Ameloblastic Fibroma: A Case Report

Yıl 2024, Cilt: 11 Sayı: 2, 227 - 230, 19.08.2024

Ahmet Aktı , Ziya Ozan Cengiz , Omer Erdur , Gökhan Gürses

https://doi.org/10.15311/selcukdentj.1403551

Öz

Ameloblastic fibroma (AF) is a rare benign odontogenic tumor that usually occurs in the first two decades of life. It can occur in the mandible or maxilla but is most commonly found in the posterior region of the mandible.

A 6-year-old female patient applied to our clinic due to swelling in her mouth. The patient had no medical history of previous trauma or pain in the affected area. Enucleation of the tumor was performed under general anesthesia. Following enucleation, surrounding bone curettage was performed and adjacent teeth were removed. As a result of morphological and immunohistochemical examinations, the patient was diagnosed with ameloblastic fibroma.

Although AF is a rare tumor, it is more common in children. Patients with AF need to be followed for a long time due to the ability of AF to turn into ameloblastic fibrosarcoma, which is its malignant form. The patient is followed frequently and has been asymptomatic for 1 year.

Anahtar Kelimeler

Ameloblastic Fibroma, Benign tumors, Enucleation

Ameloblastik Fibroma: Olgu Sunumu

Öz

Ameloblastik fibroma (AF), genellikle yaşamın ilk yirmi yılında ortaya çıkan nadir görülen benign odontojenik bir tümördür. Mandibula veya maksillada oluşabilir ancak en sık mandibulanın arka bölgesinde bulunur.

6 yaşında kadın hasta ağzındaki şişlik nedeniyle kliniğimize başvurdu. Hastanın tıbbi geçmişi, etkilenen bölgeye daha önce travma veya ağrı öyküsü yoktu. Tümörün enükleasyonu genel anestezi altında gerçekleştirildi Enükleasyonun ardından çevredeki kemik küretajı yapıldı ve komşu dişler çıkarıldı. Morfolojik ve immünhistokimyasal incelemeler sonucunda hastaya ameloblastik fibroma tanısı konuldu.

AF nadir görülen bir tümör olmasına rağmen çocuklarda daha sık görülür. AF'nin, malign formu olan ameloblastik fibrosarkoma dönüşme yeteneği nedeniyle AF'li hastaların uzun süre takip edilmesi gerekmektedir. Hasta sık sık takip edilmekte olup 1 yıldır asemptomatiktir.

