Akut İskemik İnme ile Hematolojik Parametreler ve Lipid Profilinin İlişkisi

Abstract

Bu çalışmanın amacı akut iskemik inmeli (Aİİ) hastalarda rutin laboratuvar parametrelerinin klinik sonuçlar üzerine etkisini araştırmaktır. Çalışmamız, retrospektif ve kesitsel olarak tasarlanmıştır. Çalışmaya akut iskemik inme tanısı ile kliniğimizde yatarak tedavi gören 94 Aİİ’li hasta çalışmaya dahil edildi. Başvuru sırasındaki laboratuvar verileri, demografik ve klinik özellikler kaydedildi. Hastaların tedaviden 3 ay sonraki nörolojik özürlülükleri modifiye Rankin Skalası (mRS) ile değerlendiridi. Hastalar mRS’na göre hastalar iki gruba ayrıldı. mRS 0-2 arası iyi prognoz ve mRS 3-6 arası kötü prognoz olarak kabul edildi. Çalışmaya alınan 94 hastanın 47’si erkek, 47’si kadındı. Yaş ortalamaları 71,18± 11,92 yıl idi. Hipertansiyon, kalp yetmezliği ve atrial fibrilasyon görülme oranının kötü prognozlu grupta daha yüksek olduğu belirlendi (sırasıyla; %84,2 & %46.4; p<0,001, %21,1 & %5.4; p=0,04, %50 & %26,8; p=0,03). Laboratuvar parametrelerinden hemoglobin, eozinofil, total-kolesterol, ldl-kolesterol ve trigliserit değerleri mRS ≥3 olan grupta anlamlı olarak düşük idi. ROC analizi sonucu hemoglobin, eozinofil, total-kolesterol, ldl-kolesterol ve trigliseridin eğri altındaki alanı anlamlı olarak fazlaydı [(AUC: 0,710 %95 GA: 0,60-0,81); Duyarlılık = %67,6, Özgüllük = %67,9, p=0,001]. Çok değişkenli lojistik regresyon modelinde yalnızca NIHSS skoru (National Institues Of Health Stroke Scale Scores) bağımsız olarak sakatlık derecesi ile ilişkilendirildi (p=0,001). İnme sonucunu öngörmede NIHSS bağımsız bir faktördür. Bu çalışmada rutin laboratuvar parametrelerinden hemoglobin düzeyi, eozinofil seviyesi, LDL ve total kolestrol düzeyleri ile infarkt hacmi arasında hemoglobin ve LDL-kolesterolün NIHSS skorları ile ters yönlü anlamlı bir ilişki olduğu belirlendi.

Keywords

• Akut iskemik inme
• laboratuvar
• infarkt hacmi
• klinik sonuç

Supporting Institution

Destekleyici yoktur.

Ethical Statement

Etik kurul onayı alınmıştır.

Thanks

Çalışmaya katılan tüm hastalarımıza teşekkür ederiz.

The Relationship of Hematologic Parameters and Lipid Profile with Acute Ischemic Stroke

Abstract

Objective: This study aims to investigate the effect of routine laboratory parameters on clinical outcomes in patients with acute ischemic stroke (AIS). Materials and Methods: Our study was designed as retrospective and cross-sectional. 94 patients with AIS who received inpatient treatment in our clinic with a diagnosis of acute ischemic stroke were included in the study. Laboratory data, demographic, and clinical characteristics were recorded at the time of admission. Neurological disabilities of the patients 3 months after treatment were evaluated with the modified Rankin Scale (mRS). mRS 0-2 was considered a good prognosis and mRS 3-6 was considered a poor prognosis. Results: Of the 94 patients included in the study, 47 were men and 47 were women. The mean age was 71.18±11.92 years. Laboratory parameters hemoglobin, eosinophil, totalcholesterol, ldl-cholesterol, and triglyceride values were significantly lower in the group with mRS≥3. As a result of ROC analysis, the area under the curve of hemoglobin, eosinophil, total-cholesterol, ldl-cholesterol, and triglyceride was significantly higher[(AUC: 0.710 95%CI: 0.60-0.81); Sensitivity=67.6%, Specificity=67.9%, p=0.001]. In the multivariable logistic regression model, only the NIHSS score (National Institutes Of Health Stroke Scale Scores) was independently associated with the degree of disability (p=0.001). NIHSS is an independent factor in predicting stroke outcomes. Conclusion: It was determined that there was a significant inverse relationship between the routine laboratory parameters hemoglobin level, eosinophil level, LDL and total cholesterol levels, and infarct volume with the NIHSS scores of hemoglobin and LDLcholesterol.

Keywords

• Acute ischemic stroke
• Laboratory
• Infarct volume
• Clinical outcome

Supporting Institution

No financial support was used for the study included in this article.

Ethical Statement

Ethical approval was obtained.

Thanks

We would like to thank our patients who participated in the study.

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