Hafif Şiddette COVID-19'un Sol Ventrikül Fonksiyonları Üzerindeki Uzun Dönem Etkileri

Abstract

Amaç: COVID-19 hastalığının, sol ventrikül fonksiyonu üzerindeki uzun dönem etkilerini speckle tracking ekokardiyografi kullanarak, değerlendirmeyi amaçladık. Yöntemler: Çalışmamıza 15 Ağustos 2020 - 01 Eylül 2020 tarihleri arasında merkezimizde COVID-19 hastalığı tanısı konan ve hastaneye yatmayan 96 hasta ile yaş ve cinsiyet olarak uyumlu, 96 kontrol olgusu dahil edildi. Bulgular: Ortalama takip süresi 137 ± 7 gündü. Beyaz kan hücresi, nötrofil ve lenfosit, COVID-19 grubunda önemli ölçüde daha düşüktü ve C-reaktif protein (CRP) ve nötrofil lenfosit oranı (NLR) önemli ölçüde daha yüksekti. (sırasıyla 6,6 ± 2,8 - 24,4 ± 21,8, p <0,001 ve 4,1 ± 2,5 - 7,1 ± 4, p <0,001). Global longutinal strain (LV-GLS) ve global circumferential strain (LV-GCS), COVID-19 grubunda önemli ölçüde daha düşüktü. (-20,1 ± 3,1 vs -15,9 ± 2, p <0,001 ve -29,3 ± 2,1 vs -26.3 ± 2,1, p <0,001). LV-GLS ve LV-GCS'nin CRP (sırasıyla rs = -0.515, p <0.001 ve rs = 0.-466, p <0.001) ve NLR (rs = -0.494, p <0.001 ve rs = -434, p <0,001, sırasıyla). Sonuç: COVID-19 hastalığının hem LV-GCS hem de LV-GLS üzerindeki olumsuz etkileri uzun süre devam etmektedir. Bu olumsuz etkiler, aktif enfeksiyon sırasında ölçülen CRP seviyeleri ve NLR ile ilişkili görünmektedir.

Keywords

• Covid 19,
• Sol ventrikül disfonksiyonu
• Ekokardiyografi

Long Term Effects of Mild Severity COVID-19 on Left Ventricular Functions

Abstract

Objective: We aimed to evaluate long term effects of COVID-19 disease on left ventricular function using speckle tracking echocardiography. Methods: In our study, 96 non-hospitalized patients who were diagnosed with COVID-19 disease in our center between 15 August 2020 and 01 September 2020 and 96 age and gender matched control subjects were included. Results:The mean follow up duration was 137 ± 7 days. White blood cell, neutrophile and lymphocyte were significantly lower and C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) were significantly higher in the COVID-19 group. (6.6 ± 2.8 vs. 24.4 ± 21.8, p <0.001 and 4.1 ± 2.5 vs. 7.1 ± 4, p <0.001, respectively). Global longutinal strain (LV-GLS) and global circumferential strain (LV-GCS) were significantly lower in the COVID-19 group. (-20.1 ± 3.1 vs -15.9 ± 2, p <0.001 and -29.3 ± 2.1 vs -26.3 ± 2.1, p <0.001, respectively). LV-GLS and LV-GCS were found to be negatively correlated with CRP (rs = -0.515, p <0.001 and rs = 0.-466, p <0.001, respectively) and NLR (rs = -0.494, p <0.001 and rs = -434, p <0.001, respectively). Conclusion: Deteriorating effects of COVID-19 disease on both LV-GCS and LV-GLS can be seen even in the long term. These detrimental effects seem to be associated with CRP levels and NLR measured in the course of active infection.

Keywords

• Covid 19
• Left ventricular dysfunction
• echocardiography

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