düzeyi, mitotik indeks ve
ameliyat öncesi albümin, lenfosit ve monosit düzeyleri
değerlendirildi. mSIS skoru 0, 1 ve 2 olarak gruplandırıldı.
mSIS ile Ki-67 indeksi, rüptür, nekroz ve kanama
varlığı ile ilişkisi araştırıldı.
Bulgular
115 hastanın 68'i (% 59) erkek, 47'si (% 41) kadın
olup yaş ortalaması 62,5 (± 12,67) idi. Tümör lokasyonları:
mide (% 64,3), ince bağırsak (% 26), kolon
(% 5,2), yemek borusu (% 1,8), pankreas (% 1,8) ve
yumurtalık (% 0,9). 25'inde (% 30,7) nekroz, 67'sinde
(% 58,7) kanama, 19'unda (% 16,8) rüptür vardı ve
ortalama Ki-67 düzeyi 9,09 (± 10,64) idi. Hastaların
63'ünde (% 54,8) mSIS 0, 29'unda (% 25,2) mSIS 1
ve 23'ünde (% 20) mSIS 2 vardı. İstatistiksel analizlerde,
mSIS ile nekroz mevcudiyeti arasında anlamlı bir
korelasyon bulundu.
Sonuç
mSIS skoru vücuttaki inflamasyonu gösteren değerli
bir skordur ve birçok malignitenin prognozu ile ilişkili
olduğu gösterilmiştir. Çalışmamızda tümörde nekroz
varlığı mSIS skoru ile ilişkili bulunmuştur. Bu sonuç
tek başına prognozu tahmin etmek için yeterli olmasa
da yeni çalışmalara kapı açabilecek bir konu olduğu
düşünülmektedir.

Keywords

Gastrointestinal stromal tümör, Modifiye sistemik inflamasyon skoru, Prognoz, Tümör nekrozu

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