Anahtar Kelimeler

Ameloblastik Fibroma, Benign tümör, Enükleasyon

Kaynakça

• 1. Soluk-Tekkesin, Merva, and John M. Wright. “The World Health Organization Classification of Odontogenic Lesions: A Summary of the Changes of the 2022 (5th) Edition.” Turk Patoloji Dergisi, vol. 38, no. 2, 2022, pp. 168–84.
• 2. WHO Classification of Tumours Editorial Board. Head and neck tumours [Internet; beta version ahead of print]. Lyon (France): International Agency for Research on Cancer; 2022. (WHO classification of tumours series, 5th ed.; vol. 9). Available from: https://tumourclassification.iarc.who.int/chapters/52.
• 3. Tozoglu S, Hatipoglu M, Aytekin Z, Gurer EI. Extensive ameloblastic fibroma of the mandibula in a female adult patient: A case report with a follow-up of 3 years. Eur J Dent. 2016;10: 139–143.
• 4. De Campos WG, Esteves CV, Paiva GA, Zambon CE, Rocha AC, Lemos CA. Successful Management of a Gigantic Ameloblastic Fibroma: A 12-Year Follow-up. Ann Maxillofac Surg. 2019;9: 197–200.
• 5. Muller S, Parker DC, Kapadia SB, Budnick SD, Barnes EL. Ameloblastic fibrosarcoma of the jaws. A clinicopathologic and DNA analysis of five cases and review of the literature with discussion of its relationship to ameloblastic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79: 469–477.
• 6. Reichart P, Philipsen HP. Odontogenic Tumors and Allied Lesions. Quintessence Publishing Company; 2004.
• 7. Jk DR, Sharma A, Sharma S, Arya V, Das R. An Aggressive Ameloblastic Fibroma in Maxilla of a 5-Year-Old Child—Reconstruction of the Defect with Buccal Flap Advancement—A Conservative Approach. International Journal of Clinical Medicine. 2015. pp. 579–585. doi:10.4236/ijcm.2015.68077
• 8. Buchner, Amos, and Marilena Vered. “Ameloblastic Fibroma: A Stage in the Development of a Hamartomatous Odontoma or a True Neoplasm? Critical Analysis of 162 Previously Reported Cases plus 10 New Cases.” Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 116, no. 2013, pp. 598–606.
• 9. Cahn LR, Blum T. Ameloblastic odontoma: case report critically analyzed. J Oral Surg. 1952;10:169-170
• 10. Philipsen HP, Reichart PA, Praetorius F. Mixed odontogenic tumours and odontomas: considerations on interrelationship. Review of the literature and presentation of 134 new cases of odontomas. Oral Oncol. 1997;33:86-99
• 11. Gardner DG. The mixed odontogenic tumors. Oral Surg Oral Med Oral Pathol. 1984;58:166-168.
• 12. Atarbashi-Moghadam, Saede, et al. “Unusual Microscopic Changes of Ameloblastic Fibroma and Ameloblastic Fibro-Odontoma: A Systematic Review.” Journal of Clinical and Experimental Dentistry, vol. 11, no. 5, May 2019, pp. e476–81.
• 13. Hansen LS, Ficarra G. Mixed odontogenic tumors: an analysis of 23 new cases. Head Neck Surg. 1988;10:330-343.
• 14. Gardner DG, Smith FA,Weinberg S. Ameloblasticfibroma. A benign tumour treatable by curettage. J Can Dent Assoc. 1969;35:306-310.
• 15. Cawson RA, Binnie WH, Barett AW, Wright JM, eds. Oral Disease: Clinical and Pathological Correlations. 3rd ed. Edinburgh, Scotland: Mosby; 2001:6.15-6.16.
• 16. Marx RE, Stern D, eds. Oral and Maxillofacial Pathology: a Rationale for Diagnosis and Treatment. 2nd ed. Chicago, IL: Quinessence Publishing Co; 2012:710-712.
• 17. Sapp JP, Eversole LR, Wysocki GP, eds. Contemporary Oral and Maxillofacial Pathology. St Louis, MO: Mosby; 2004:155-156.
• 18. Nelson BL, Folk GS. Ameloblastic fibroma. Head Neck Pathol. 2009;3: 51–53.
• 19. Gold L, Williams TP. Odontogenic tumors: surgical pathology and management. In: Fonseca RJ, Marciani RD, Turvey TA, eds. Oral and Maxillofacial Surgery. Vol 2. 2nd ed. St Louis, MO: Saunders; 2009:527-528.
• 20. Neville BW, Damm DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. 3rd ed. St Louis, MO: Saunders; 2009:719-720
• 21. Philipsen H, Reichart P, Prtorius F. Mixed odontogenic tumours and odontomas. Considerations on interrelationship. Review of the literature and presentation of 134 new cases of odontomas. Oral Oncology. 1997. pp. 86–99. doi:10.1016/s0964-1955(96)00067-x
• 22. Ide F, Kitada M, Tanaka A, Sakashita H, Kusama K. Ameloblastic Fibroma: A critical evaluation of reported cases provides evidence of two types. Oral Medicine & Pathology. 2002. pp. 55–59. doi:10.3353/omp.7.55
• 23. Buchner A, Vered M. Ameloblastic fibroma: a stage in the development of a hamartomatous odontoma or a true neoplasm? Critical analysis of 162 previously reported cases plus 10 new cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116: 598–606.
• 24. Costa DOP da, Alves ATNN, CalasansMaia MD, Cruz RL da, Lourenço SQC. Maxillary ameloblastic fibroma: A case report. Braz Dent J. 2011;22:171-174
• 25. Medina JE. Surgical pathology of the head and neck, By Leon Barnes, MD, 1866 pp, illus. Marcel Dekker, Inc., New York, 1985, Volumes 1 and 2. $250. Head & Neck Surgery. 1986. pp. 67–67. doi:10.1002/hed.2890090113