The diagnostic value of Neutrophil Lymphocyte ratio in acute appendicitis

Yıl 2014, , 78 - 81, 01.06.2014

Yusuf Sevim Ozan Baris Namdaroglu Muhammet Yener Akpınar Ahmet Goktug Ertem

https://doi.org/10.5505/sakaryamj.2014.29863

Cited By: 1

Öz

Objective: The aim of our study is to evaluate, and discuss the diagnostic value of neutrophil lymphocyte ratio (NLR) in acute appendicitis.Materials and Methods: Three hundred and ten patients underwent appendectomy included in our study. Patients ages, genders, preoperative white blood cell (WBC), neutrophil and lymphocyte percentages, and NLR, applied ultrasonography (US) findings, and pathological reports were retrieved retrospectively. Student t test, chi-square test, and odds ratios were used in statistical analysis. Results: Our study included appendectomy applied 310 patients, 176 patients (56,8%) were male, and male-female ratio of patients was determined as 1,3: 1. The mean age of patients was 24,5 ± 12,2 years. Pathological reports showed that 54 patients reported as appendix vermiformis with no sign of inflammation, and also 14 patients (5,5%) reported as perforated, 5 patients (2,0%) as acute gangrenous appendicitis, 1 patient as musinous cystadenoma, and 1 patie.nt as carsinoid tumor.Average value of NLR was 7,0±5,6 in patients with acute appendicitis. Elevated NLR values were found statistically associated with acute appendisitis diagnosed pathologically (p

Anahtar Kelimeler

Acute appendicitis, Neutrophil Lymphocyte Ratio

Akut Apandisitte Nötrofil Lenfosit Oranının Tanısal Değeri

Öz

Amaç: Çalışmamızın amacı akut apandisitte nötrofil lenfosit oranının (NLR) tanısal dağerini değerlendirmektir.Gereç ve Yöntemler: Apendektomi uygulanan 310 hasta çalışmamıza dahil edildi.Hastaların yaşları, cinsiyetleri, preoperatif beyaz küre, nötrofil yüzdesi, lenfosit yüzdesi ve NLR'leri, çekilmiş olan ultrasonografi (USG) ve patoloji sonuçları retrospektif olarak elde edildi. İstatistik analizde student t test, ki-kare testi ve olasılık oranları kullanıldı.Bulgular: Çalışmamıza appendektomi ameliyatı yapılan 310 hasta dahil edildi. Çalışmaya dahil olan hastaların 176'sı (%56,8) erkek idi ve erkek kadın oranı 1,3: 1 olarak tespit edildi. Hastaların ortalama yaşı 24,5±12,2 yıl olarak bulundu. Patoloji sonuçları incelendiğinde 54 hastanın inflamasyon bulgusu olmayan appendiks vermiformis, 14 hastanın (%5,5) perfore, 5 hastanın(%2,0) gangranöz akut appendisit, 1'er hastanın karsinoid ve müsinöz kistadenom olarak rapor edildiğini görüldü. Akut appendisit çıkan hastalarda NLR ortalama değeri 7,0±5,6 idi. NLR'nin yüksek olması patolojik olarak akut appendisit arasında istatistiksel anlamlı ilişki olduğu görüldü (p

Anahtar Kelimeler

Akut apandisit, Nötrofil Lenfosit Oranı

Kaynakça

• Alvarado A. A practical score for the early diagnosis of acute appendicitis. Ann Emerg Med 1986;15(5):557-64.
• Yildirim O, Solak C, Koçer B, Unal B, Karabeyoglu M, Bozkurt B, et al. The role of serum inflammatory markers in acute appendicitis and their success in preventing negative laparotomy. J Invest Surg 2006;19(6):345-52.
• Goodman DA, Goodman CB, Monk JS. Use of the neutrophil:lymphocyte ratio in the diagnosis of appendicitis. Am Surg 1995;61(3):257-9.
• BiaŞas M, Taran K, Gryszkiewicz M, Modzelewski B. Evaluation of neutrophil-lymphocyte ratio usefulness in the diagnosis of appendicitis. Wiad Lek 2006;59(9-10):601-6.
• Yazici M, Ozkisacik S, Oztan MO, Gürsoy H. Neutrophil/lymphocyte ratio in the diagnosis of childhood appendicitis. Turk J Pediatr 2010;52(4):400-3.
• Markar SR, Karthikesalingam A, Falzon A, Kan Y. The diagnostic value of neutrophil: lymphocyte ratio in adults with suspected acute appendicitis. Acta Chir Belg 2010;110(5):543-7.
• Ohmann C, Franke C, Kraemer M,Yang Q. Status report on epidemiology of acute appendicitis. Chirurg 2002;73(8):769-76.
• Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 1990;132(5):910-25.
• Khan MN, Davie E, Irshad K. The role of white cell count and C-reactive protein in the diagnosis of acute appendicitis. J Ayub Med Coll Abbottabad 2004;16(3):17-9.
• Anderson RE, Hugander AP, Ghazi SH, Ravn H, Offenbartl SK, Nyström PO, Olaison GP. Diagnostic value of disease history, clinical presentation, and inflammatory parameters of apendicitis. World J Surg 1999;23(2):133-40.
• de Jager CP, van Wijk PT, Mathoera RB, de Jongh-Leuvenink J, van der Poll T, Wever PC. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care 2010;14(5):R192.
• Kamran H, Naveed D, Nazir A, Hameed M, Ahmed M, Khan U. Role of total leukocyte count in diagnosis of acute appendicitis. J Ayub Med Coll Abbottabad 2008;20(3):70-1.
• Narci A, Tuncer AA, Cetinkursun S. Diagnostic importance of neutrophil/ lymphocyte ratio in childhood appendicitis. Med J Kocatepe 2009;10:5-7.
• Terradas R, Grau S, Blanch J, Riu M, Saballs P, Castells X, et al. Eosinophil count and neutrophil-lymphocyte count ratio as prognostic markers in patients with bacteremia: a retrospective cohort study. PLoS One 2012;7(8):e42860.
• Cook EJ, Walsh SR, Farooq N, Alberts JC, Justin TA, Keeling NJ. Post- operative neutrophil-lymphocyte ratio predicts complications following colorectal surgery. Int J Surg 2007;5(1):27-30.
• Chua W, Charles KA, Baracos VE, Clarke SJ. Neutrophil/lymphocyte ratio predicts chemotherapy outcomes in patients with advanced colorectal cancer. Br J Cancer 2011;104(8):1288-95.
• Azab B, Bhatt VR, Phookan J, Murukutla S, Kohn N, Terjanian T, et al. Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients. Ann Surg Oncol 2012;19(1):217-24.