Fertility relevant hormones in men with spinal cord injury: case control study

Yıl 2012, , 71 - 76, 01.06.2012

Cevdet Serkan Gökkaya Özer Güzel N. Kutay Ordu Gökkaya Özgür Demirdal Süleyman Bulut Cüneyt Özden Halil Uçan Ali Memiş

https://doi.org/10.5505/sakaryamj.2012.75047

Öz

Objective: Individual and social effects of spinal cord injury is an important cause of morbidity. After the spinal cord injury substantial hormonal changes are seen. The aim of the study was to evaluate the fertility-related hormonal profiles and the clinic implications in men with traumatic spinal cord injury. Materials and Methods: Total of 59 patients with spinal cord injury (complete (Group 1, n = 41) and incomplete (Group 2, n = 18)) and 54 healthy volunteers (Group 3) participated in this study. Blood samples were collected for determination of FSH, LH, Prolactin, tTestosteron, sTestosteron, DHEA-S, estradiol levels of all patients and volunteers included in the study. In addition, all patients and volunteers completed IIEF (International Index of Erectile Function) questionnaire. Patients (Group 1 and Group 2) and healthy volunteers (Group 3) were compared with each other.Results: PRL levels of both SCI groups (Group 1 and Group 2), were significantly higher (p

Anahtar Kelimeler

Spinal cord injury, hormones, sexual dysfunction

Spinal kord yaralanmalı erkeklerde fertilite ilişkili hormonlar: vaka-kontrol çalışması

Öz

Amaç: Omurilik yaralanmaları bireysel ve toplumsal etkileri olan önemli bir morbidite nedenidir. Yaralanma sonrası önemli hormonal değişiklikler görülür. Çalışmamızda omurilik yaralanmalı erkek hastalarda fertilite ilişkili hormonal parametreleri ve klinik yansımalarını değerlendirdik.Gereç ve Yöntemler: Çalışmamıza komplet (Grup 1 n=41) ve inkomplet (Grup 2 n=18) spinal yaralanması olan toplam 59 hasta ile 54 sağlıklı gönüllü (Grup 3) dahil edildi. Çalışmaya dahil edilen tüm hasta ve gönüllülerden FSH, LH, Prolaktin, tTestosteron, sTestosteron, DHEA-S, Östradiol seviyelerinin tespiti için kan numuneleri alındı. Ayrıca tüm hasta ve gönüllülere İİEF (Uluslararası Ereksiyon İşlevi Değerlendirme) formu uygulandı. Hastalar (Grup 1 ve Grup 2) ile sağlıklı gönüllüler (Grup 3) ve her grup birbiri ile karşılaştırıldı.Bulgular: Hastaların tamamında (Grup 1 ve Grup 2) PRL düzeyleri kontrol grubundan (Grup 3) daha yüksekti (p

Anahtar Kelimeler

Omurilik yaralanması, hormonlar, seksüel disfonksiyon

Kaynakça

• White MJ, Rintala DH, Hart KA, Fuhrer MJ. Sexual activities, concerns and interests of women with spinal cord injury living in the community. Am J Phys Med Rehabil 1993;72:372-8.
• Comfort A, Money TO, Cole TM, Chilgren RA. Sexual options for paraplegics and tetraplegics. Little Brown Company, Boston USA 1975
• Naftchi NE, Viau AT, Sell GH, Lowman EW. Pituitary-testicular axis dysfunction in spinal cord injury. Arch Phys Med Rehabil 1980;61:402-5.
• Safarinejad MR. Level of injury and hormone profiles in spinal cord-injured men. Urology 2001;58:671-6.
• Naderi AR, Safarinejad MR. Endocrine profiles and semen quality in spinal cord injured men. Clin Endocrinol (Oxf) 2003;58:177-84.
• Huang TS, Wang YH, Lee SH, Lai JS. Impaired hypothalamus- pituitary-adrenal axis in men with spinal cord injuries. Am J Phys Med Rehabil 1998;77:108-12.
• Rojas Vega S, Abel T, Lindschulten R, Hollmann W, Bloch W, Strüder HK. Impact of exercise on neuroplasticity-related proteins in spinal cord injured humans. Neuroscience 2008;153:1064-70.
• Clark MJ, Schopp LH, Mazurek MO, Zaniletti I, Lammy AB, Martin TA, Thomas FP, Acuff ME. Testosterone levels among men with spinal cord injury: relationship between time since injury and laboratory values Am J Phys Med Rehabil 2008;87:758-67.
• Schopp LH, Clark M, Mazurek MO, Hagglund KJ, Acuff ME, Sherman AK, Childers MK. Testosterone levels among men with spinal cord injury admitted to inpatient rehabilitation. Am J Phys Med Rehabil 2006;85:678-84.
• Kostovski E, Iversen PO, Birkeland K, Torjesen PA, Hjeltnes N. Decreased levels of testosterone and gonadotrophins in men with long-standing tetraplegia Spinal Cord 2008;46:559-64.
• Durga A, Sepahpanah F, Regozzi M, Hastings J, Crane DA. Prevalence of testosterone deficiency after spinal cord injury. PM R 2011;3:929-32.
• Perkash I, Martin DE, Warner H, Blank MS, Collins DC. Reproductive biology of paraplegics: results of semen collection, testicular biopsy and serum hormone evaluation. J Urol 1985;134:284-8.
• Celik B, Sahin A, Caglar N, Erhan B, Gunduz B, Gultekin O, Karabulut M. Sex hormone levels and functional outcomes: a controlled study of patients with spinal cord injury compared with healthy subjects. Am J Phys Med Rehabil 2007;86:784-90.
• Herbst KL, Bhasin S. Testosterone action on skeletal muscle. Curr Opin Clin Nutr Metab Care 2004;7:271-7.
• Biatek M, Zaremba P, Borowicz KK, Czuczwar SJ. Neuroprotective role of testosterone in the nervous system. Pol J Pharmacol 2004;56:509-18.
• Tanzer L, Jones KJ. Neurotherapeutic action of testosterone on hamster facial nerve regeneration: temporal window of effects. Horm Behav 2004;45:339-44.
• Giuliano F, Sanchez-Ramos A, Löchner-Ernst D, Del Popolo G, Cruz N, Leriche A, Lombardi G, Reichert S, Dahl P, Elion- Mboussa A, Casariego J. Efficacy and safety of tadalafil in men with erectile dysfunction following spinal cord injury. Arch Neurol 2007;64:1584-92.
• Alexander MS, Brackett NL, Bodner D, Elliott S, Jackson A, Sonksen J; National Institute on Disability and Rehabilitation Research. Measurement of sexual functioning after spinal cord injury: preferred instruments. J Spinal Cord Med. 2009;32:226- 36.
• Lombardi G, Macchiarella A, Cecconi F, Del Popolo G. Ten-year follow-up of sildenafil use in spinal cord-injured patients with erectile dysfunction. J Sex Med 2009;6:3449-57