Evaluation of Cardiorenal Metabolic Syndrome in Patients with Heart Failure with Preserved Ejection Fraction. How Aware Are We?

Year 2025, Volume: 15 Issue: 3, 192 - 199, 30.09.2025

Hüseyin Ali Öztürk , Erdinc Gulumsek , Dilan Damla Ozturk , Fatih Necip Arıcı , Cigdem Erhan , Bektaş Işık , Mehmet Can Erişen , Berçem Berent Kaya , Ugur Can Izlimek , Cahit Dincer , Ahmet Gazi Mustan , Çisem Yılmaz , Tayyibe Saler , Hilmi Erdem Sümbül

https://doi.org/10.31832/smj.1684457

https://izlik.org/JA43GX36MU

Abstract

Aim: Despite the prevalence of cardiorenal metabolic diseases (CRMD) in heart failure with preserved ejection fraction (HFpEF) patients and their significant complications, they are thought to be under-recognized and under-screened. In our study, we aimed to evaluate patients with HFpEF who were followed up in our internal medicine clinic.
Methods: Our retrospective and cross-sectional study included 348 patients with HFpEF. Patients were evaluated according to laboratory, demographic, clinical, electrocardiographic and ultrasonographic findings.
Results: Of the patients, 37.95% had diabetes mellitus, 23.3% had chronic kidney disease, 70.1% had hypertension and 59.2% had metabolic dysfunction-associated steatotic liver disease. The mean NT-proBNP level was 360.7 ± 13.7.
Conclusion: We recommend that HFpEF, which is associated with increased cardiovascular mortality and morbidity in patients with CRMD, should be screened clinically and with NT-proBNP and evaluated with transthoracic echocardiography if necessary.

Keywords

CRMD , Diabetes mellitus , HFpEF , Hypertension , MASLD

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