Periferik Sinir Rejenerasyonu ve Kök Hücre Tedavileri

Abstract

Bu derlemede yazarlar kök hücre/progenitör hücre transplantasyonunun sinir hasarlarının iyileştirilmesinde kullanımı ile ilgili yakın zamandaki gelişmeler ve bu alandaki başlıca çalışmalar hakkında bilgi vermeyi amaçlamaktadır. Periferik sinirlerin akson rejenerasyonu ve hedef dokularını tekrar innerve etme potansiyeline sahip olmalarına rağmen ağır sinir hasarı durumlarında düzelme sınırlı kalmaktadır. Denervasyona uğramış periferik sinirin Schwann hücrelerinin rejenerasyonda yeteri kadar rol alamayışlarından dolayı denerve olmuş distal sinir dokusu ortamının dış kaynaklı doku hücreleriyle desteklenmesi yaklaşımı gerçekçi görülmüştür. Çeşitli kök hücrelerinin periferik sinir rejenerasyonundaki etkileri çalışılmıştır. Deri, kemik iliği ve yağ doku kökenli kök hücreleri Schwann hücrelerine dönüşme kapasiteleriyle en ümit verici adaylar olarak belirlenmiştir. Pluripotent indüklenmiş kök hücre denemelerine ek olarak, yakın zamanlarda yapılan çalışmalar kök hücrelerinde büyüme faktörlerinin ifadesinin uyarılması da rejenerasyonda önemli potansiyele sahiptir. Kök hücrelerinin etkili kullanılabilecek kaynak olmaları ve sinir rejenerasyonunda ümit verici faktörler olduklarının düşünülmesine rağmen bu hücre tedavi potansiyellerinin klinikte kullanılması için gerekli ideal yöntemler henüz oluşturulamamıştır.

Keywords

• Kök hücre
• periferik sinir
• rejenerasyon

References

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