Radyoterapiyi takiben kritik boyutta oluşturulan kemik defektlerinde antibiyotiklerin etkinliğinin deneysel olarak incelenmesi

Özgün Günay; Özge Doğanay; Olgu Enis Tok; Alper Alkan

doi:10.15311/selcukdentj.695767

Radyoterapiyi takiben kritik boyutta oluşturulan kemik defektlerinde antibiyotiklerin etkinliğinin deneysel olarak incelenmesi

Abstract

Amaç: Çenelerin osteoradyonekrozu (ORN), baş ve boyun kanserlerinde radyasyon tedavisinin bir komplikasyonu olarak karşımıza çıkmaktadır. Tanımı ve sınıflandırması yıllar içinde değişiklik göstermiş, patofizyolojisine dair teorileri geliştirilmiş ve buna bağlı olarak farklı tedavi prensipleri denenmiştir. Çalışmadaki amacımız, radyoterapiyi takiben alt çene kemiğinde cerrahi olarak oluşturulan kritik boyuttaki defektlerde klindamisin, metronidazol, rifamisin ve doksisiklin grubu antibiyotiklerin kemik iyileşmesi üzerindeki etkilerini incelemekti. Gereç ve Yöntem: Anti-enflamatuar etkinliğin kemik iyileşmesi üzerindeki etkilerini değerlendirmek için, 50 adet Wistar cinsi albino türü sıçanlar kullanılmıştır. Tüm gruplara genel anestezi altında 30 Gy dozda radyoterapi uygulandıktan 8 hafta sonra sıçanların sağ mandibulasında 5 mm çapında bikortikal hazırlanan kemik defektlerine deney gruplarında ksenogreft ile karıştırılan antibiyotikler, kontrol gruplarında ise sadece ksenogreft partikülleri uygulanarak cerrahi saha iyileşmeye bırakılmıştır. Sakrifikasyon sonrasında elde edilen örneklerde enflamasyon, nekroz, fibrozis, yeni kemik yapım alanı, kalsifiye olmuş kemik alanı ve kapiller sayısı histopatolojik ve histomorfometrik olarak değerlendirildi. Bulgular: İncelenen kesitlerde nekroz, enfeksiyon ya da fibrozis bulgusuna rastlanmamıştır. Kontrol grubu ile yapılan karşılaştırmalarda metronidazol ve klindamisin gruplarında yeni kemik yapım alanlarının anlamlı derecede yüksek olduğu görülmüştür (p<0.01, p<0.01). Kalsifiye kemik trabekül alanları incelendiğinde kontrol grubu ile klindamisin grubu arasında istatistiksel olarak ileri derecede anlamlı fark tespit edilmiştir (p<0.01). Klindamisin ile diğer gruplar karşılaştırıldığında ise aradaki fark anlamlı (p<0.05) bulunmuştur. Kontrol grubu ile yapılan karşılaştırmalarda kapiller sayısı metronidazol grubunda anlamlı (p<0.05), klindamisin grubunda (p<0.01) ise ileri derecede anlamlı olarak farklı bulunmuştur. Sonuç: Antibiyotik uygulanan gruplarda iltihabi alanların sayısında azalma, yeni kemik yapım alanlarında ve damarlanmada artış gözlenmiştir. Çalışmada kullandığımız antibiyotiklerin antibakteriyel aktiviteden bağımsız olarak anti- enflamatuar etkinliklerinin olabileceği düşünülmektedir.

Keywords

References

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Details

Primary Language

Turkish

Subjects

Dentistry

Journal Section

Research Article

Authors

Özgün Günay This is me
0000-0001-5209-5361
Türkiye

Özge Doğanay ^*
0000-0001-5695-4944
Türkiye

Olgu Enis Tok This is me
0000-0002-4899-9146
Türkiye

Alper Alkan This is me
Türkiye

Publication Date

August 1, 2020

Submission Date

February 29, 2020

Acceptance Date

April 6, 2020

Published in Issue

Year 2020 Volume: 7 Number: 2

DOI

https://doi.org/10.15311/selcukdentj.695767

IZ

https://izlik.org/JA43LE22UP

Cite

RIS / Bibtex

APA

Günay, Ö., Doğanay, Ö., Tok, O. E., & Alkan, A. (2020). Radyoterapiyi takiben kritik boyutta oluşturulan kemik defektlerinde antibiyotiklerin etkinliğinin deneysel olarak incelenmesi. Selcuk Dental Journal, 7(2), 294-303. https://doi.org/10.15311/selcukdentj.695767

AMA

1.Günay Ö, Doğanay Ö, Tok OE, Alkan A. Radyoterapiyi takiben kritik boyutta oluşturulan kemik defektlerinde antibiyotiklerin etkinliğinin deneysel olarak incelenmesi. Selcuk Dent J. 2020;7(2):294-303. doi:10.15311/selcukdentj.695767

Chicago

Günay, Özgün, Özge Doğanay, Olgu Enis Tok, and Alper Alkan. 2020. “Radyoterapiyi Takiben Kritik Boyutta Oluşturulan Kemik Defektlerinde Antibiyotiklerin Etkinliğinin Deneysel Olarak Incelenmesi”. Selcuk Dental Journal 7 (2): 294-303. https://doi.org/10.15311/selcukdentj.695767.

EndNote

Günay Ö, Doğanay Ö, Tok OE, Alkan A (August 1, 2020) Radyoterapiyi takiben kritik boyutta oluşturulan kemik defektlerinde antibiyotiklerin etkinliğinin deneysel olarak incelenmesi. Selcuk Dental Journal 7 2 294–303.

IEEE

[1]Ö. Günay, Ö. Doğanay, O. E. Tok, and A. Alkan, “Radyoterapiyi takiben kritik boyutta oluşturulan kemik defektlerinde antibiyotiklerin etkinliğinin deneysel olarak incelenmesi”, Selcuk Dent J, vol. 7, no. 2, pp. 294–303, Aug. 2020, doi: 10.15311/selcukdentj.695767.

ISNAD

Günay, Özgün - Doğanay, Özge - Tok, Olgu Enis - Alkan, Alper. “Radyoterapiyi Takiben Kritik Boyutta Oluşturulan Kemik Defektlerinde Antibiyotiklerin Etkinliğinin Deneysel Olarak Incelenmesi”. Selcuk Dental Journal 7/2 (August 1, 2020): 294-303. https://doi.org/10.15311/selcukdentj.695767.

JAMA

1.Günay Ö, Doğanay Ö, Tok OE, Alkan A. Radyoterapiyi takiben kritik boyutta oluşturulan kemik defektlerinde antibiyotiklerin etkinliğinin deneysel olarak incelenmesi. Selcuk Dent J. 2020;7:294–303.

MLA

Günay, Özgün, et al. “Radyoterapiyi Takiben Kritik Boyutta Oluşturulan Kemik Defektlerinde Antibiyotiklerin Etkinliğinin Deneysel Olarak Incelenmesi”. Selcuk Dental Journal, vol. 7, no. 2, Aug. 2020, pp. 294-03, doi:10.15311/selcukdentj.695767.

Vancouver

1.Özgün Günay, Özge Doğanay, Olgu Enis Tok, Alper Alkan. Radyoterapiyi takiben kritik boyutta oluşturulan kemik defektlerinde antibiyotiklerin etkinliğinin deneysel olarak incelenmesi. Selcuk Dent J. 2020 Aug. 1;7(2):294-303. doi:10.15311/selcukdentj.695767