KRİYOCERRAHİ İLE TEDAVİ EDİLEN FOKAL EPİTELYAL HİPERPLAZİ: BİR OLGU SUNUMU

Abstract

Fokal epitelyal hiperplazi (FEH) human papilloma virus (HPV) 13 veya 32 genotipleri tarafından üretilen, genetik geçiş izlenebilen oral mukozanın nadir, benign bir hastalığıdır. Bu vaka sunumunda 16 yaşındaki kadın hastanın oral mukozasında gözlenen lezyonların klinik, histopatolojik özellikleri ve tedavisi sunuldu. FEH’de çoğu kez tedavi gereksinimi olmasa da estetik ve sürekli ısırma şikayetleri sonucu çeşitli tedaviler tercih edilebilir. 0.2 ile 1.5 cm arasında değişen çoklu lezyonlar izlenen bu vakada pek çok avantajları nedeniyle kriyocerrahi tedavisi tercih edildi ve lezyonlarda belirgin bir iyileşme gözlendi.

Keywords

• Fokal epitelyal hiperplazi
• Heck hastalığı
• kriyocerrahi
• human papilloma virüs

FOCAL EPITHELIAL HYPERPLASIA TREATED WITH CRYOSURGERY: A CASE REPORT

Abstract

Focal epithelial hyperplasia (FEH) is a rare, benign disease of the oral mucosa, which is caused by human papillomavirus (HPV) genotypes 13 and 32 with probable genetic susceptibility. In this case report, we present the clinical, histopathological features and treatment of lesions observed in the oral mucosa of a 16-year-old female patient. Although FEH does not require any treatment in most cases, various treatments are available for patients with aesthetic concerns or complaints of functional impairment due to constant biting on the lesions. Cryosurgery was preferred for this patient with multiple lesions varying in size from 0.2 to 1.5 cm because of its many advantages, and considerable improvement was observed in the lesions.

Keywords

• Cryosurgery
• focal epithelial hyperplasia
• Heck's disease
• human papillomavirus

References

1. Ozden B, Gunduz K, Gunhan O, Ozden FO. A case report of focal epithelial hyperplasia (Heck’s disease) with PCR detection of human papillomavirus. Journal of maxillofacial and oral surgery. 2011;10(4):357-60.
2. Bascones-Martínez A, Cok S, Bascones-Ilundáin C, Arias-Herrera S, Gomez-Font R, Bascones-Ilundáin J. Multifocal epithelial hyperplasia: A potentially precancerous disease? Oncology letters. 2012;3(2):255-8.
3. Said AK, Leao JC, Fedele S, Porter SR. Focal epithelial hyperplasia–an update. Journal of oral pathology & medicine. 2013;42(6):435-42.
4. Terezhalmy G, Riley C, Moore W. Focal epithelial hyperplasia (Heck's disease). Quintessence international (Berlin, Germany: 1985). 2001;32(8):664-5.
5. Falaki F, Amir Chaghmaghi M, Pakfetrat A, Delavarian Z, Mozaffari P, Pazooki N. Detection of human papilloma virus DNA in seven cases of focal epithelial hyperplasia in Iran. Journal of oral pathology & medicine. 2009;38(10):773-6.
6. Cuberos V, Perez J, Lopez CJ, Castro F, Gonzalez LV, Correa LA, et al. Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: a case-control study. Journal of clinical virology. 2006;37(1):21-6.
7. KAPDAN A, AKSOY S, ÖZTÜRK C. FOKAL EPİTELYAL HİPERPLAZİ (HECK HASTALIĞI): OLGU RAPORU.
8. Jayasooriya P, Abeyratne S, Ranasinghe A, Tilakaratne W. Focal epithelial hyperplasia (Heck's disease): report of two cases with PCR detection of human papillomavirus DNA. Oral diseases. 2004;10(4):240-3.

9. Kutluay H, Çankal DA, Bozkaya S. Kriyocerrahi ve ağız cerrahisinde kullanım alanları. Gazi Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2010;27(1):53-63.
10. Ghalayani P, Tavakoli P, Eftekhari M, Haghighi MA. Oral focal epithelial hyperplasia: Report of three cases/oral fokal epitel hiperplazisi: Üç Olgu Sunumu. Turkish Journal of Pathology. 2015;31(1):60-3.
11. Kumaraswamy K, Vidhya M. Human papilloma virus and oral infections: an update. Journal of cancer research and therapeutics. 2011;7(2):120.
12. Mosannen-Mozaffari P, Falaki F, Amirchaghmaghi M, Pakfetrat A, Dalirsani Z, Saghafi Khadem S. Multifocal epithelial hyperplasia, a rare oral infection in Asia: Report of twelve cases in Iran. 2010.
13. Marvan E, Firth N. Focal epithelial hyperplasia in an HIV positive man. An illustrated case and review of the literature. Australian dental journal. 1998;43(5):305-10.
14. Mansouri Z, Bakhtiari S, Noormohamadi R. Extensive focal epithelial hyperplasia: a case report. Iranian journal of pathology. 2015;10(4):300.
15. Korkmaz S, Kaçar N, TAŞLI L, ŞANLI B, Demirkan N. Erişkin bir Heck hastalığı olgusu. Pamukkale Tıp Dergisi. 2011(3):158-62.
16. Borborema-Santos CM, Castro MMd, Santos PJBd, Talhari S, Astolfi-Filho S. Oral focal epithelial hyperplasia: report of five cases. Brazilian dental journal. 2006;17(1):79-82.
17. Türkoğlu K, Tuncer N, ÇELEBİOĞLU B. İnflamatuar papiller hiperplazi olgusunun kriyocerrahi yöntemi ile tedavisi: olgu raporu. Cumhuriyet Dental Journal. 2009;12(2):135-8.
18. Gürbüz D, Güngörmüş, Y , Gürsan, Y . İYİ HUYLU ORAL LEZYONLARIN TEDAVİSİNDE KRİYOCERRAHİ. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 2001;2001(3).